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Gene: IRGQ |
Gene summary for IRGQ |
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Gene information | Species | Human | Gene symbol | IRGQ | Gene ID | 126298 |
Gene name | immunity related GTPase Q | |
Gene Alias | FKSG27 | |
Cytomap | 19q13.31 | |
Gene Type | protein-coding | GO ID | GO:0000166 | UniProtAcc | Q8WZA9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
126298 | IRGQ | HCC1_Meng | Human | Liver | HCC | 3.11e-22 | 1.30e-02 | 0.0246 |
126298 | IRGQ | HCC2_Meng | Human | Liver | HCC | 1.24e-04 | 7.17e-03 | 0.0107 |
126298 | IRGQ | HCC1 | Human | Liver | HCC | 1.01e-20 | 3.10e+00 | 0.5336 |
126298 | IRGQ | HCC2 | Human | Liver | HCC | 2.89e-26 | 2.38e+00 | 0.5341 |
126298 | IRGQ | HCC5 | Human | Liver | HCC | 8.46e-14 | 1.30e+00 | 0.4932 |
126298 | IRGQ | S014 | Human | Liver | HCC | 2.44e-06 | 2.82e-01 | 0.2254 |
126298 | IRGQ | S015 | Human | Liver | HCC | 1.79e-04 | 2.19e-01 | 0.2375 |
126298 | IRGQ | S016 | Human | Liver | HCC | 5.86e-03 | 1.51e-01 | 0.2243 |
126298 | IRGQ | S027 | Human | Liver | HCC | 5.63e-09 | 5.91e-01 | 0.2446 |
126298 | IRGQ | S028 | Human | Liver | HCC | 7.62e-17 | 5.88e-01 | 0.2503 |
126298 | IRGQ | S029 | Human | Liver | HCC | 4.49e-15 | 4.85e-01 | 0.2581 |
126298 | IRGQ | male-WTA | Human | Thyroid | PTC | 3.36e-04 | 6.13e-02 | 0.1037 |
126298 | IRGQ | PTC01 | Human | Thyroid | PTC | 1.28e-07 | 8.98e-02 | 0.1899 |
126298 | IRGQ | PTC04 | Human | Thyroid | PTC | 7.29e-14 | 1.72e-01 | 0.1927 |
126298 | IRGQ | PTC05 | Human | Thyroid | PTC | 1.19e-05 | 2.88e-01 | 0.2065 |
126298 | IRGQ | PTC06 | Human | Thyroid | PTC | 7.19e-14 | 3.72e-01 | 0.2057 |
126298 | IRGQ | PTC07 | Human | Thyroid | PTC | 2.21e-15 | 2.18e-01 | 0.2044 |
126298 | IRGQ | ATC12 | Human | Thyroid | ATC | 1.81e-04 | 4.31e-02 | 0.34 |
126298 | IRGQ | ATC13 | Human | Thyroid | ATC | 3.64e-68 | 1.27e+00 | 0.34 |
126298 | IRGQ | ATC2 | Human | Thyroid | ATC | 3.31e-07 | 6.62e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Liver | Cyst | ![]() |
Lung | IAC | ![]() |
Lung | AIS | ![]() |
Lung | AAH | ![]() |
Lung | MIAC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IRGQ | insertion | Frame_Shift_Ins | rs779595401 | c.876_877insAGCTCTGCTG | p.His293SerfsTer21 | p.H293Sfs*21 | Q8WZA9 | protein_coding | TCGA-A2-A04Q-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
IRGQ | insertion | Frame_Shift_Ins | rs779595401 | c.876_877insAGCTCTGCTG | p.His293SerfsTer21 | p.H293Sfs*21 | Q8WZA9 | protein_coding | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD | ||
IRGQ | insertion | Frame_Shift_Ins | novel | c.1005_1006insAGAA | p.Glu336ArgfsTer34 | p.E336Rfs*34 | Q8WZA9 | protein_coding | TCGA-A8-A09A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
IRGQ | insertion | Frame_Shift_Ins | novel | c.1799_1800insTTCTTCATGCCGACAA | p.Leu601SerfsTer12 | p.L601Sfs*12 | Q8WZA9 | protein_coding | TCGA-A8-A0AD-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
IRGQ | insertion | Frame_Shift_Ins | rs779595401 | c.876_877insAGCTCTGCTG | p.His293SerfsTer21 | p.H293Sfs*21 | Q8WZA9 | protein_coding | TCGA-BH-A0BR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
IRGQ | insertion | Frame_Shift_Ins | rs779595401 | c.876_877insAGCTCTGCTG | p.His293SerfsTer21 | p.H293Sfs*21 | Q8WZA9 | protein_coding | TCGA-BH-A0BV-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | SD | ||
IRGQ | insertion | Frame_Shift_Ins | novel | c.876_877insGCTG | p.His293AlafsTer19 | p.H293Afs*19 | Q8WZA9 | protein_coding | TCGA-BH-A0HW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | ||
IRGQ | insertion | Frame_Shift_Ins | rs779595401 | c.876_877insAGCTCTGCTG | p.His293SerfsTer21 | p.H293Sfs*21 | Q8WZA9 | protein_coding | TCGA-BH-A1FD-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
IRGQ | SNV | Missense_Mutation | rs150440122 | c.1147G>A | p.Gly383Arg | p.G383R | Q8WZA9 | protein_coding | deleterious(0.05) | benign(0.248) | TCGA-C5-A7CH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unspecific | SD | |
IRGQ | SNV | Missense_Mutation | novel | c.466N>C | p.Asp156His | p.D156H | Q8WZA9 | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.757) | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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