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Gene: ENHO |
Gene summary for ENHO |
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Gene information | Species | Human | Gene symbol | ENHO | Gene ID | 375704 |
Gene name | energy homeostasis associated | |
Gene Alias | C9orf165 | |
Cytomap | 9p13.3 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | Q6UWT2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
375704 | ENHO | HCC1_Meng | Human | Liver | HCC | 2.16e-35 | 1.52e-01 | 0.0246 |
375704 | ENHO | HCC1 | Human | Liver | HCC | 8.27e-05 | 1.84e+00 | 0.5336 |
375704 | ENHO | HCC2 | Human | Liver | HCC | 9.74e-22 | 3.20e+00 | 0.5341 |
375704 | ENHO | S028 | Human | Liver | HCC | 6.32e-03 | 1.37e-01 | 0.2503 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Liver | Cyst | ![]() |
Lung | IAC | ![]() |
Lung | AIS | ![]() |
Lung | AAH | ![]() |
Lung | MIAC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ENHO | SNV | Missense_Mutation | rs578062288 | c.136G>A | p.Glu46Lys | p.E46K | Q6UWT2 | protein_coding | tolerated_low_confidence(0.19) | benign(0.018) | TCGA-IR-A3LF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ENHO | SNV | Missense_Mutation | c.91T>A | p.Cys31Ser | p.C31S | Q6UWT2 | protein_coding | deleterious_low_confidence(0) | benign(0.003) | TCGA-Q1-A6DT-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
ENHO | SNV | Missense_Mutation | rs752947654 | c.149N>G | p.Asn50Ser | p.N50S | Q6UWT2 | protein_coding | deleterious_low_confidence(0.04) | possibly_damaging(0.866) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ENHO | SNV | Missense_Mutation | c.34G>A | p.Ala12Thr | p.A12T | Q6UWT2 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.983) | TCGA-G4-6306-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ENHO | SNV | Missense_Mutation | c.140N>A | p.Ser47Tyr | p.S47Y | Q6UWT2 | protein_coding | deleterious_low_confidence(0) | benign(0.063) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ENHO | SNV | Missense_Mutation | c.40N>A | p.Val14Ile | p.V14I | Q6UWT2 | protein_coding | tolerated_low_confidence(0.34) | benign(0.101) | TCGA-BG-A0M3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ENHO | SNV | Missense_Mutation | novel | c.47A>G | p.Asn16Ser | p.N16S | Q6UWT2 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.931) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ENHO | insertion | Frame_Shift_Ins | novel | c.135_136insCT | p.Glu46LeufsTer44 | p.E46Lfs*44 | Q6UWT2 | protein_coding | TCGA-D1-A176-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ENHO | SNV | Missense_Mutation | c.211A>G | p.Ser71Gly | p.S71G | Q6UWT2 | protein_coding | deleterious_low_confidence(0) | benign(0.182) | TCGA-05-4410-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ENHO | SNV | Missense_Mutation | novel | c.79N>C | p.Trp27Arg | p.W27R | Q6UWT2 | protein_coding | deleterious_low_confidence(0) | benign(0.266) | TCGA-DQ-5629-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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