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Gene: KRCC1 |
Gene summary for KRCC1 |
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Gene information | Species | Human | Gene symbol | KRCC1 | Gene ID | 51315 |
Gene name | lysine rich coiled-coil 1 | |
Gene Alias | CHBP2 | |
Cytomap | 2p11.2 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | A0A024R5P4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51315 | KRCC1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.86e-02 | 4.69e-01 | -0.0811 |
51315 | KRCC1 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.57e-06 | 5.68e-01 | -0.1088 |
51315 | KRCC1 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.06e-13 | 5.83e-01 | -0.1954 |
51315 | KRCC1 | A015-C-203 | Human | Colorectum | FAP | 9.40e-13 | -2.88e-01 | -0.1294 |
51315 | KRCC1 | A002-C-201 | Human | Colorectum | FAP | 1.11e-02 | -1.88e-01 | 0.0324 |
51315 | KRCC1 | A001-C-108 | Human | Colorectum | FAP | 2.17e-06 | -8.08e-02 | -0.0272 |
51315 | KRCC1 | A002-C-205 | Human | Colorectum | FAP | 4.64e-07 | -2.04e-01 | -0.1236 |
51315 | KRCC1 | A015-C-006 | Human | Colorectum | FAP | 1.24e-04 | -2.95e-01 | -0.0994 |
51315 | KRCC1 | A015-C-106 | Human | Colorectum | FAP | 2.45e-03 | -1.69e-01 | -0.0511 |
51315 | KRCC1 | A002-C-114 | Human | Colorectum | FAP | 1.93e-04 | -2.00e-01 | -0.1561 |
51315 | KRCC1 | A015-C-104 | Human | Colorectum | FAP | 1.22e-12 | -1.36e-01 | -0.1899 |
51315 | KRCC1 | A001-C-014 | Human | Colorectum | FAP | 1.09e-04 | -1.63e-01 | 0.0135 |
51315 | KRCC1 | A002-C-016 | Human | Colorectum | FAP | 1.65e-09 | -8.37e-02 | 0.0521 |
51315 | KRCC1 | A015-C-002 | Human | Colorectum | FAP | 3.07e-03 | -1.96e-01 | -0.0763 |
51315 | KRCC1 | A001-C-203 | Human | Colorectum | FAP | 5.37e-04 | -4.67e-02 | -0.0481 |
51315 | KRCC1 | A002-C-116 | Human | Colorectum | FAP | 1.28e-13 | -1.70e-01 | -0.0452 |
51315 | KRCC1 | A014-C-008 | Human | Colorectum | FAP | 6.91e-03 | -1.05e-01 | -0.191 |
51315 | KRCC1 | A018-E-020 | Human | Colorectum | FAP | 8.04e-08 | -2.67e-01 | -0.2034 |
51315 | KRCC1 | F034 | Human | Colorectum | FAP | 2.96e-08 | -1.49e-01 | -0.0665 |
51315 | KRCC1 | CRC-3-11773 | Human | Colorectum | CRC | 2.15e-10 | -2.93e-01 | 0.2564 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Liver | Cyst | ![]() |
Lung | IAC | ![]() |
Lung | AIS | ![]() |
Lung | AAH | ![]() |
Lung | MIAC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KRCC1 | SNV | Missense_Mutation | novel | c.37N>T | p.Asp13Tyr | p.D13Y | Q9NPI7 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-A8-A09Q-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD |
KRCC1 | SNV | Missense_Mutation | c.15N>T | p.Lys5Asn | p.K5N | Q9NPI7 | protein_coding | tolerated(0.08) | benign(0.051) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
KRCC1 | SNV | Missense_Mutation | c.490C>T | p.Pro164Ser | p.P164S | Q9NPI7 | protein_coding | tolerated(0.76) | benign(0.124) | TCGA-AH-6897-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
KRCC1 | SNV | Missense_Mutation | novel | c.549N>A | p.Ser183Arg | p.S183R | Q9NPI7 | protein_coding | tolerated(0.19) | benign(0.005) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
KRCC1 | SNV | Missense_Mutation | novel | c.357N>A | p.Asn119Lys | p.N119K | Q9NPI7 | protein_coding | deleterious(0.01) | benign(0.232) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
KRCC1 | SNV | Missense_Mutation | rs147560562 | c.164C>T | p.Thr55Met | p.T55M | Q9NPI7 | protein_coding | deleterious(0.02) | benign(0.001) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KRCC1 | SNV | Missense_Mutation | rs779719379 | c.320N>T | p.Thr107Met | p.T107M | Q9NPI7 | protein_coding | deleterious(0.01) | possibly_damaging(0.897) | TCGA-AJ-A8CW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KRCC1 | SNV | Missense_Mutation | c.635N>C | p.Glu212Ala | p.E212A | Q9NPI7 | protein_coding | tolerated(0.3) | benign(0.021) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
KRCC1 | SNV | Missense_Mutation | novel | c.764N>A | p.Ser255Tyr | p.S255Y | Q9NPI7 | protein_coding | deleterious(0) | possibly_damaging(0.895) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
KRCC1 | SNV | Missense_Mutation | novel | c.670N>T | p.Asp224Tyr | p.D224Y | Q9NPI7 | protein_coding | deleterious(0.01) | possibly_damaging(0.8) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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