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Gene: GDI2 |
Gene summary for GDI2 |
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Gene information | Species | Human | Gene symbol | GDI2 | Gene ID | 2665 |
Gene name | GDP dissociation inhibitor 2 | |
Gene Alias | HEL-S-46e | |
Cytomap | 10p15.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | P50395 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2665 | GDI2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.97e-06 | -3.59e-01 | 0.0155 |
2665 | GDI2 | HTA11_78_2000001011 | Human | Colorectum | AD | 9.83e-03 | 4.66e-01 | -0.1088 |
2665 | GDI2 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.13e-03 | 3.61e-01 | -0.1954 |
2665 | GDI2 | HTA11_83_2000001011 | Human | Colorectum | SER | 9.69e-03 | 5.20e-01 | -0.1526 |
2665 | GDI2 | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.71e-02 | 7.00e-01 | 0.0171 |
2665 | GDI2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 5.67e-14 | 1.03e+00 | 0.294 |
2665 | GDI2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.54e-05 | 6.21e-01 | 0.3859 |
2665 | GDI2 | F007 | Human | Colorectum | FAP | 4.33e-02 | -2.52e-01 | 0.1176 |
2665 | GDI2 | A015-C-203 | Human | Colorectum | FAP | 2.82e-23 | -3.24e-01 | -0.1294 |
2665 | GDI2 | A015-C-204 | Human | Colorectum | FAP | 5.83e-03 | -1.45e-01 | -0.0228 |
2665 | GDI2 | A014-C-040 | Human | Colorectum | FAP | 1.34e-02 | -2.20e-01 | -0.1184 |
2665 | GDI2 | A002-C-201 | Human | Colorectum | FAP | 5.51e-10 | -2.42e-01 | 0.0324 |
2665 | GDI2 | A002-C-203 | Human | Colorectum | FAP | 5.73e-04 | -1.04e-01 | 0.2786 |
2665 | GDI2 | A001-C-119 | Human | Colorectum | FAP | 3.50e-05 | -2.65e-01 | -0.1557 |
2665 | GDI2 | A001-C-108 | Human | Colorectum | FAP | 2.35e-13 | -1.75e-01 | -0.0272 |
2665 | GDI2 | A002-C-205 | Human | Colorectum | FAP | 1.57e-17 | -3.13e-01 | -0.1236 |
2665 | GDI2 | A001-C-104 | Human | Colorectum | FAP | 2.34e-04 | -6.31e-02 | 0.0184 |
2665 | GDI2 | A015-C-005 | Human | Colorectum | FAP | 1.45e-03 | -2.00e-01 | -0.0336 |
2665 | GDI2 | A015-C-006 | Human | Colorectum | FAP | 1.60e-11 | -2.50e-01 | -0.0994 |
2665 | GDI2 | A015-C-106 | Human | Colorectum | FAP | 9.16e-11 | -2.39e-01 | -0.0511 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Liver | Cyst | ![]() |
Lung | IAC | ![]() |
Lung | AIS | ![]() |
Lung | AAH | ![]() |
Lung | MIAC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GDI2 | SNV | Missense_Mutation | novel | c.293G>A | p.Arg98His | p.R98H | P50395 | protein_coding | deleterious(0.02) | benign(0.168) | TCGA-AC-A3TN-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
GDI2 | SNV | Missense_Mutation | rs533312902 | c.868N>T | p.Arg290Trp | p.R290W | P50395 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GDI2 | deletion | Frame_Shift_Del | novel | c.135delT | p.Ile46Ter | p.I46* | P50395 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
GDI2 | SNV | Missense_Mutation | novel | c.427N>C | p.Phe143Leu | p.F143L | P50395 | protein_coding | tolerated(0.1) | benign(0.296) | TCGA-VS-A8EJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
GDI2 | SNV | Missense_Mutation | novel | c.1243N>A | p.Asp415Asn | p.D415N | P50395 | protein_coding | tolerated(0.29) | benign(0.001) | TCGA-ZJ-AAXA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
GDI2 | deletion | Frame_Shift_Del | novel | c.52delN | p.Ile18SerfsTer5 | p.I18Sfs*5 | P50395 | protein_coding | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | ||
GDI2 | SNV | Missense_Mutation | c.31N>T | p.Gly11Cys | p.G11C | P50395 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GDI2 | SNV | Missense_Mutation | c.890N>C | p.Val297Ala | p.V297A | P50395 | protein_coding | deleterious(0.02) | possibly_damaging(0.715) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
GDI2 | SNV | Missense_Mutation | c.107A>G | p.Asn36Ser | p.N36S | P50395 | protein_coding | deleterious(0.01) | possibly_damaging(0.538) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
GDI2 | SNV | Missense_Mutation | novel | c.865G>T | p.Asp289Tyr | p.D289Y | P50395 | protein_coding | deleterious(0) | possibly_damaging(0.855) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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