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Gene: LEMD1 |
Gene summary for LEMD1 |
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Gene information | Species | Human | Gene symbol | LEMD1 | Gene ID | 93273 |
Gene name | LEM domain containing 1 | |
Gene Alias | CT50 | |
Cytomap | 1q32.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q68G75 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
93273 | LEMD1 | LZE8T | Human | Esophagus | ESCC | 1.08e-12 | 4.11e-01 | 0.067 |
93273 | LEMD1 | P1T-E | Human | Esophagus | ESCC | 1.45e-10 | 5.56e-01 | 0.0875 |
93273 | LEMD1 | P2T-E | Human | Esophagus | ESCC | 4.18e-35 | 6.82e-01 | 0.1177 |
93273 | LEMD1 | P17T-E | Human | Esophagus | ESCC | 1.49e-02 | 2.24e-01 | 0.1278 |
93273 | LEMD1 | P19T-E | Human | Esophagus | ESCC | 5.57e-05 | 7.07e-01 | 0.1662 |
93273 | LEMD1 | P21T-E | Human | Esophagus | ESCC | 2.39e-07 | 2.49e-01 | 0.1617 |
93273 | LEMD1 | P23T-E | Human | Esophagus | ESCC | 8.01e-24 | 7.15e-01 | 0.108 |
93273 | LEMD1 | P24T-E | Human | Esophagus | ESCC | 1.23e-03 | 1.26e-01 | 0.1287 |
93273 | LEMD1 | P31T-E | Human | Esophagus | ESCC | 9.57e-21 | 4.57e-01 | 0.1251 |
93273 | LEMD1 | P32T-E | Human | Esophagus | ESCC | 1.71e-09 | 2.69e-01 | 0.1666 |
93273 | LEMD1 | P36T-E | Human | Esophagus | ESCC | 3.71e-09 | 3.59e-01 | 0.1187 |
93273 | LEMD1 | P40T-E | Human | Esophagus | ESCC | 5.68e-07 | 2.28e-01 | 0.109 |
93273 | LEMD1 | P42T-E | Human | Esophagus | ESCC | 8.55e-05 | 2.13e-01 | 0.1175 |
93273 | LEMD1 | P47T-E | Human | Esophagus | ESCC | 2.82e-04 | 1.17e-01 | 0.1067 |
93273 | LEMD1 | P48T-E | Human | Esophagus | ESCC | 2.34e-11 | 3.51e-01 | 0.0959 |
93273 | LEMD1 | P54T-E | Human | Esophagus | ESCC | 3.18e-08 | 2.42e-01 | 0.0975 |
93273 | LEMD1 | P62T-E | Human | Esophagus | ESCC | 4.72e-79 | 1.55e+00 | 0.1302 |
93273 | LEMD1 | P76T-E | Human | Esophagus | ESCC | 4.22e-35 | 7.30e-01 | 0.1207 |
93273 | LEMD1 | P82T-E | Human | Esophagus | ESCC | 1.40e-05 | 4.23e-01 | 0.1072 |
93273 | LEMD1 | P83T-E | Human | Esophagus | ESCC | 3.17e-02 | 1.23e-01 | 0.1738 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Liver | Cyst | ![]() |
Lung | IAC | ![]() |
Lung | AIS | ![]() |
Lung | AAH | ![]() |
Lung | MIAC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LEMD1 | SNV | Missense_Mutation | rs16855539 | c.218N>C | p.Ile73Thr | p.I73T | Q68G75 | protein_coding | tolerated(0.1) | benign(0.03) | TCGA-LL-A441-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
LEMD1 | deletion | In_Frame_Del | novel | c.114_122delAGTACAGTT | p.Val39_Leu41del | p.V39_L41del | Q68G75 | protein_coding | TCGA-LL-A8F5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | ||
LEMD1 | SNV | Missense_Mutation | novel | c.89N>G | p.Thr30Ser | p.T30S | Q68G75 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LEMD1 | SNV | Missense_Mutation | c.361N>A | p.Ala121Thr | p.A121T | Q68G75 | protein_coding | tolerated(0.27) | benign(0.025) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
LEMD1 | deletion | Frame_Shift_Del | rs774476336 | c.110delN | p.Lys37SerfsTer2 | p.K37Sfs*2 | Q68G75 | protein_coding | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
LEMD1 | SNV | Missense_Mutation | novel | c.116N>C | p.Val39Ala | p.V39A | Q68G75 | protein_coding | tolerated(0.07) | benign(0.09) | TCGA-AP-A1DO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LEMD1 | SNV | Missense_Mutation | novel | c.492C>A | p.Phe164Leu | p.F164L | Q68G75 | protein_coding | tolerated(0.12) | benign(0.019) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
LEMD1 | SNV | Missense_Mutation | novel | c.302N>A | p.Ala101Asp | p.A101D | Q68G75 | protein_coding | tolerated(0.06) | benign(0.216) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LEMD1 | SNV | Missense_Mutation | novel | c.157N>G | p.Asn53Asp | p.N53D | Q68G75 | protein_coding | tolerated(0.08) | benign(0.009) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
LEMD1 | SNV | Missense_Mutation | novel | c.281N>T | p.Ala94Val | p.A94V | Q68G75 | protein_coding | tolerated(0.12) | possibly_damaging(0.476) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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