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Gene: ZNF182 |
Gene summary for ZNF182 |
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Gene information | Species | Human | Gene symbol | ZNF182 | Gene ID | 7569 |
Gene name | zinc finger protein 182 | |
Gene Alias | HHZ150 | |
Cytomap | Xp11.23 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P17025 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7569 | ZNF182 | HCC1_Meng | Human | Liver | HCC | 1.13e-10 | 6.09e-03 | 0.0246 |
7569 | ZNF182 | HCC1 | Human | Liver | HCC | 4.49e-17 | 4.48e+00 | 0.5336 |
7569 | ZNF182 | HCC2 | Human | Liver | HCC | 5.09e-04 | 2.57e+00 | 0.5341 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Stomach | WIM | ![]() |
Stomach | SIM | ![]() |
Liver | NAFLD | ![]() |
Liver | Cirrhotic | ![]() |
Liver | HCC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF182 | SNV | Missense_Mutation | c.861N>C | p.Glu287Asp | p.E287D | P17025 | protein_coding | deleterious(0) | possibly_damaging(0.825) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ZNF182 | insertion | Nonsense_Mutation | novel | c.78_79insTAAGTCG | p.Val27Ter | p.V27* | P17025 | protein_coding | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | ||
ZNF182 | SNV | Missense_Mutation | c.422N>C | p.Gly141Ala | p.G141A | P17025 | protein_coding | tolerated(0.13) | benign(0) | TCGA-C5-A1BJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF182 | SNV | Missense_Mutation | rs782476080 | c.1739G>A | p.Arg580Gln | p.R580Q | P17025 | protein_coding | tolerated(0.3) | possibly_damaging(0.51) | TCGA-HM-A3JJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
ZNF182 | SNV | Missense_Mutation | novel | c.259N>A | p.Glu87Lys | p.E87K | P17025 | protein_coding | tolerated(0.42) | benign(0.142) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF182 | SNV | Missense_Mutation | c.975N>T | p.Lys325Asn | p.K325N | P17025 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-Q1-A73P-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF182 | SNV | Missense_Mutation | novel | c.591N>C | p.Glu197Asp | p.E197D | P17025 | protein_coding | tolerated(0.29) | benign(0.146) | TCGA-Q1-A73P-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF182 | SNV | Missense_Mutation | c.1606N>A | p.His536Asn | p.H536N | P17025 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZNF182 | SNV | Missense_Mutation | c.1265N>T | p.Arg422Ile | p.R422I | P17025 | protein_coding | tolerated(0.06) | probably_damaging(0.983) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZNF182 | SNV | Missense_Mutation | novel | c.1365N>T | p.Glu455Asp | p.E455D | P17025 | protein_coding | deleterious(0.01) | benign(0.294) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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