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Gene: LACTB |
Gene summary for LACTB |
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Gene information | Species | Human | Gene symbol | LACTB | Gene ID | 114294 |
Gene name | lactamase beta | |
Gene Alias | G24 | |
Cytomap | 15q22.2 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | P83111 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
114294 | LACTB | LZE4T | Human | Esophagus | ESCC | 1.56e-02 | 3.90e-02 | 0.0811 |
114294 | LACTB | LZE24T | Human | Esophagus | ESCC | 1.08e-04 | 1.55e-01 | 0.0596 |
114294 | LACTB | P1T-E | Human | Esophagus | ESCC | 6.80e-06 | 2.24e-01 | 0.0875 |
114294 | LACTB | P2T-E | Human | Esophagus | ESCC | 1.54e-22 | 2.99e-01 | 0.1177 |
114294 | LACTB | P4T-E | Human | Esophagus | ESCC | 9.69e-21 | 5.19e-01 | 0.1323 |
114294 | LACTB | P5T-E | Human | Esophagus | ESCC | 1.92e-35 | 6.64e-01 | 0.1327 |
114294 | LACTB | P8T-E | Human | Esophagus | ESCC | 3.00e-10 | 1.51e-01 | 0.0889 |
114294 | LACTB | P9T-E | Human | Esophagus | ESCC | 5.21e-07 | 2.37e-01 | 0.1131 |
114294 | LACTB | P10T-E | Human | Esophagus | ESCC | 5.23e-12 | 1.16e-01 | 0.116 |
114294 | LACTB | P11T-E | Human | Esophagus | ESCC | 6.68e-11 | 5.02e-01 | 0.1426 |
114294 | LACTB | P12T-E | Human | Esophagus | ESCC | 1.68e-17 | 2.53e-01 | 0.1122 |
114294 | LACTB | P15T-E | Human | Esophagus | ESCC | 1.50e-16 | 2.08e-01 | 0.1149 |
114294 | LACTB | P16T-E | Human | Esophagus | ESCC | 6.81e-12 | 1.46e-01 | 0.1153 |
114294 | LACTB | P17T-E | Human | Esophagus | ESCC | 9.25e-04 | 1.83e-01 | 0.1278 |
114294 | LACTB | P19T-E | Human | Esophagus | ESCC | 1.12e-02 | 3.63e-01 | 0.1662 |
114294 | LACTB | P21T-E | Human | Esophagus | ESCC | 9.78e-13 | 2.24e-01 | 0.1617 |
114294 | LACTB | P22T-E | Human | Esophagus | ESCC | 6.43e-16 | 1.23e-01 | 0.1236 |
114294 | LACTB | P23T-E | Human | Esophagus | ESCC | 6.18e-15 | 2.46e-01 | 0.108 |
114294 | LACTB | P24T-E | Human | Esophagus | ESCC | 5.26e-16 | 3.51e-01 | 0.1287 |
114294 | LACTB | P26T-E | Human | Esophagus | ESCC | 2.12e-34 | 2.40e-01 | 0.1276 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Liver | Cyst | ![]() |
Lung | IAC | ![]() |
Lung | AIS | ![]() |
Lung | AAH | ![]() |
Lung | MIAC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00905013 | Esophagus | ESCC | RNA phosphodiester bond hydrolysis | 110/8552 | 152/18723 | 1.95e-11 | 6.81e-10 | 110 |
GO:00903053 | Esophagus | ESCC | nucleic acid phosphodiester bond hydrolysis | 163/8552 | 261/18723 | 3.07e-08 | 5.73e-07 | 163 |
GO:00905023 | Esophagus | ESCC | RNA phosphodiester bond hydrolysis, endonucleolytic | 55/8552 | 82/18723 | 7.34e-05 | 5.51e-04 | 55 |
GO:00192168 | Esophagus | ESCC | regulation of lipid metabolic process | 172/8552 | 331/18723 | 1.20e-02 | 4.02e-02 | 172 |
GO:001921611 | Liver | Cirrhotic | regulation of lipid metabolic process | 119/4634 | 331/18723 | 3.05e-06 | 5.39e-05 | 119 |
GO:0090501 | Liver | Cirrhotic | RNA phosphodiester bond hydrolysis | 54/4634 | 152/18723 | 1.89e-03 | 1.19e-02 | 54 |
GO:00905011 | Liver | HCC | RNA phosphodiester bond hydrolysis | 101/7958 | 152/18723 | 1.99e-09 | 5.63e-08 | 101 |
GO:0090305 | Liver | HCC | nucleic acid phosphodiester bond hydrolysis | 152/7958 | 261/18723 | 1.90e-07 | 3.46e-06 | 152 |
GO:00192162 | Liver | HCC | regulation of lipid metabolic process | 181/7958 | 331/18723 | 4.58e-06 | 5.79e-05 | 181 |
GO:0090502 | Liver | HCC | RNA phosphodiester bond hydrolysis, endonucleolytic | 52/7958 | 82/18723 | 1.06e-04 | 9.08e-04 | 52 |
GO:00905012 | Oral cavity | OSCC | RNA phosphodiester bond hydrolysis | 95/7305 | 152/18723 | 3.65e-09 | 8.22e-08 | 95 |
GO:00903052 | Oral cavity | OSCC | nucleic acid phosphodiester bond hydrolysis | 142/7305 | 261/18723 | 2.90e-07 | 4.43e-06 | 142 |
GO:00192167 | Oral cavity | OSCC | regulation of lipid metabolic process | 154/7305 | 331/18723 | 3.00e-03 | 1.30e-02 | 154 |
GO:00905022 | Oral cavity | OSCC | RNA phosphodiester bond hydrolysis, endonucleolytic | 44/7305 | 82/18723 | 4.95e-03 | 1.94e-02 | 44 |
GO:009050111 | Oral cavity | LP | RNA phosphodiester bond hydrolysis | 63/4623 | 152/18723 | 3.88e-06 | 8.13e-05 | 63 |
GO:00903051 | Oral cavity | LP | nucleic acid phosphodiester bond hydrolysis | 92/4623 | 261/18723 | 8.07e-05 | 1.04e-03 | 92 |
GO:00905021 | Oral cavity | LP | RNA phosphodiester bond hydrolysis, endonucleolytic | 31/4623 | 82/18723 | 5.66e-03 | 3.41e-02 | 31 |
GO:001921614 | Oral cavity | EOLP | regulation of lipid metabolic process | 54/2218 | 331/18723 | 9.09e-03 | 4.15e-02 | 54 |
GO:00905014 | Skin | cSCC | RNA phosphodiester bond hydrolysis | 71/4864 | 152/18723 | 2.72e-08 | 7.41e-07 | 71 |
GO:00903054 | Skin | cSCC | nucleic acid phosphodiester bond hydrolysis | 97/4864 | 261/18723 | 4.08e-05 | 4.34e-04 | 97 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LACTB | SNV | Missense_Mutation | c.721N>T | p.Met241Leu | p.M241L | P83111 | protein_coding | tolerated(0.98) | benign(0.003) | TCGA-AN-A0XV-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
LACTB | SNV | Missense_Mutation | c.1556N>C | p.Val519Ala | p.V519A | P83111 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AO-A0J3-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cyclophosphamide | SD | |
LACTB | SNV | Missense_Mutation | c.660T>G | p.Ile220Met | p.I220M | P83111 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-D8-A1JL-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LACTB | SNV | Missense_Mutation | c.1140N>C | p.Lys380Asn | p.K380N | P83111 | protein_coding | tolerated(0.24) | benign(0.09) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
LACTB | SNV | Missense_Mutation | rs755059722 | c.871N>A | p.Glu291Lys | p.E291K | P83111 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
LACTB | SNV | Missense_Mutation | c.694N>A | p.Glu232Lys | p.E232K | P83111 | protein_coding | tolerated(0.14) | benign(0.09) | TCGA-D5-5541-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | calcium | SD | |
LACTB | SNV | Missense_Mutation | novel | c.816A>T | p.Glu272Asp | p.E272D | P83111 | protein_coding | tolerated(0.17) | benign(0) | TCGA-T9-A92H-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
LACTB | SNV | Missense_Mutation | rs566925626 | c.1165N>A | p.Val389Met | p.V389M | P83111 | protein_coding | deleterious(0) | probably_damaging(0.91) | TCGA-AG-3882-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LACTB | SNV | Missense_Mutation | novel | c.482N>A | p.Arg161Gln | p.R161Q | P83111 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
LACTB | SNV | Missense_Mutation | rs755059722 | c.871G>A | p.Glu291Lys | p.E291K | P83111 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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