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Gene: ANKUB1 |
Gene summary for ANKUB1 |
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Gene information | Species | Human | Gene symbol | ANKUB1 | Gene ID | 389161 |
Gene name | ankyrin repeat and ubiquitin domain containing 1 | |
Gene Alias | C3orf16 | |
Cytomap | 3q25.1 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | A6NFN9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
389161 | ANKUB1 | CCI_1 | Human | Cervix | CC | 3.15e-09 | 6.19e-01 | 0.528 |
389161 | ANKUB1 | CCI_2 | Human | Cervix | CC | 5.49e-27 | 1.77e+00 | 0.5249 |
389161 | ANKUB1 | CCI_3 | Human | Cervix | CC | 4.56e-16 | 7.80e-01 | 0.516 |
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Tissue | Expression Dynamics | Abbreviation |
Cervix | ![]() | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
N_HPV: HPV-infected normal cervix |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Liver | Cyst | ![]() |
Lung | IAC | ![]() |
Lung | AIS | ![]() |
Lung | AAH | ![]() |
Lung | MIAC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ANKUB1 | SNV | Missense_Mutation | novel | c.482N>C | p.Gly161Ala | p.G161A | A6NFN9 | protein_coding | deleterious(0.01) | possibly_damaging(0.826) | TCGA-C5-A8XK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
ANKUB1 | SNV | Missense_Mutation | rs774131451 | c.647N>T | p.Ala216Val | p.A216V | A6NFN9 | protein_coding | tolerated(1) | benign(0.001) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ANKUB1 | SNV | Missense_Mutation | novel | c.1135T>C | p.Ser379Pro | p.S379P | A6NFN9 | protein_coding | tolerated(1) | benign(0) | TCGA-LP-A4AW-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ANKUB1 | SNV | Missense_Mutation | novel | c.1616N>G | p.Ser539Cys | p.S539C | protein_coding | tolerated_low_confidence(0.17) | benign(0.103) | TCGA-VS-A9UH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ANKUB1 | SNV | Missense_Mutation | c.1136N>A | p.Ser379Tyr | p.S379Y | A6NFN9 | protein_coding | tolerated(0.32) | benign(0.275) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD | |
ANKUB1 | SNV | Missense_Mutation | c.1026A>C | p.Lys342Asn | p.K342N | A6NFN9 | protein_coding | deleterious(0.05) | benign(0.112) | TCGA-AA-3511-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
ANKUB1 | SNV | Missense_Mutation | c.1336N>A | p.Leu446Ile | p.L446I | A6NFN9 | protein_coding | tolerated(0.06) | benign(0.1) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ANKUB1 | SNV | Missense_Mutation | rs757464210 | c.752N>A | p.Gly251Asp | p.G251D | A6NFN9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ANKUB1 | SNV | Missense_Mutation | novel | c.1504N>G | p.Arg502Gly | p.R502G | A6NFN9 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.795) | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ANKUB1 | SNV | Missense_Mutation | c.90N>T | p.Lys30Asn | p.K30N | A6NFN9 | protein_coding | deleterious(0.04) | benign(0.116) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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