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Gene: CFAP70 |
Gene summary for CFAP70 |
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Gene information | Species | Human | Gene symbol | CFAP70 | Gene ID | 118491 |
Gene name | cilia and flagella associated protein 70 | |
Gene Alias | SPGF41 | |
Cytomap | 10q22.2 | |
Gene Type | protein-coding | GO ID | GO:0003341 | UniProtAcc | Q5T0N1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
118491 | CFAP70 | NAFLD1 | Human | Liver | NAFLD | 2.35e-06 | 5.76e-01 | -0.04 |
118491 | CFAP70 | HCC1_Meng | Human | Liver | HCC | 8.60e-06 | -8.72e-03 | 0.0246 |
118491 | CFAP70 | HCC2 | Human | Liver | HCC | 1.37e-04 | 2.55e+00 | 0.5341 |
118491 | CFAP70 | HTA12-15-2 | Human | Pancreas | PDAC | 4.32e-07 | 4.38e-01 | 0.2315 |
118491 | CFAP70 | HTA12-23-1 | Human | Pancreas | PDAC | 1.44e-05 | 5.65e-01 | 0.3405 |
118491 | CFAP70 | HTA12-26-1 | Human | Pancreas | PDAC | 9.79e-17 | 7.08e-01 | 0.3728 |
118491 | CFAP70 | HTA12-29-1 | Human | Pancreas | PDAC | 1.17e-22 | 5.24e-01 | 0.3722 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Liver | Cyst | ![]() |
Lung | IAC | ![]() |
Lung | AIS | ![]() |
Lung | AAH | ![]() |
Lung | MIAC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CFAP70 | SNV | Missense_Mutation | c.1294C>G | p.Gln432Glu | p.Q432E | Q5T0N1 | protein_coding | tolerated(0.58) | benign(0.005) | TCGA-A7-A0DA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
CFAP70 | SNV | Missense_Mutation | c.106G>A | p.Glu36Lys | p.E36K | Q5T0N1 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-A8-A09G-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
CFAP70 | SNV | Missense_Mutation | novel | c.3256N>A | p.Ala1086Thr | p.A1086T | Q5T0N1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CFAP70 | SNV | Missense_Mutation | c.2821N>G | p.Leu941Val | p.L941V | Q5T0N1 | protein_coding | deleterious(0.04) | possibly_damaging(0.66) | TCGA-C8-A274-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
CFAP70 | SNV | Missense_Mutation | c.10G>C | p.Val4Leu | p.V4L | Q5T0N1 | protein_coding | tolerated_low_confidence(0.34) | benign(0.005) | TCGA-D8-A143-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
CFAP70 | insertion | Frame_Shift_Ins | novel | c.2284_2285insTTAAAAAATGT | p.Glu762ValfsTer19 | p.E762Vfs*19 | Q5T0N1 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
CFAP70 | SNV | Missense_Mutation | novel | c.3196A>G | p.Asn1066Asp | p.N1066D | Q5T0N1 | protein_coding | tolerated(0.23) | benign(0.109) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CFAP70 | SNV | Missense_Mutation | novel | c.1057G>T | p.Gly353Cys | p.G353C | Q5T0N1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CFAP70 | SNV | Missense_Mutation | novel | c.279A>C | p.Glu93Asp | p.E93D | Q5T0N1 | protein_coding | tolerated(0.13) | possibly_damaging(0.73) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CFAP70 | SNV | Missense_Mutation | novel | c.310N>G | p.Leu104Val | p.L104V | Q5T0N1 | protein_coding | deleterious(0) | probably_damaging(0.95) | TCGA-EK-A2RA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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