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Gene: CYS1 |
Gene summary for CYS1 |
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Gene information | Species | Human | Gene symbol | CYS1 | Gene ID | 192668 |
Gene name | cystin 1 | |
Gene Alias | CYS1 | |
Cytomap | 2p25.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q717R9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
192668 | CYS1 | PTC04 | Human | Thyroid | PTC | 9.62e-06 | 1.63e-01 | 0.1927 |
192668 | CYS1 | PTC07 | Human | Thyroid | PTC | 2.96e-92 | 1.62e+00 | 0.2044 |
192668 | CYS1 | ATC13 | Human | Thyroid | ATC | 8.50e-12 | 2.48e-01 | 0.34 |
192668 | CYS1 | ATC5 | Human | Thyroid | ATC | 3.77e-15 | 2.72e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Liver | Cyst | ![]() |
Lung | IAC | ![]() |
Lung | AIS | ![]() |
Lung | AAH | ![]() |
Lung | MIAC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CYS1 | SNV | Missense_Mutation | rs780173331 | c.407N>T | p.Pro136Leu | p.P136L | Q717R9 | protein_coding | tolerated(0.12) | benign(0.247) | TCGA-F4-6461-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
CYS1 | SNV | Missense_Mutation | rs780173331 | c.407N>T | p.Pro136Leu | p.P136L | Q717R9 | protein_coding | tolerated(0.12) | benign(0.247) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CYS1 | SNV | Missense_Mutation | novel | c.376C>A | p.Pro126Thr | p.P126T | Q717R9 | protein_coding | deleterious(0.01) | probably_damaging(0.986) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
CYS1 | SNV | Missense_Mutation | novel | c.359G>A | p.Gly120Asp | p.G120D | Q717R9 | protein_coding | tolerated(0.12) | benign(0.297) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
CYS1 | SNV | Missense_Mutation | novel | c.431N>T | p.Ser144Leu | p.S144L | Q717R9 | protein_coding | tolerated(0.05) | benign(0.232) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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