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Gene: ARL14 |
Gene summary for ARL14 |
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Gene information | Species | Human | Gene symbol | ARL14 | Gene ID | 80117 |
Gene name | ADP ribosylation factor like GTPase 14 | |
Gene Alias | ARF7 | |
Cytomap | 3q25.33 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q8N4G2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80117 | ARL14 | LZE8T | Human | Esophagus | ESCC | 3.19e-08 | 3.47e-01 | 0.067 |
80117 | ARL14 | P8T-E | Human | Esophagus | ESCC | 3.52e-19 | 5.13e-01 | 0.0889 |
80117 | ARL14 | P9T-E | Human | Esophagus | ESCC | 1.99e-10 | 2.47e-01 | 0.1131 |
80117 | ARL14 | P12T-E | Human | Esophagus | ESCC | 2.39e-24 | 4.36e-01 | 0.1122 |
80117 | ARL14 | P15T-E | Human | Esophagus | ESCC | 4.24e-17 | 3.31e-01 | 0.1149 |
80117 | ARL14 | P16T-E | Human | Esophagus | ESCC | 4.16e-22 | 4.45e-01 | 0.1153 |
80117 | ARL14 | P20T-E | Human | Esophagus | ESCC | 6.49e-19 | 3.74e-01 | 0.1124 |
80117 | ARL14 | P26T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.46e-01 | 0.1276 |
80117 | ARL14 | P37T-E | Human | Esophagus | ESCC | 5.94e-11 | 3.61e-01 | 0.1371 |
80117 | ARL14 | P39T-E | Human | Esophagus | ESCC | 3.60e-13 | 2.50e-01 | 0.0894 |
80117 | ARL14 | P47T-E | Human | Esophagus | ESCC | 1.96e-05 | 1.79e-01 | 0.1067 |
80117 | ARL14 | P52T-E | Human | Esophagus | ESCC | 8.84e-05 | 2.35e-01 | 0.1555 |
80117 | ARL14 | P56T-E | Human | Esophagus | ESCC | 1.16e-08 | 5.67e-01 | 0.1613 |
80117 | ARL14 | P62T-E | Human | Esophagus | ESCC | 1.20e-04 | 1.55e-01 | 0.1302 |
80117 | ARL14 | P65T-E | Human | Esophagus | ESCC | 3.37e-05 | 2.22e-01 | 0.0978 |
80117 | ARL14 | P74T-E | Human | Esophagus | ESCC | 3.23e-09 | 3.31e-01 | 0.1479 |
80117 | ARL14 | P75T-E | Human | Esophagus | ESCC | 7.90e-03 | 1.30e-01 | 0.1125 |
80117 | ARL14 | P76T-E | Human | Esophagus | ESCC | 3.75e-03 | 8.70e-02 | 0.1207 |
80117 | ARL14 | P82T-E | Human | Esophagus | ESCC | 9.44e-05 | 4.04e-01 | 0.1072 |
80117 | ARL14 | P89T-E | Human | Esophagus | ESCC | 6.10e-11 | 5.24e-01 | 0.1752 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Liver | Cyst | ![]() |
Lung | IAC | ![]() |
Lung | AIS | ![]() |
Lung | AAH | ![]() |
Lung | MIAC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARL14 | SNV | Missense_Mutation | rs772796463 | c.392N>C | p.Leu131Pro | p.L131P | Q8N4G2 | protein_coding | deleterious(0) | possibly_damaging(0.876) | TCGA-A8-A08C-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | CR |
ARL14 | SNV | Missense_Mutation | c.567N>G | p.Phe189Leu | p.F189L | Q8N4G2 | protein_coding | tolerated_low_confidence(0.06) | benign(0.005) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR | |
ARL14 | SNV | Missense_Mutation | rs762555229 | c.229N>C | p.Cys77Arg | p.C77R | Q8N4G2 | protein_coding | deleterious(0.02) | benign(0.038) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARL14 | SNV | Missense_Mutation | c.210N>C | p.Lys70Asn | p.K70N | Q8N4G2 | protein_coding | deleterious(0.01) | benign(0.231) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ARL14 | SNV | Missense_Mutation | c.133N>T | p.Ile45Leu | p.I45L | Q8N4G2 | protein_coding | deleterious(0.02) | benign(0.273) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ARL14 | SNV | Missense_Mutation | c.355N>A | p.Val119Ile | p.V119I | Q8N4G2 | protein_coding | tolerated(0.19) | benign(0.044) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ARL14 | SNV | Missense_Mutation | rs17853289 | c.172C>T | p.Leu58Phe | p.L58F | Q8N4G2 | protein_coding | tolerated(0.3) | benign(0.012) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
ARL14 | SNV | Missense_Mutation | novel | c.117N>G | p.Ile39Met | p.I39M | Q8N4G2 | protein_coding | deleterious(0) | benign(0.185) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARL14 | SNV | Missense_Mutation | c.277N>T | p.Asp93Tyr | p.D93Y | Q8N4G2 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ARL14 | SNV | Missense_Mutation | rs754095868 | c.26C>T | p.Pro9Leu | p.P9L | Q8N4G2 | protein_coding | tolerated(0.75) | benign(0.001) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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