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Gene: EXOC3L2 |
Gene summary for EXOC3L2 |
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Gene information | Species | Human | Gene symbol | EXOC3L2 | Gene ID | 90332 |
Gene name | exocyst complex component 3 like 2 | |
Gene Alias | XTP7 | |
Cytomap | 19q13.32 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
90332 | EXOC3L2 | HCC1 | Human | Liver | HCC | 3.43e-04 | 1.80e+00 | 0.5336 |
90332 | EXOC3L2 | HCC2 | Human | Liver | HCC | 1.37e-08 | 7.58e-01 | 0.5341 |
90332 | EXOC3L2 | HCC5 | Human | Liver | HCC | 1.26e-02 | 4.07e-01 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Liver | Cyst | ![]() |
Lung | IAC | ![]() |
Lung | AIS | ![]() |
Lung | AAH | ![]() |
Lung | MIAC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00315031 | Liver | HCC | protein-containing complex localization | 129/7958 | 220/18723 | 9.38e-07 | 1.42e-05 | 129 |
GO:0034629 | Liver | HCC | cellular protein-containing complex localization | 17/7958 | 22/18723 | 9.84e-04 | 5.70e-03 | 17 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EXOC3L2 | deletion | Frame_Shift_Del | novel | c.109delN | p.Leu37PhefsTer53 | p.L37Ffs*53 | Q2M3D2 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
EXOC3L2 | SNV | Missense_Mutation | c.1039N>A | p.Glu347Lys | p.E347K | Q2M3D2 | protein_coding | deleterious(0.04) | benign(0.315) | TCGA-EK-A2RC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
EXOC3L2 | SNV | Missense_Mutation | novel | c.443G>C | p.Arg148Thr | p.R148T | protein_coding | deleterious(0.01) | benign(0.412) | TCGA-MA-AA41-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
EXOC3L2 | SNV | Missense_Mutation | novel | c.244G>A | p.Asp82Asn | p.D82N | protein_coding | tolerated(0.43) | possibly_damaging(0.737) | TCGA-UC-A7PG-06 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | PD | |
EXOC3L2 | SNV | Missense_Mutation | rs756258972 | c.967N>A | p.Asp323Asn | p.D323N | Q2M3D2 | protein_coding | tolerated(0.48) | benign(0.32) | TCGA-VS-A9UD-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR |
EXOC3L2 | SNV | Missense_Mutation | novel | c.608N>A | p.Gly203Asp | p.G203D | Q2M3D2 | protein_coding | tolerated(0.1) | benign(0.197) | TCGA-VS-A9UJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
EXOC3L2 | SNV | Missense_Mutation | c.1039G>A | p.Glu347Lys | p.E347K | Q2M3D2 | protein_coding | deleterious(0.04) | benign(0.315) | TCGA-VS-A9UL-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD | |
EXOC3L2 | SNV | Missense_Mutation | rs139655836 | c.305N>A | p.Arg102His | p.R102H | Q2M3D2 | protein_coding | deleterious(0.01) | probably_damaging(0.973) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
EXOC3L2 | SNV | Missense_Mutation | rs749294188 | c.1100N>A | p.Arg367His | p.R367H | Q2M3D2 | protein_coding | tolerated(0.08) | benign(0.011) | TCGA-AA-3521-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
EXOC3L2 | SNV | Missense_Mutation | c.425C>T | p.Ala142Val | p.A142V | Q2M3D2 | protein_coding | tolerated(0.12) | probably_damaging(0.933) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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