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Gene: TMA16 |
Gene summary for TMA16 |
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Gene information | Species | Human | Gene symbol | TMA16 | Gene ID | 55319 |
Gene name | translation machinery associated 16 homolog | |
Gene Alias | C4orf43 | |
Cytomap | 4q32.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q96EY4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55319 | TMA16 | GSM4909282 | Human | Breast | IDC | 2.30e-11 | 4.30e-01 | -0.0288 |
55319 | TMA16 | GSM4909311 | Human | Breast | IDC | 4.11e-06 | 4.08e-02 | 0.1534 |
55319 | TMA16 | GSM4909315 | Human | Breast | IDC | 3.45e-38 | 8.91e-01 | 0.21 |
55319 | TMA16 | GSM4909316 | Human | Breast | IDC | 1.22e-22 | 8.64e-01 | 0.21 |
55319 | TMA16 | GSM4909319 | Human | Breast | IDC | 1.03e-14 | 5.41e-02 | 0.1563 |
55319 | TMA16 | GSM4909320 | Human | Breast | IDC | 4.20e-03 | 2.21e-01 | 0.1575 |
55319 | TMA16 | brca2 | Human | Breast | Precancer | 3.98e-05 | 1.75e-01 | -0.024 |
55319 | TMA16 | P1 | Human | Breast | IDC | 9.46e-03 | -3.02e-02 | 0.1527 |
55319 | TMA16 | DCIS2 | Human | Breast | DCIS | 1.09e-34 | 6.26e-02 | 0.0085 |
55319 | TMA16 | LZE4T | Human | Esophagus | ESCC | 4.38e-09 | 1.76e-01 | 0.0811 |
55319 | TMA16 | LZE8T | Human | Esophagus | ESCC | 1.46e-02 | -1.48e-02 | 0.067 |
55319 | TMA16 | LZE24T | Human | Esophagus | ESCC | 7.21e-10 | 8.00e-02 | 0.0596 |
55319 | TMA16 | LZE6T | Human | Esophagus | ESCC | 3.80e-02 | -2.00e-02 | 0.0845 |
55319 | TMA16 | P1T-E | Human | Esophagus | ESCC | 1.43e-09 | 2.88e-01 | 0.0875 |
55319 | TMA16 | P2T-E | Human | Esophagus | ESCC | 2.30e-23 | 5.21e-01 | 0.1177 |
55319 | TMA16 | P4T-E | Human | Esophagus | ESCC | 7.40e-06 | 2.04e-01 | 0.1323 |
55319 | TMA16 | P5T-E | Human | Esophagus | ESCC | 1.20e-20 | 2.66e-01 | 0.1327 |
55319 | TMA16 | P8T-E | Human | Esophagus | ESCC | 4.01e-20 | 1.77e-01 | 0.0889 |
55319 | TMA16 | P9T-E | Human | Esophagus | ESCC | 1.36e-08 | 1.55e-01 | 0.1131 |
55319 | TMA16 | P10T-E | Human | Esophagus | ESCC | 1.66e-13 | 2.30e-01 | 0.116 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Stomach | WIM | ![]() |
Stomach | SIM | ![]() |
Liver | NAFLD | ![]() |
Liver | Cirrhotic | ![]() |
Liver | HCC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMA16 | SNV | Missense_Mutation | c.78N>T | p.Gln26His | p.Q26H | Q96EY4 | protein_coding | deleterious(0.01) | probably_damaging(0.979) | TCGA-C8-A1HI-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
TMA16 | SNV | Missense_Mutation | novel | c.175N>G | p.Gln59Glu | p.Q59E | Q96EY4 | protein_coding | deleterious(0) | possibly_damaging(0.6) | TCGA-C5-A8XH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TMA16 | SNV | Missense_Mutation | c.602C>T | p.Ala201Val | p.A201V | Q96EY4 | protein_coding | tolerated_low_confidence(0.09) | benign(0.127) | TCGA-AA-3522-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TMA16 | SNV | Missense_Mutation | novel | c.106N>C | p.Lys36Gln | p.K36Q | Q96EY4 | protein_coding | deleterious(0.01) | probably_damaging(0.939) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TMA16 | SNV | Missense_Mutation | c.181N>A | p.His61Asn | p.H61N | Q96EY4 | protein_coding | tolerated(0.33) | benign(0.031) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
TMA16 | SNV | Missense_Mutation | novel | c.152N>C | p.Val51Ala | p.V51A | Q96EY4 | protein_coding | deleterious(0.04) | benign(0.02) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TMA16 | SNV | Missense_Mutation | novel | c.455N>C | p.Lys152Thr | p.K152T | Q96EY4 | protein_coding | tolerated(0.15) | benign(0.306) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TMA16 | SNV | Missense_Mutation | c.474N>A | p.Met158Ile | p.M158I | Q96EY4 | protein_coding | tolerated(0.13) | possibly_damaging(0.776) | TCGA-DC-6154-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | SD | |
TMA16 | insertion | Frame_Shift_Ins | rs768974165 | c.200dupA | p.Arg68GlufsTer9 | p.R68Efs*9 | Q96EY4 | protein_coding | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
TMA16 | SNV | Missense_Mutation | novel | c.296G>T | p.Arg99Met | p.R99M | Q96EY4 | protein_coding | deleterious(0) | possibly_damaging(0.455) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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