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Gene: WDR18 |
Gene summary for WDR18 |
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Gene information | Species | Human | Gene symbol | WDR18 | Gene ID | 57418 |
Gene name | WD repeat domain 18 | |
Gene Alias | Ipi3 | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9BV38 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57418 | WDR18 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.34e-09 | 1.85e-01 | 0.0155 |
57418 | WDR18 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.90e-06 | 1.69e-01 | -0.1808 |
57418 | WDR18 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.76e-04 | 1.77e-01 | -0.1088 |
57418 | WDR18 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.34e-10 | 2.42e-01 | -0.1954 |
57418 | WDR18 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.01e-05 | 4.10e-01 | -0.2602 |
57418 | WDR18 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.24e-04 | 1.96e-01 | -0.1207 |
57418 | WDR18 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.41e-13 | 3.09e-01 | -0.1464 |
57418 | WDR18 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.82e-04 | 1.76e-01 | -0.1001 |
57418 | WDR18 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.00e-17 | 4.19e-01 | -0.059 |
57418 | WDR18 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.23e-05 | 2.82e-01 | -0.1706 |
57418 | WDR18 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.82e-05 | 3.07e-01 | -0.1462 |
57418 | WDR18 | HTA11_546_2000001011 | Human | Colorectum | AD | 9.13e-04 | 2.17e-01 | -0.0842 |
57418 | WDR18 | HTA11_866_3004761011 | Human | Colorectum | AD | 5.87e-13 | 3.27e-01 | 0.096 |
57418 | WDR18 | HTA11_4255_2000001011 | Human | Colorectum | SER | 2.71e-05 | 3.34e-01 | 0.0446 |
57418 | WDR18 | HTA11_7663_2000001011 | Human | Colorectum | SER | 1.19e-08 | 4.48e-01 | 0.0131 |
57418 | WDR18 | HTA11_10623_2000001011 | Human | Colorectum | AD | 1.14e-10 | 4.09e-01 | -0.0177 |
57418 | WDR18 | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.14e-07 | 4.68e-01 | 0.0171 |
57418 | WDR18 | HTA11_10711_2000001011 | Human | Colorectum | AD | 6.55e-06 | 2.02e-01 | 0.0338 |
57418 | WDR18 | HTA11_7696_3000711011 | Human | Colorectum | AD | 7.60e-25 | 5.68e-01 | 0.0674 |
57418 | WDR18 | HTA11_7469_2000001011 | Human | Colorectum | AD | 6.53e-04 | 3.87e-01 | -0.0124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Stomach | WIM | ![]() |
Stomach | SIM | ![]() |
Liver | NAFLD | ![]() |
Liver | Cirrhotic | ![]() |
Liver | HCC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022613 | Colorectum | AD | ribonucleoprotein complex biogenesis | 151/3918 | 463/18723 | 1.96e-09 | 1.39e-07 | 151 |
GO:0051052 | Colorectum | AD | regulation of DNA metabolic process | 116/3918 | 359/18723 | 2.47e-07 | 1.00e-05 | 116 |
GO:0042254 | Colorectum | AD | ribosome biogenesis | 84/3918 | 299/18723 | 1.82e-03 | 1.50e-02 | 84 |
GO:00226131 | Colorectum | SER | ribonucleoprotein complex biogenesis | 112/2897 | 463/18723 | 5.01e-07 | 2.48e-05 | 112 |
GO:00510521 | Colorectum | SER | regulation of DNA metabolic process | 83/2897 | 359/18723 | 8.03e-05 | 1.77e-03 | 83 |
GO:00422541 | Colorectum | SER | ribosome biogenesis | 66/2897 | 299/18723 | 1.48e-03 | 1.60e-02 | 66 |
GO:00226132 | Colorectum | MSS | ribonucleoprotein complex biogenesis | 144/3467 | 463/18723 | 2.76e-11 | 3.67e-09 | 144 |
GO:00510522 | Colorectum | MSS | regulation of DNA metabolic process | 108/3467 | 359/18723 | 5.86e-08 | 3.10e-06 | 108 |
GO:00422542 | Colorectum | MSS | ribosome biogenesis | 79/3467 | 299/18723 | 4.32e-04 | 5.23e-03 | 79 |
GO:0006364 | Colorectum | MSS | rRNA processing | 58/3467 | 225/18723 | 4.17e-03 | 3.03e-02 | 58 |
GO:0016072 | Colorectum | MSS | rRNA metabolic process | 60/3467 | 236/18723 | 5.01e-03 | 3.46e-02 | 60 |
GO:00226133 | Colorectum | MSI-H | ribonucleoprotein complex biogenesis | 95/1319 | 463/18723 | 1.04e-21 | 8.32e-19 | 95 |
GO:00422543 | Colorectum | MSI-H | ribosome biogenesis | 54/1319 | 299/18723 | 1.27e-10 | 2.07e-08 | 54 |
GO:00063641 | Colorectum | MSI-H | rRNA processing | 39/1319 | 225/18723 | 1.45e-07 | 1.32e-05 | 39 |
GO:00160721 | Colorectum | MSI-H | rRNA metabolic process | 39/1319 | 236/18723 | 5.20e-07 | 3.91e-05 | 39 |
GO:00510523 | Colorectum | MSI-H | regulation of DNA metabolic process | 45/1319 | 359/18723 | 1.20e-04 | 3.56e-03 | 45 |
GO:0034470 | Colorectum | MSI-H | ncRNA processing | 48/1319 | 395/18723 | 1.54e-04 | 4.47e-03 | 48 |
GO:0034660 | Colorectum | MSI-H | ncRNA metabolic process | 53/1319 | 485/18723 | 9.66e-04 | 1.68e-02 | 53 |
GO:0006260 | Colorectum | MSI-H | DNA replication | 31/1319 | 260/18723 | 2.83e-03 | 3.63e-02 | 31 |
GO:002261327 | Esophagus | HGIN | ribonucleoprotein complex biogenesis | 158/2587 | 463/18723 | 2.61e-29 | 5.23e-26 | 158 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WDR18 | SNV | Missense_Mutation | novel | c.146N>A | p.Gly49Asp | p.G49D | Q9BV38 | protein_coding | tolerated(0.05) | possibly_damaging(0.814) | TCGA-JL-A3YW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
WDR18 | SNV | Missense_Mutation | rs778985723 | c.827C>T | p.Ser276Leu | p.S276L | Q9BV38 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
WDR18 | insertion | Frame_Shift_Ins | novel | c.631_632insG | p.Ser211CysfsTer5 | p.S211Cfs*5 | Q9BV38 | protein_coding | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | ||
WDR18 | insertion | Frame_Shift_Ins | novel | c.632_633insA | p.Val212ArgfsTer4 | p.V212Rfs*4 | Q9BV38 | protein_coding | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | ||
WDR18 | SNV | Missense_Mutation | c.697N>A | p.Gly233Arg | p.G233R | Q9BV38 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |
WDR18 | deletion | Frame_Shift_Del | novel | c.619delG | p.Glu207SerfsTer15 | p.E207Sfs*15 | Q9BV38 | protein_coding | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
WDR18 | SNV | Missense_Mutation | rs376924638 | c.1195C>T | p.Arg399Cys | p.R399C | Q9BV38 | protein_coding | deleterious(0.03) | possibly_damaging(0.828) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WDR18 | SNV | Missense_Mutation | rs376924638 | c.1195C>T | p.Arg399Cys | p.R399C | Q9BV38 | protein_coding | deleterious(0.03) | possibly_damaging(0.828) | TCGA-A5-A0GG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WDR18 | SNV | Missense_Mutation | novel | c.26N>A | p.Val9Glu | p.V9E | Q9BV38 | protein_coding | deleterious(0) | possibly_damaging(0.593) | TCGA-AP-A1DO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
WDR18 | SNV | Missense_Mutation | rs775172395 | c.868N>A | p.Asp290Asn | p.D290N | Q9BV38 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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