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Gene: NIPSNAP3A |
Gene summary for NIPSNAP3A |
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Gene information | Species | Human | Gene symbol | NIPSNAP3A | Gene ID | 25934 |
Gene name | nipsnap homolog 3A | |
Gene Alias | HSPC299 | |
Cytomap | 9q31.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9UFN0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25934 | NIPSNAP3A | HTA11_347_2000001011 | Human | Colorectum | AD | 2.30e-10 | 4.30e-01 | -0.1954 |
25934 | NIPSNAP3A | A001-C-014 | Human | Colorectum | FAP | 1.82e-03 | -8.78e-02 | 0.0135 |
25934 | NIPSNAP3A | A002-C-016 | Human | Colorectum | FAP | 3.85e-03 | -8.22e-02 | 0.0521 |
25934 | NIPSNAP3A | A002-C-116 | Human | Colorectum | FAP | 8.62e-04 | -5.63e-02 | -0.0452 |
25934 | NIPSNAP3A | LZE7T | Human | Esophagus | ESCC | 6.24e-07 | 3.90e-01 | 0.0667 |
25934 | NIPSNAP3A | LZE8T | Human | Esophagus | ESCC | 7.50e-08 | 1.36e-01 | 0.067 |
25934 | NIPSNAP3A | LZE20T | Human | Esophagus | ESCC | 1.15e-02 | 5.53e-02 | 0.0662 |
25934 | NIPSNAP3A | LZE24T | Human | Esophagus | ESCC | 2.62e-13 | 3.40e-01 | 0.0596 |
25934 | NIPSNAP3A | LZE6T | Human | Esophagus | ESCC | 4.95e-03 | 1.79e-01 | 0.0845 |
25934 | NIPSNAP3A | P2T-E | Human | Esophagus | ESCC | 3.56e-20 | 2.89e-01 | 0.1177 |
25934 | NIPSNAP3A | P4T-E | Human | Esophagus | ESCC | 1.86e-15 | 2.53e-01 | 0.1323 |
25934 | NIPSNAP3A | P5T-E | Human | Esophagus | ESCC | 1.77e-22 | 4.01e-01 | 0.1327 |
25934 | NIPSNAP3A | P8T-E | Human | Esophagus | ESCC | 5.37e-10 | 1.89e-01 | 0.0889 |
25934 | NIPSNAP3A | P9T-E | Human | Esophagus | ESCC | 8.81e-13 | 3.21e-01 | 0.1131 |
25934 | NIPSNAP3A | P10T-E | Human | Esophagus | ESCC | 1.76e-23 | 3.49e-01 | 0.116 |
25934 | NIPSNAP3A | P11T-E | Human | Esophagus | ESCC | 2.06e-11 | 4.75e-01 | 0.1426 |
25934 | NIPSNAP3A | P12T-E | Human | Esophagus | ESCC | 1.98e-09 | 1.30e-01 | 0.1122 |
25934 | NIPSNAP3A | P15T-E | Human | Esophagus | ESCC | 1.94e-04 | 8.82e-02 | 0.1149 |
25934 | NIPSNAP3A | P16T-E | Human | Esophagus | ESCC | 1.92e-11 | 1.13e-01 | 0.1153 |
25934 | NIPSNAP3A | P17T-E | Human | Esophagus | ESCC | 5.89e-06 | 2.57e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Liver | Cyst | ![]() |
Lung | IAC | ![]() |
Lung | AIS | ![]() |
Lung | AAH | ![]() |
Lung | MIAC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NIPSNAP3A | SNV | Missense_Mutation | novel | c.427N>C | p.Glu143Gln | p.E143Q | Q9UFN0 | protein_coding | tolerated(0.06) | benign(0.143) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NIPSNAP3A | SNV | Missense_Mutation | rs753323554 | c.466N>A | p.Gly156Ser | p.G156S | Q9UFN0 | protein_coding | deleterious(0) | probably_damaging(0.961) | TCGA-BH-A28O-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | CR |
NIPSNAP3A | SNV | Missense_Mutation | novel | c.454N>G | p.Gln152Glu | p.Q152E | Q9UFN0 | protein_coding | tolerated(0.08) | benign(0.186) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
NIPSNAP3A | SNV | Missense_Mutation | c.147N>T | p.Met49Ile | p.M49I | Q9UFN0 | protein_coding | tolerated(0.29) | benign(0.026) | TCGA-A6-4107-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5 | SD | |
NIPSNAP3A | SNV | Missense_Mutation | novel | c.523N>A | p.Leu175Ile | p.L175I | Q9UFN0 | protein_coding | tolerated(0.38) | benign(0.033) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NIPSNAP3A | SNV | Missense_Mutation | novel | c.178N>A | p.Ala60Thr | p.A60T | Q9UFN0 | protein_coding | deleterious(0) | benign(0.042) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NIPSNAP3A | SNV | Missense_Mutation | novel | c.298N>T | p.Arg100Trp | p.R100W | Q9UFN0 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
NIPSNAP3A | SNV | Missense_Mutation | c.364N>A | p.Asp122Asn | p.D122N | Q9UFN0 | protein_coding | tolerated(0.15) | possibly_damaging(0.511) | TCGA-D1-A15X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NIPSNAP3A | SNV | Missense_Mutation | rs775081506 | c.118N>T | p.Arg40Cys | p.R40C | Q9UFN0 | protein_coding | tolerated(0.08) | benign(0.365) | TCGA-D1-A16Y-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NIPSNAP3A | SNV | Missense_Mutation | rs777150822 | c.617G>A | p.Arg206His | p.R206H | Q9UFN0 | protein_coding | deleterious(0) | possibly_damaging(0.485) | TCGA-D1-A17U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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