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Gene: ZMAT3 |
Gene summary for ZMAT3 |
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Gene information | Species | Human | Gene symbol | ZMAT3 | Gene ID | 64393 |
Gene name | zinc finger matrin-type 3 | |
Gene Alias | PAG608 | |
Cytomap | 3q26.32 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9HA38 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64393 | ZMAT3 | LZE24T | Human | Esophagus | ESCC | 9.77e-15 | 1.87e-01 | 0.0596 |
64393 | ZMAT3 | P1T-E | Human | Esophagus | ESCC | 1.46e-02 | 2.33e-01 | 0.0875 |
64393 | ZMAT3 | P2T-E | Human | Esophagus | ESCC | 5.18e-22 | 5.40e-01 | 0.1177 |
64393 | ZMAT3 | P4T-E | Human | Esophagus | ESCC | 1.93e-12 | 2.12e-01 | 0.1323 |
64393 | ZMAT3 | P5T-E | Human | Esophagus | ESCC | 1.00e-08 | 2.05e-01 | 0.1327 |
64393 | ZMAT3 | P8T-E | Human | Esophagus | ESCC | 3.07e-11 | 2.27e-01 | 0.0889 |
64393 | ZMAT3 | P9T-E | Human | Esophagus | ESCC | 6.39e-09 | 2.64e-01 | 0.1131 |
64393 | ZMAT3 | P10T-E | Human | Esophagus | ESCC | 2.17e-24 | 3.55e-01 | 0.116 |
64393 | ZMAT3 | P11T-E | Human | Esophagus | ESCC | 1.44e-12 | 4.64e-01 | 0.1426 |
64393 | ZMAT3 | P12T-E | Human | Esophagus | ESCC | 2.85e-06 | 2.56e-01 | 0.1122 |
64393 | ZMAT3 | P15T-E | Human | Esophagus | ESCC | 1.43e-13 | 3.46e-01 | 0.1149 |
64393 | ZMAT3 | P16T-E | Human | Esophagus | ESCC | 1.34e-15 | 2.35e-01 | 0.1153 |
64393 | ZMAT3 | P17T-E | Human | Esophagus | ESCC | 8.78e-05 | 3.58e-01 | 0.1278 |
64393 | ZMAT3 | P20T-E | Human | Esophagus | ESCC | 2.16e-05 | 1.17e-01 | 0.1124 |
64393 | ZMAT3 | P21T-E | Human | Esophagus | ESCC | 2.10e-05 | 9.49e-02 | 0.1617 |
64393 | ZMAT3 | P22T-E | Human | Esophagus | ESCC | 5.00e-10 | 1.86e-01 | 0.1236 |
64393 | ZMAT3 | P23T-E | Human | Esophagus | ESCC | 7.06e-11 | 2.52e-01 | 0.108 |
64393 | ZMAT3 | P24T-E | Human | Esophagus | ESCC | 7.39e-09 | 1.69e-01 | 0.1287 |
64393 | ZMAT3 | P26T-E | Human | Esophagus | ESCC | 4.61e-68 | 1.15e+00 | 0.1276 |
64393 | ZMAT3 | P27T-E | Human | Esophagus | ESCC | 4.66e-15 | 2.23e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Stomach | WIM | ![]() |
Stomach | SIM | ![]() |
Liver | NAFLD | ![]() |
Liver | Cirrhotic | ![]() |
Liver | HCC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0411524 | Esophagus | ESCC | p53 signaling pathway | 65/4205 | 74/8465 | 3.88e-12 | 6.50e-11 | 3.33e-11 | 65 |
hsa0411534 | Esophagus | ESCC | p53 signaling pathway | 65/4205 | 74/8465 | 3.88e-12 | 6.50e-11 | 3.33e-11 | 65 |
hsa041156 | Liver | HCC | p53 signaling pathway | 46/4020 | 74/8465 | 7.64e-03 | 2.08e-02 | 1.16e-02 | 46 |
hsa0411511 | Liver | HCC | p53 signaling pathway | 46/4020 | 74/8465 | 7.64e-03 | 2.08e-02 | 1.16e-02 | 46 |
hsa041159 | Oral cavity | OSCC | p53 signaling pathway | 57/3704 | 74/8465 | 4.99e-09 | 5.07e-08 | 2.58e-08 | 57 |
hsa0411514 | Oral cavity | OSCC | p53 signaling pathway | 57/3704 | 74/8465 | 4.99e-09 | 5.07e-08 | 2.58e-08 | 57 |
hsa0411523 | Oral cavity | LP | p53 signaling pathway | 38/2418 | 74/8465 | 2.82e-05 | 1.92e-04 | 1.24e-04 | 38 |
hsa0411533 | Oral cavity | LP | p53 signaling pathway | 38/2418 | 74/8465 | 2.82e-05 | 1.92e-04 | 1.24e-04 | 38 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZMAT3 | SNV | Missense_Mutation | novel | c.44N>A | p.Pro15His | p.P15H | Q9HA38 | protein_coding | deleterious_low_confidence(0.04) | benign(0.156) | TCGA-E2-A15M-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
ZMAT3 | SNV | Missense_Mutation | novel | c.259G>T | p.Ala87Ser | p.A87S | Q9HA38 | protein_coding | tolerated(0.33) | probably_damaging(0.998) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ZMAT3 | SNV | Missense_Mutation | c.49N>T | p.Pro17Ser | p.P17S | Q9HA38 | protein_coding | tolerated_low_confidence(0.27) | benign(0) | TCGA-AA-3979-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZMAT3 | SNV | Missense_Mutation | novel | c.692N>T | p.Arg231Ile | p.R231I | Q9HA38 | protein_coding | deleterious(0.01) | possibly_damaging(0.606) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZMAT3 | SNV | Missense_Mutation | c.757N>A | p.Val253Ile | p.V253I | Q9HA38 | protein_coding | tolerated(0.43) | benign(0.134) | TCGA-CM-6169-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Ancillary | leucovorin | SD | |
ZMAT3 | SNV | Missense_Mutation | c.710C>T | p.Ala237Val | p.A237V | Q9HA38 | protein_coding | deleterious(0.01) | probably_damaging(0.991) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZMAT3 | SNV | Missense_Mutation | rs774816930 | c.700N>T | p.Arg234Cys | p.R234C | Q9HA38 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZMAT3 | SNV | Missense_Mutation | c.355N>T | p.Pro119Ser | p.P119S | Q9HA38 | protein_coding | tolerated(0.47) | benign(0.066) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ZMAT3 | SNV | Missense_Mutation | c.852N>T | p.Glu284Asp | p.E284D | Q9HA38 | protein_coding | deleterious(0.02) | probably_damaging(0.967) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ZMAT3 | SNV | Missense_Mutation | c.296N>A | p.Arg99Gln | p.R99Q | Q9HA38 | protein_coding | deleterious(0.01) | probably_damaging(0.988) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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