![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: NECTIN3 |
Gene summary for NECTIN3 |
![]() |
Gene information | Species | Human | Gene symbol | NECTIN3 | Gene ID | 25945 |
Gene name | nectin cell adhesion molecule 3 | |
Gene Alias | CD113 | |
Cytomap | 3q13.13 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q9NQS3 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25945 | NECTIN3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.64e-18 | -5.54e-01 | 0.0155 |
25945 | NECTIN3 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.97e-07 | -6.15e-01 | -0.1207 |
25945 | NECTIN3 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.36e-02 | -4.71e-01 | -0.1526 |
25945 | NECTIN3 | HTA11_696_2000001011 | Human | Colorectum | AD | 7.87e-09 | -4.59e-01 | -0.1464 |
25945 | NECTIN3 | HTA11_866_2000001011 | Human | Colorectum | AD | 4.04e-10 | -5.09e-01 | -0.1001 |
25945 | NECTIN3 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.81e-02 | -5.31e-01 | -0.2061 |
25945 | NECTIN3 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.79e-15 | -6.31e-01 | 0.096 |
25945 | NECTIN3 | HTA11_8622_2000001021 | Human | Colorectum | SER | 4.34e-02 | -4.56e-01 | 0.0528 |
25945 | NECTIN3 | HTA11_10711_2000001011 | Human | Colorectum | AD | 7.13e-06 | -4.61e-01 | 0.0338 |
25945 | NECTIN3 | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.71e-14 | -5.82e-01 | 0.0674 |
25945 | NECTIN3 | HTA11_6818_2000001011 | Human | Colorectum | AD | 1.62e-04 | -5.70e-01 | 0.0112 |
25945 | NECTIN3 | HTA11_6818_2000001021 | Human | Colorectum | AD | 3.36e-06 | -5.26e-01 | 0.0588 |
25945 | NECTIN3 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.05e-07 | -4.07e-01 | 0.294 |
25945 | NECTIN3 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.89e-04 | -4.16e-01 | 0.3859 |
25945 | NECTIN3 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.26e-05 | -6.18e-01 | 0.2585 |
25945 | NECTIN3 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.15e-20 | -6.54e-01 | 0.3005 |
25945 | NECTIN3 | F007 | Human | Colorectum | FAP | 1.69e-07 | -5.10e-01 | 0.1176 |
25945 | NECTIN3 | A002-C-010 | Human | Colorectum | FAP | 2.17e-02 | -2.74e-01 | 0.242 |
25945 | NECTIN3 | A001-C-207 | Human | Colorectum | FAP | 2.19e-03 | -2.50e-01 | 0.1278 |
25945 | NECTIN3 | A015-C-203 | Human | Colorectum | FAP | 3.59e-30 | -6.42e-01 | -0.1294 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Liver | Cyst | ![]() |
Lung | IAC | ![]() |
Lung | AIS | ![]() |
Lung | AAH | ![]() |
Lung | MIAC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0072659 | Colorectum | AD | protein localization to plasma membrane | 122/3918 | 284/18723 | 2.86e-17 | 1.49e-14 | 122 |
GO:1990778 | Colorectum | AD | protein localization to cell periphery | 129/3918 | 333/18723 | 5.51e-14 | 1.15e-11 | 129 |
GO:0090150 | Colorectum | AD | establishment of protein localization to membrane | 100/3918 | 260/18723 | 6.01e-11 | 6.33e-09 | 100 |
GO:0061951 | Colorectum | AD | establishment of protein localization to plasma membrane | 31/3918 | 60/18723 | 1.37e-07 | 6.42e-06 | 31 |
GO:1902414 | Colorectum | AD | protein localization to cell junction | 31/3918 | 94/18723 | 4.30e-03 | 2.95e-02 | 31 |
GO:00726591 | Colorectum | SER | protein localization to plasma membrane | 92/2897 | 284/18723 | 6.36e-13 | 1.86e-10 | 92 |
GO:19907781 | Colorectum | SER | protein localization to cell periphery | 98/2897 | 333/18723 | 6.09e-11 | 9.57e-09 | 98 |
GO:00901501 | Colorectum | SER | establishment of protein localization to membrane | 68/2897 | 260/18723 | 5.55e-06 | 2.01e-04 | 68 |
GO:00619511 | Colorectum | SER | establishment of protein localization to plasma membrane | 20/2897 | 60/18723 | 4.60e-04 | 6.65e-03 | 20 |
GO:00726592 | Colorectum | MSS | protein localization to plasma membrane | 113/3467 | 284/18723 | 3.23e-17 | 1.55e-14 | 113 |
GO:19907782 | Colorectum | MSS | protein localization to cell periphery | 120/3467 | 333/18723 | 2.02e-14 | 5.47e-12 | 120 |
GO:00901502 | Colorectum | MSS | establishment of protein localization to membrane | 90/3467 | 260/18723 | 4.11e-10 | 3.49e-08 | 90 |
GO:00619512 | Colorectum | MSS | establishment of protein localization to plasma membrane | 28/3467 | 60/18723 | 5.80e-07 | 2.21e-05 | 28 |
GO:00726594 | Colorectum | FAP | protein localization to plasma membrane | 95/2622 | 284/18723 | 4.86e-17 | 9.93e-14 | 95 |
GO:19907784 | Colorectum | FAP | protein localization to cell periphery | 100/2622 | 333/18723 | 2.19e-14 | 2.68e-11 | 100 |
GO:00901504 | Colorectum | FAP | establishment of protein localization to membrane | 69/2622 | 260/18723 | 6.40e-08 | 4.54e-06 | 69 |
GO:00619513 | Colorectum | FAP | establishment of protein localization to plasma membrane | 24/2622 | 60/18723 | 6.30e-07 | 3.09e-05 | 24 |
GO:0048593 | Colorectum | FAP | camera-type eye morphogenesis | 28/2622 | 120/18723 | 3.98e-03 | 2.76e-02 | 28 |
GO:19024141 | Colorectum | FAP | protein localization to cell junction | 23/2622 | 94/18723 | 4.64e-03 | 3.14e-02 | 23 |
GO:00020891 | Colorectum | FAP | lens morphogenesis in camera-type eye | 8/2622 | 22/18723 | 7.51e-03 | 4.47e-02 | 8 |
Page: 1 2 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04520 | Colorectum | AD | Adherens junction | 50/2092 | 93/8465 | 1.52e-09 | 2.83e-08 | 1.81e-08 | 50 |
hsa045201 | Colorectum | AD | Adherens junction | 50/2092 | 93/8465 | 1.52e-09 | 2.83e-08 | 1.81e-08 | 50 |
hsa045202 | Colorectum | SER | Adherens junction | 37/1580 | 93/8465 | 1.54e-06 | 2.35e-05 | 1.71e-05 | 37 |
hsa045203 | Colorectum | SER | Adherens junction | 37/1580 | 93/8465 | 1.54e-06 | 2.35e-05 | 1.71e-05 | 37 |
hsa045204 | Colorectum | MSS | Adherens junction | 42/1875 | 93/8465 | 6.18e-07 | 9.01e-06 | 5.52e-06 | 42 |
hsa045205 | Colorectum | MSS | Adherens junction | 42/1875 | 93/8465 | 6.18e-07 | 9.01e-06 | 5.52e-06 | 42 |
hsa045208 | Colorectum | FAP | Adherens junction | 45/1404 | 93/8465 | 8.66e-13 | 2.89e-10 | 1.76e-10 | 45 |
hsa045209 | Colorectum | FAP | Adherens junction | 45/1404 | 93/8465 | 8.66e-13 | 2.89e-10 | 1.76e-10 | 45 |
hsa0452010 | Colorectum | CRC | Adherens junction | 37/1091 | 93/8465 | 5.72e-11 | 6.37e-09 | 4.32e-09 | 37 |
hsa0452011 | Colorectum | CRC | Adherens junction | 37/1091 | 93/8465 | 5.72e-11 | 6.37e-09 | 4.32e-09 | 37 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
NECTIN3 | NECTIN1 | NECTIN3_NECTIN1 | NECTIN | Cervix | CC |
NECTIN3 | NECTIN2 | NECTIN3_NECTIN2 | NECTIN | Cervix | CC |
NECTIN3 | TIGIT | NECTIN3_TIGIT | NECTIN | Cervix | CC |
NECTIN1 | NECTIN3 | NECTIN1_NECTIN3 | NECTIN | Cervix | CC |
NECTIN3 | NECTIN2 | NECTIN3_NECTIN2 | NECTIN | CRC | AD |
NECTIN3 | TIGIT | NECTIN3_TIGIT | NECTIN | CRC | AD |
NECTIN3 | NECTIN2 | NECTIN3_NECTIN2 | NECTIN | CRC | ADJ |
NECTIN3 | TIGIT | NECTIN3_TIGIT | NECTIN | CRC | ADJ |
NECTIN3 | NECTIN2 | NECTIN3_NECTIN2 | NECTIN | CRC | Healthy |
NECTIN3 | NECTIN1 | NECTIN3_NECTIN1 | NECTIN | CRC | MSI-H |
NECTIN3 | NECTIN2 | NECTIN3_NECTIN2 | NECTIN | CRC | MSI-H |
NECTIN3 | PVR | NECTIN3_PVR | NECTIN | CRC | MSI-H |
NECTIN3 | TIGIT | NECTIN3_TIGIT | NECTIN | CRC | MSI-H |
NECTIN1 | NECTIN3 | NECTIN1_NECTIN3 | NECTIN | CRC | MSI-H |
NECTIN3 | NECTIN1 | NECTIN3_NECTIN1 | NECTIN | CRC | MSS |
NECTIN3 | NECTIN2 | NECTIN3_NECTIN2 | NECTIN | CRC | MSS |
NECTIN1 | NECTIN3 | NECTIN1_NECTIN3 | NECTIN | CRC | MSS |
NECTIN3 | NECTIN2 | NECTIN3_NECTIN2 | NECTIN | CRC | SER |
NECTIN3 | TIGIT | NECTIN3_TIGIT | NECTIN | CRC | SER |
NECTIN3 | NECTIN2 | NECTIN3_NECTIN2 | NECTIN | Endometrium | ADJ |
Page: 1 2 3 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NECTIN3 | SNV | Missense_Mutation | novel | c.21N>C | p.Gln7His | p.Q7H | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.829) | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response | |
NECTIN3 | SNV | Missense_Mutation | novel | c.1144G>C | p.Asp382His | p.D382H | Q9NQS3 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
NECTIN3 | SNV | Missense_Mutation | c.264N>C | p.Gln88His | p.Q88H | Q9NQS3 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-A7-A6VV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | CR | |
NECTIN3 | SNV | Missense_Mutation | c.1034N>T | p.Gly345Val | p.G345V | Q9NQS3 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AR-A0TY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | PD | |
NECTIN3 | SNV | Missense_Mutation | c.787T>G | p.Leu263Val | p.L263V | Q9NQS3 | protein_coding | deleterious(0) | possibly_damaging(0.817) | TCGA-AR-A0U3-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
NECTIN3 | SNV | Missense_Mutation | c.904T>G | p.Ser302Ala | p.S302A | Q9NQS3 | protein_coding | deleterious(0.01) | benign(0.078) | TCGA-C8-A26X-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
NECTIN3 | insertion | Frame_Shift_Ins | novel | c.217_218insCTGAGGTAGAAGATTCAGTTACATC | p.Asn73ThrfsTer17 | p.N73Tfs*17 | Q9NQS3 | protein_coding | TCGA-AR-A0TU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Doxorubicin | SD | ||
NECTIN3 | insertion | Nonsense_Mutation | novel | c.1629_1630insTAAGAAACTCAGGTTTGTATGGTAATTATGGAATAAAT | p.Arg544Ter | p.R544* | Q9NQS3 | protein_coding | TCGA-BH-A0B1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin | SD | ||
NECTIN3 | SNV | Missense_Mutation | rs15611 | c.1295G>A | p.Arg432Gln | p.R432Q | Q9NQS3 | protein_coding | tolerated(0.3) | benign(0.097) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
NECTIN3 | SNV | Missense_Mutation | novel | c.547N>A | p.Asp183Asn | p.D183N | Q9NQS3 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-C5-A1BK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |