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Gene: CHST13 |
Gene summary for CHST13 |
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Gene information | Species | Human | Gene symbol | CHST13 | Gene ID | 166012 |
Gene name | carbohydrate sulfotransferase 13 | |
Gene Alias | C4ST3 | |
Cytomap | 3q21.3 | |
Gene Type | protein-coding | GO ID | GO:0005975 | UniProtAcc | Q8NET6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
166012 | CHST13 | HCC1_Meng | Human | Liver | HCC | 3.11e-81 | 4.58e-01 | 0.0246 |
166012 | CHST13 | HCC2 | Human | Liver | HCC | 5.43e-16 | 2.88e+00 | 0.5341 |
166012 | CHST13 | Pt14.a | Human | Liver | HCC | 3.81e-10 | 5.18e-01 | 0.0169 |
166012 | CHST13 | S014 | Human | Liver | HCC | 1.44e-49 | 2.17e+00 | 0.2254 |
166012 | CHST13 | S015 | Human | Liver | HCC | 9.93e-51 | 2.56e+00 | 0.2375 |
166012 | CHST13 | S016 | Human | Liver | HCC | 3.69e-63 | 2.34e+00 | 0.2243 |
166012 | CHST13 | S027 | Human | Liver | HCC | 1.25e-04 | 3.76e-01 | 0.2446 |
166012 | CHST13 | S028 | Human | Liver | HCC | 1.52e-20 | 8.09e-01 | 0.2503 |
166012 | CHST13 | S029 | Human | Liver | HCC | 5.47e-18 | 6.63e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Liver | Cyst | ![]() |
Lung | IAC | ![]() |
Lung | AIS | ![]() |
Lung | AAH | ![]() |
Lung | MIAC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000679021 | Liver | HCC | sulfur compound metabolic process | 212/7958 | 339/18723 | 5.60e-14 | 3.39e-12 | 212 |
GO:00442722 | Liver | HCC | sulfur compound biosynthetic process | 95/7958 | 148/18723 | 7.89e-08 | 1.58e-06 | 95 |
GO:00160512 | Liver | HCC | carbohydrate biosynthetic process | 113/7958 | 202/18723 | 7.64e-05 | 6.83e-04 | 113 |
GO:0009100 | Liver | HCC | glycoprotein metabolic process | 193/7958 | 387/18723 | 1.89e-03 | 9.62e-03 | 193 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CHST13 | SNV | Missense_Mutation | rs779854156 | c.914N>T | p.Ala305Val | p.A305V | Q8NET6 | protein_coding | deleterious(0.03) | possibly_damaging(0.768) | TCGA-A7-A56D-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
CHST13 | SNV | Missense_Mutation | novel | c.295G>A | p.Val99Met | p.V99M | Q8NET6 | protein_coding | deleterious(0.02) | possibly_damaging(0.895) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CHST13 | SNV | Missense_Mutation | rs779854156 | c.914N>T | p.Ala305Val | p.A305V | Q8NET6 | protein_coding | deleterious(0.03) | possibly_damaging(0.768) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CHST13 | SNV | Missense_Mutation | novel | c.286C>A | p.Leu96Met | p.L96M | Q8NET6 | protein_coding | deleterious(0.04) | probably_damaging(0.996) | TCGA-VS-A9V0-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
CHST13 | SNV | Missense_Mutation | c.932N>C | p.Ile311Thr | p.I311T | Q8NET6 | protein_coding | deleterious(0) | probably_damaging(0.955) | TCGA-AA-3502-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CHST13 | SNV | Missense_Mutation | c.904N>A | p.Asp302Asn | p.D302N | Q8NET6 | protein_coding | tolerated(0.19) | benign(0.022) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CHST13 | SNV | Missense_Mutation | c.169G>T | p.Asp57Tyr | p.D57Y | Q8NET6 | protein_coding | deleterious(0) | possibly_damaging(0.847) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
CHST13 | SNV | Missense_Mutation | c.370N>A | p.Leu124Met | p.L124M | Q8NET6 | protein_coding | tolerated(0.64) | benign(0.17) | TCGA-F4-6809-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
CHST13 | SNV | Missense_Mutation | novel | c.371N>G | p.Leu124Arg | p.L124R | Q8NET6 | protein_coding | deleterious(0) | probably_damaging(0.936) | TCGA-F4-6809-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
CHST13 | SNV | Missense_Mutation | c.569N>T | p.Arg190Leu | p.R190L | Q8NET6 | protein_coding | tolerated(0.23) | benign(0.156) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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