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Gene: GTF2IRD2 |
Gene summary for GTF2IRD2 |
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Gene information | Species | Human | Gene symbol | GTF2IRD2 | Gene ID | 84163 |
Gene name | GTF2I repeat domain containing 2 | |
Gene Alias | FP630 | |
Cytomap | 7q11.23 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q86UP8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84163 | GTF2IRD2 | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.34e-03 | 6.12e-01 | 0.0216 |
84163 | GTF2IRD2 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.10e-08 | 6.24e-01 | -0.1088 |
84163 | GTF2IRD2 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.33e-27 | 8.27e-01 | -0.1954 |
84163 | GTF2IRD2 | HTA11_411_2000001011 | Human | Colorectum | SER | 3.22e-04 | 8.38e-01 | -0.2602 |
84163 | GTF2IRD2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.37e-04 | 4.54e-01 | -0.1207 |
84163 | GTF2IRD2 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.34e-06 | 5.86e-01 | -0.1526 |
84163 | GTF2IRD2 | HTA11_696_2000001011 | Human | Colorectum | AD | 8.53e-21 | 7.28e-01 | -0.1464 |
84163 | GTF2IRD2 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.68e-21 | 7.58e-01 | -0.1001 |
84163 | GTF2IRD2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.82e-12 | 6.87e-01 | -0.059 |
84163 | GTF2IRD2 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.28e-16 | 1.13e+00 | -0.0842 |
84163 | GTF2IRD2 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.15e-07 | 4.59e-01 | 0.096 |
84163 | GTF2IRD2 | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.72e-06 | 7.62e-01 | 0.0446 |
84163 | GTF2IRD2 | HTA11_9408_2000001011 | Human | Colorectum | AD | 1.93e-02 | 7.49e-01 | 0.0451 |
84163 | GTF2IRD2 | HTA11_7663_2000001011 | Human | Colorectum | SER | 3.11e-06 | 7.34e-01 | 0.0131 |
84163 | GTF2IRD2 | HTA11_10623_2000001011 | Human | Colorectum | AD | 4.61e-03 | 5.06e-01 | -0.0177 |
84163 | GTF2IRD2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.95e-18 | 7.42e-01 | 0.0338 |
84163 | GTF2IRD2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 8.15e-16 | 6.84e-01 | 0.0674 |
84163 | GTF2IRD2 | HTA11_6818_2000001011 | Human | Colorectum | AD | 2.85e-09 | 9.48e-01 | 0.0112 |
84163 | GTF2IRD2 | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.25e-06 | 5.32e-01 | 0.0588 |
84163 | GTF2IRD2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.20e-03 | 2.57e-01 | 0.294 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Liver | Cyst | ![]() |
Lung | IAC | ![]() |
Lung | AIS | ![]() |
Lung | AAH | ![]() |
Lung | MIAC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GTF2IRD2 | SNV | Missense_Mutation | novel | c.50N>T | p.Ser17Leu | p.S17L | protein_coding | deleterious_low_confidence(0) | benign(0.236) | TCGA-AC-A5XS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD | |
GTF2IRD2 | SNV | Missense_Mutation | novel | c.557N>T | p.Pro186Leu | p.P186L | protein_coding | tolerated_low_confidence(0.07) | possibly_damaging(0.691) | TCGA-AC-A8OS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GTF2IRD2 | SNV | Missense_Mutation | novel | c.641A>G | p.Asn214Ser | p.N214S | protein_coding | tolerated_low_confidence(1) | benign(0) | TCGA-AN-A0XP-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
GTF2IRD2 | SNV | Missense_Mutation | novel | c.2462N>C | p.Asn821Thr | p.N821T | protein_coding | tolerated(0.19) | benign(0.138) | TCGA-B6-A0IH-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
GTF2IRD2 | SNV | Missense_Mutation | novel | c.1255N>T | p.Arg419Cys | p.R419C | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GTF2IRD2 | SNV | Missense_Mutation | novel | c.2537N>C | p.Glu846Ala | p.E846A | protein_coding | tolerated(0.1) | possibly_damaging(0.579) | TCGA-C8-A12L-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GTF2IRD2 | SNV | Missense_Mutation | novel | c.1567G>A | p.Val523Met | p.V523M | protein_coding | tolerated(0.12) | benign(0.053) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
GTF2IRD2 | SNV | Missense_Mutation | novel | c.2638N>G | p.Thr880Ala | p.T880A | protein_coding | tolerated(0.83) | benign(0.003) | TCGA-E9-A22E-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphane | SD | |
GTF2IRD2 | SNV | Missense_Mutation | novel | c.635C>T | p.Pro212Leu | p.P212L | protein_coding | deleterious_low_confidence(0.01) | benign(0.007) | TCGA-V7-A7HQ-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | letrozole | CR | |
GTF2IRD2 | SNV | Missense_Mutation | novel | c.2272N>A | p.Asp758Asn | p.D758N | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-EK-A3GJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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