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Gene: MTRNR2L2 |
Gene summary for MTRNR2L2 |
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Gene information | Species | Human | Gene symbol | MTRNR2L2 | Gene ID | 100462981 |
Gene name | MT-RNR2 like 2 | |
Gene Alias | HN2 | |
Cytomap | 5q14.1 | |
Gene Type | protein-coding | GO ID | GO:0006915 | UniProtAcc | P0CJ69 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
100462981 | MTRNR2L2 | HCC1 | Human | Liver | HCC | 1.91e-39 | 2.26e+00 | 0.5336 |
100462981 | MTRNR2L2 | HCC2 | Human | Liver | HCC | 8.82e-47 | 2.20e+00 | 0.5341 |
100462981 | MTRNR2L2 | HCC5 | Human | Liver | HCC | 2.39e-83 | 3.45e+00 | 0.4932 |
100462981 | MTRNR2L2 | Pt13.a | Human | Liver | HCC | 4.52e-18 | 4.10e-01 | 0.021 |
100462981 | MTRNR2L2 | Pt13.b | Human | Liver | HCC | 1.79e-23 | 4.32e-01 | 0.0251 |
100462981 | MTRNR2L2 | Pt13.c | Human | Liver | HCC | 4.48e-22 | 8.03e-01 | 0.0076 |
100462981 | MTRNR2L2 | Pt14.a | Human | Liver | HCC | 7.31e-20 | 7.29e-01 | 0.0169 |
100462981 | MTRNR2L2 | Pt14.b | Human | Liver | HCC | 4.52e-16 | 5.28e-01 | 0.018 |
100462981 | MTRNR2L2 | Pt14.d | Human | Liver | HCC | 6.07e-44 | 8.19e-01 | 0.0143 |
100462981 | MTRNR2L2 | Pt1_Superficial | Human | Stomach | GC | 1.20e-20 | 8.04e-01 | 0.1036 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Liver | Cyst | ![]() |
Lung | IAC | ![]() |
Lung | AIS | ![]() |
Lung | AAH | ![]() |
Lung | MIAC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0097194 | Liver | HCC | execution phase of apoptosis | 48/7958 | 85/18723 | 6.47e-03 | 2.63e-02 | 48 |
GO:1900117 | Liver | HCC | regulation of execution phase of apoptosis | 19/7958 | 29/18723 | 1.05e-02 | 3.89e-02 | 19 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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