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Gene: TYMSOS |
Gene summary for TYMSOS |
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Gene information | Species | Human | Gene symbol | TYMSOS | Gene ID | 494514 |
Gene name | TYMS opposite strand RNA | |
Gene Alias | C18orf56 | |
Cytomap | 18p11.32 | |
Gene Type | ncRNA | GO ID | GO:0003674 | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
494514 | TYMSOS | LZE2T | Human | Esophagus | ESCC | 7.58e-06 | 8.37e-01 | 0.082 |
494514 | TYMSOS | LZE22T | Human | Esophagus | ESCC | 4.00e-04 | 2.90e-01 | 0.068 |
494514 | TYMSOS | LZE6T | Human | Esophagus | ESCC | 4.29e-17 | 6.89e-01 | 0.0845 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Stomach | WIM | ![]() |
Stomach | SIM | ![]() |
Liver | NAFLD | ![]() |
Liver | Cirrhotic | ![]() |
Liver | HCC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
494514 | TYMSOS | NA | azathioprine | AZATHIOPRINE | 26332308 | |
494514 | TYMSOS | NA | capecitabine | CAPECITABINE | 25677447 | |
494514 | TYMSOS | NA | cytarabine | CYTARABINE | ||
494514 | TYMSOS | NA | daunorubicin | DAUNORUBICIN | ||
494514 | TYMSOS | NA | dexamethasone | DEXAMETHASONE | ||
494514 | TYMSOS | NA | folic acid | 18322994 | ||
494514 | TYMSOS | NA | prednisone | PREDNISONE | ||
494514 | TYMSOS | NA | hydroxychloroquine | HYDROXYCHLOROQUINE | 18322994 | |
494514 | TYMSOS | NA | asparaginase | ASPARAGINASE | ||
494514 | TYMSOS | NA | mercaptopurine | MERCAPTOPURINE |
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