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Gene: TTYH1 |
Gene summary for TTYH1 |
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Gene information | Species | Human | Gene symbol | TTYH1 | Gene ID | 57348 |
Gene name | tweety family member 1 | |
Gene Alias | TTYH1 | |
Cytomap | 19q13.42 | |
Gene Type | protein-coding | GO ID | GO:0000041 | UniProtAcc | Q9H313 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57348 | TTYH1 | GSM4909281 | Human | Breast | IDC | 2.68e-37 | 6.99e-01 | 0.21 |
57348 | TTYH1 | GSM4909282 | Human | Breast | IDC | 2.15e-05 | 2.59e-01 | -0.0288 |
57348 | TTYH1 | GSM4909285 | Human | Breast | IDC | 6.08e-85 | 1.15e+00 | 0.21 |
57348 | TTYH1 | GSM4909286 | Human | Breast | IDC | 1.44e-71 | 9.19e-01 | 0.1081 |
57348 | TTYH1 | GSM4909288 | Human | Breast | IDC | 3.30e-05 | 6.24e-01 | 0.0988 |
57348 | TTYH1 | GSM4909308 | Human | Breast | IDC | 2.82e-02 | -1.26e-01 | 0.158 |
57348 | TTYH1 | brca10 | Human | Breast | Precancer | 4.07e-02 | -1.26e-01 | -0.0029 |
57348 | TTYH1 | DCIS2 | Human | Breast | DCIS | 6.68e-19 | 8.01e-02 | 0.0085 |
57348 | TTYH1 | P11T-E | Human | Esophagus | ESCC | 3.07e-05 | 4.08e-01 | 0.1426 |
57348 | TTYH1 | P19T-E | Human | Esophagus | ESCC | 3.80e-02 | 4.56e-01 | 0.1662 |
57348 | TTYH1 | P76T-E | Human | Esophagus | ESCC | 2.00e-21 | 7.31e-01 | 0.1207 |
57348 | TTYH1 | P82T-E | Human | Esophagus | ESCC | 2.37e-04 | 4.30e-01 | 0.1072 |
57348 | TTYH1 | P126T-E | Human | Esophagus | ESCC | 4.48e-02 | 6.28e-01 | 0.1125 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Stomach | WIM | ![]() |
Stomach | SIM | ![]() |
Liver | NAFLD | ![]() |
Liver | Cirrhotic | ![]() |
Liver | HCC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00068263 | Breast | Precancer | iron ion transport | 9/1080 | 58/18723 | 5.67e-03 | 4.08e-02 | 9 |
GO:00000412 | Breast | Precancer | transition metal ion transport | 13/1080 | 105/18723 | 7.35e-03 | 4.89e-02 | 13 |
GO:000682611 | Breast | IDC | iron ion transport | 11/1434 | 58/18723 | 4.10e-03 | 3.25e-02 | 11 |
GO:000682621 | Breast | DCIS | iron ion transport | 11/1390 | 58/18723 | 3.23e-03 | 2.73e-02 | 11 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TTYH1 | SNV | Missense_Mutation | c.1205C>T | p.Ser402Phe | p.S402F | Q9H313 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-A2-A0CM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | PD | |
TTYH1 | SNV | Missense_Mutation | rs762277818 | c.728N>G | p.Val243Gly | p.V243G | Q9H313 | protein_coding | deleterious(0) | possibly_damaging(0.885) | TCGA-A2-A0CS-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD |
TTYH1 | SNV | Missense_Mutation | c.857C>G | p.Thr286Ser | p.T286S | Q9H313 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-A2-A1FZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Arimidex | SD | |
TTYH1 | SNV | Missense_Mutation | rs762277818 | c.728N>G | p.Val243Gly | p.V243G | Q9H313 | protein_coding | deleterious(0) | possibly_damaging(0.885) | TCGA-E2-A1LA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
TTYH1 | insertion | Frame_Shift_Ins | novel | c.1331_1332insTAACAATGCTATGAAGAAGGAACTAT | p.Glu444AspfsTer36 | p.E444Dfs*36 | Q9H313 | protein_coding | TCGA-A7-A0CJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
TTYH1 | SNV | Missense_Mutation | rs555603023 | c.218N>A | p.Arg73Gln | p.R73Q | Q9H313 | protein_coding | tolerated(0.05) | possibly_damaging(0.772) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TTYH1 | SNV | Missense_Mutation | rs769313856 | c.494N>A | p.Arg165His | p.R165H | Q9H313 | protein_coding | tolerated(0.05) | probably_damaging(0.991) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TTYH1 | SNV | Missense_Mutation | novel | c.1211N>C | p.Gly404Ala | p.G404A | Q9H313 | protein_coding | tolerated(0.5) | possibly_damaging(0.54) | TCGA-C5-A902-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
TTYH1 | SNV | Missense_Mutation | rs752829139 | c.221N>A | p.Pro74His | p.P74H | Q9H313 | protein_coding | tolerated(0.1) | possibly_damaging(0.506) | TCGA-EK-A2RN-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TTYH1 | SNV | Missense_Mutation | c.1141N>A | p.Leu381Met | p.L381M | Q9H313 | protein_coding | tolerated(0.06) | probably_damaging(0.992) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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