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Gene: ISCA2 |
Gene summary for ISCA2 |
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Gene information | Species | Human | Gene symbol | ISCA2 | Gene ID | 122961 |
Gene name | iron-sulfur cluster assembly 2 | |
Gene Alias | HBLD1 | |
Cytomap | 14q24.3 | |
Gene Type | protein-coding | GO ID | GO:0006790 | UniProtAcc | Q86U28 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
122961 | ISCA2 | LZE4T | Human | Esophagus | ESCC | 9.37e-21 | 5.72e-01 | 0.0811 |
122961 | ISCA2 | LZE5T | Human | Esophagus | ESCC | 8.82e-11 | 5.94e-01 | 0.0514 |
122961 | ISCA2 | LZE7T | Human | Esophagus | ESCC | 5.42e-04 | 1.59e-01 | 0.0667 |
122961 | ISCA2 | LZE8T | Human | Esophagus | ESCC | 4.83e-09 | 3.79e-01 | 0.067 |
122961 | ISCA2 | LZE20T | Human | Esophagus | ESCC | 1.63e-15 | 5.90e-01 | 0.0662 |
122961 | ISCA2 | LZE22D1 | Human | Esophagus | HGIN | 1.02e-03 | 2.02e-01 | 0.0595 |
122961 | ISCA2 | LZE22T | Human | Esophagus | ESCC | 3.16e-11 | 9.11e-01 | 0.068 |
122961 | ISCA2 | LZE24T | Human | Esophagus | ESCC | 8.07e-34 | 8.45e-01 | 0.0596 |
122961 | ISCA2 | LZE21T | Human | Esophagus | ESCC | 1.81e-04 | 4.73e-01 | 0.0655 |
122961 | ISCA2 | LZE6T | Human | Esophagus | ESCC | 1.52e-04 | 3.33e-01 | 0.0845 |
122961 | ISCA2 | P1T-E | Human | Esophagus | ESCC | 1.05e-07 | 5.05e-01 | 0.0875 |
122961 | ISCA2 | P2T-E | Human | Esophagus | ESCC | 8.90e-49 | 6.93e-01 | 0.1177 |
122961 | ISCA2 | P4T-E | Human | Esophagus | ESCC | 1.49e-48 | 1.15e+00 | 0.1323 |
122961 | ISCA2 | P5T-E | Human | Esophagus | ESCC | 3.61e-41 | 7.56e-01 | 0.1327 |
122961 | ISCA2 | P8T-E | Human | Esophagus | ESCC | 1.17e-37 | 7.65e-01 | 0.0889 |
122961 | ISCA2 | P9T-E | Human | Esophagus | ESCC | 5.25e-21 | 4.43e-01 | 0.1131 |
122961 | ISCA2 | P10T-E | Human | Esophagus | ESCC | 1.86e-33 | 5.42e-01 | 0.116 |
122961 | ISCA2 | P11T-E | Human | Esophagus | ESCC | 7.01e-17 | 6.91e-01 | 0.1426 |
122961 | ISCA2 | P12T-E | Human | Esophagus | ESCC | 2.72e-63 | 1.06e+00 | 0.1122 |
122961 | ISCA2 | P15T-E | Human | Esophagus | ESCC | 3.96e-67 | 1.25e+00 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Liver | Cyst | ![]() |
Lung | IAC | ![]() |
Lung | AIS | ![]() |
Lung | AAH | ![]() |
Lung | MIAC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005160417 | Esophagus | HGIN | protein maturation | 68/2587 | 294/18723 | 9.77e-06 | 2.86e-04 | 68 |
GO:00974282 | Esophagus | HGIN | protein maturation by iron-sulfur cluster transfer | 8/2587 | 16/18723 | 6.00e-04 | 8.41e-03 | 8 |
GO:00162263 | Esophagus | HGIN | iron-sulfur cluster assembly | 10/2587 | 26/18723 | 1.60e-03 | 1.79e-02 | 10 |
GO:00311633 | Esophagus | HGIN | metallo-sulfur cluster assembly | 10/2587 | 26/18723 | 1.60e-03 | 1.79e-02 | 10 |
GO:005160418 | Esophagus | ESCC | protein maturation | 189/8552 | 294/18723 | 7.64e-11 | 2.39e-09 | 189 |
GO:00067906 | Esophagus | ESCC | sulfur compound metabolic process | 201/8552 | 339/18723 | 2.64e-07 | 3.94e-06 | 201 |
GO:001622611 | Esophagus | ESCC | iron-sulfur cluster assembly | 21/8552 | 26/18723 | 2.69e-04 | 1.63e-03 | 21 |
GO:003116311 | Esophagus | ESCC | metallo-sulfur cluster assembly | 21/8552 | 26/18723 | 2.69e-04 | 1.63e-03 | 21 |
GO:009742811 | Esophagus | ESCC | protein maturation by iron-sulfur cluster transfer | 14/8552 | 16/18723 | 6.78e-04 | 3.56e-03 | 14 |
GO:00516046 | Liver | Cirrhotic | protein maturation | 121/4634 | 294/18723 | 3.54e-10 | 1.68e-08 | 121 |
GO:000679011 | Liver | Cirrhotic | sulfur compound metabolic process | 129/4634 | 339/18723 | 3.06e-08 | 1.04e-06 | 129 |
GO:000679021 | Liver | HCC | sulfur compound metabolic process | 212/7958 | 339/18723 | 5.60e-14 | 3.39e-12 | 212 |
GO:005160412 | Liver | HCC | protein maturation | 171/7958 | 294/18723 | 3.80e-08 | 8.30e-07 | 171 |
GO:0016226 | Liver | HCC | iron-sulfur cluster assembly | 18/7958 | 26/18723 | 5.37e-03 | 2.24e-02 | 18 |
GO:0031163 | Liver | HCC | metallo-sulfur cluster assembly | 18/7958 | 26/18723 | 5.37e-03 | 2.24e-02 | 18 |
GO:005160410 | Oral cavity | OSCC | protein maturation | 170/7305 | 294/18723 | 3.97e-11 | 1.28e-09 | 170 |
GO:00067905 | Oral cavity | OSCC | sulfur compound metabolic process | 168/7305 | 339/18723 | 4.50e-05 | 3.84e-04 | 168 |
GO:00162262 | Oral cavity | OSCC | iron-sulfur cluster assembly | 19/7305 | 26/18723 | 4.46e-04 | 2.70e-03 | 19 |
GO:00311632 | Oral cavity | OSCC | metallo-sulfur cluster assembly | 19/7305 | 26/18723 | 4.46e-04 | 2.70e-03 | 19 |
GO:0097428 | Oral cavity | OSCC | protein maturation by iron-sulfur cluster transfer | 11/7305 | 16/18723 | 1.56e-02 | 4.99e-02 | 11 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ISCA2 | SNV | Missense_Mutation | novel | c.389N>T | p.Ser130Ile | p.S130I | Q86U28 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ISCA2 | SNV | Missense_Mutation | novel | c.355N>C | p.Ala119Pro | p.A119P | Q86U28 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-AA-A01I-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ISCA2 | SNV | Missense_Mutation | novel | c.356N>T | p.Ala119Val | p.A119V | Q86U28 | protein_coding | deleterious(0) | probably_damaging(0.936) | TCGA-AA-A01I-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ISCA2 | SNV | Missense_Mutation | c.46N>A | p.Ala16Thr | p.A16T | Q86U28 | protein_coding | tolerated(0.38) | benign(0) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ISCA2 | SNV | Missense_Mutation | rs200054853 | c.239C>T | p.Ser80Phe | p.S80F | Q86U28 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AG-A00Y-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ISCA2 | SNV | Missense_Mutation | novel | c.179T>G | p.Leu60Arg | p.L60R | Q86U28 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
ISCA2 | SNV | Missense_Mutation | novel | c.4G>A | p.Ala2Thr | p.A2T | Q86U28 | protein_coding | deleterious(0.01) | benign(0.438) | TCGA-AX-A2HJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ISCA2 | SNV | Missense_Mutation | novel | c.52N>G | p.Thr18Ala | p.T18A | Q86U28 | protein_coding | tolerated(0.65) | benign(0) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
ISCA2 | SNV | Missense_Mutation | c.31N>C | p.Ala11Pro | p.A11P | Q86U28 | protein_coding | tolerated(0.25) | possibly_damaging(0.58) | TCGA-34-5231-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ISCA2 | SNV | Missense_Mutation | rs730882246 | c.229N>A | p.Gly77Ser | p.G77S | Q86U28 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-HU-A4GU-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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