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Gene: ANKRD44 |
Gene summary for ANKRD44 |
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Gene information | Species | Human | Gene symbol | ANKRD44 | Gene ID | 91526 |
Gene name | ankyrin repeat domain 44 | |
Gene Alias | PP6-ARS-B | |
Cytomap | 2q33.1 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q8N8A2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
91526 | ANKRD44 | TD9 | Human | Lung | IAC | 2.15e-04 | 6.46e-01 | 0.088 |
91526 | ANKRD44 | RNA-P10T2-P10T2-1 | Human | Lung | AAH | 9.51e-04 | 8.76e-01 | -0.1271 |
91526 | ANKRD44 | RNA-P10T2-P10T2-2 | Human | Lung | AAH | 1.34e-04 | 7.28e-01 | -0.1406 |
91526 | ANKRD44 | RNA-P10T2-P10T2-3 | Human | Lung | AAH | 7.73e-04 | 7.34e-01 | -0.1408 |
91526 | ANKRD44 | RNA-P10T2-P10T2-4 | Human | Lung | AAH | 3.16e-05 | 7.60e-01 | -0.138 |
91526 | ANKRD44 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 1.46e-21 | 9.29e-01 | -0.2116 |
91526 | ANKRD44 | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 8.74e-09 | 9.18e-01 | -0.1941 |
91526 | ANKRD44 | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 4.63e-11 | 9.06e-01 | -0.2107 |
91526 | ANKRD44 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 1.77e-14 | 8.25e-01 | -0.2119 |
91526 | ANKRD44 | RNA-P6T1-P6T1-1 | Human | Lung | MIAC | 3.40e-04 | 9.48e-01 | -0.0238 |
91526 | ANKRD44 | RNA-P6T1-P6T1-4 | Human | Lung | MIAC | 1.24e-04 | 7.43e-01 | -0.0263 |
91526 | ANKRD44 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 2.63e-26 | 8.34e-01 | -0.0166 |
91526 | ANKRD44 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 3.02e-22 | 7.29e-01 | -0.0132 |
91526 | ANKRD44 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 2.18e-28 | 7.71e-01 | -0.013 |
91526 | ANKRD44 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 2.88e-24 | 8.05e-01 | -0.0121 |
91526 | ANKRD44 | RNA-P7T1-P7T1-1 | Human | Lung | AIS | 1.51e-05 | 6.28e-01 | -0.0961 |
91526 | ANKRD44 | RNA-P7T1-P7T1-3 | Human | Lung | AIS | 5.89e-03 | 5.17e-01 | -0.0822 |
91526 | ANKRD44 | RNA-P7T1-P7T1-4 | Human | Lung | AIS | 4.28e-06 | 6.35e-01 | -0.0809 |
91526 | ANKRD44 | HTA12-15-2 | Human | Pancreas | PDAC | 4.09e-08 | 4.76e-01 | 0.2315 |
91526 | ANKRD44 | HTA12-16-5 | Human | Pancreas | PDAC | 7.74e-05 | 4.46e-01 | 0.047 |
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Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Liver | Cyst | ![]() |
Lung | IAC | ![]() |
Lung | AIS | ![]() |
Lung | AAH | ![]() |
Lung | MIAC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ANKRD44 | SNV | Missense_Mutation | c.290N>T | p.Ser97Leu | p.S97L | protein_coding | deleterious(0.01) | possibly_damaging(0.83) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
ANKRD44 | SNV | Missense_Mutation | novel | c.2274N>T | p.Met758Ile | p.M758I | protein_coding | tolerated(0.31) | benign(0) | TCGA-BH-A0E2-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
ANKRD44 | SNV | Missense_Mutation | c.842N>T | p.Ala281Val | p.A281V | protein_coding | tolerated(0.48) | benign(0.163) | TCGA-C8-A1HO-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR | ||
ANKRD44 | SNV | Missense_Mutation | c.2504N>C | p.Arg835Thr | p.R835T | protein_coding | tolerated(0.49) | benign(0.014) | TCGA-E9-A243-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | PD | ||
ANKRD44 | SNV | Missense_Mutation | novel | c.904C>G | p.Gln302Glu | p.Q302E | protein_coding | deleterious(0.01) | possibly_damaging(0.844) | TCGA-LD-A7W5-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD | |
ANKRD44 | SNV | Missense_Mutation | novel | c.1077A>G | p.Ile359Met | p.I359M | protein_coding | tolerated(0.55) | possibly_damaging(0.474) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ANKRD44 | SNV | Missense_Mutation | novel | c.376A>G | p.Ile126Val | p.I126V | protein_coding | deleterious(0.04) | possibly_damaging(0.491) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ANKRD44 | SNV | Missense_Mutation | novel | c.460N>A | p.Glu154Lys | p.E154K | protein_coding | deleterious(0.03) | possibly_damaging(0.902) | TCGA-C5-A1M7-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ANKRD44 | SNV | Missense_Mutation | c.1999G>A | p.Asp667Asn | p.D667N | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
ANKRD44 | SNV | Missense_Mutation | c.1043G>A | p.Arg348Lys | p.R348K | protein_coding | tolerated(0.17) | possibly_damaging(0.765) | TCGA-IR-A3LL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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