GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000697922 | Liver | HCC | response to oxidative stress | 281/7958 | 446/18723 | 9.75e-19 | 1.24e-16 | 281 |
GO:004325422 | Liver | HCC | regulation of protein-containing complex assembly | 264/7958 | 428/18723 | 5.47e-16 | 4.39e-14 | 264 |
GO:006219722 | Liver | HCC | cellular response to chemical stress | 216/7958 | 337/18723 | 6.86e-16 | 5.44e-14 | 216 |
GO:003459922 | Liver | HCC | cellular response to oxidative stress | 183/7958 | 288/18723 | 3.65e-13 | 1.93e-11 | 183 |
GO:003133412 | Liver | HCC | positive regulation of protein-containing complex assembly | 150/7958 | 237/18723 | 7.35e-11 | 2.63e-09 | 150 |
GO:190165321 | Liver | HCC | cellular response to peptide | 211/7958 | 359/18723 | 2.86e-10 | 9.63e-09 | 211 |
GO:00022211 | Liver | HCC | pattern recognition receptor signaling pathway | 107/7958 | 172/18723 | 1.37e-07 | 2.58e-06 | 107 |
GO:007099722 | Liver | HCC | neuron death | 202/7958 | 361/18723 | 1.44e-07 | 2.70e-06 | 202 |
GO:190121412 | Liver | HCC | regulation of neuron death | 179/7958 | 319/18723 | 5.65e-07 | 9.01e-06 | 179 |
GO:000724912 | Liver | HCC | I-kappaB kinase/NF-kappaB signaling | 156/7958 | 281/18723 | 6.66e-06 | 8.00e-05 | 156 |
GO:004312312 | Liver | HCC | positive regulation of I-kappaB kinase/NF-kappaB signaling | 108/7958 | 186/18723 | 1.28e-05 | 1.43e-04 | 108 |
GO:190121612 | Liver | HCC | positive regulation of neuron death | 62/7958 | 97/18723 | 1.67e-05 | 1.81e-04 | 62 |
GO:004312212 | Liver | HCC | regulation of I-kappaB kinase/NF-kappaB signaling | 138/7958 | 249/18723 | 2.47e-05 | 2.58e-04 | 138 |
GO:200037722 | Liver | HCC | regulation of reactive oxygen species metabolic process | 92/7958 | 157/18723 | 3.34e-05 | 3.35e-04 | 92 |
GO:007190021 | Liver | HCC | regulation of protein serine/threonine kinase activity | 189/7958 | 359/18723 | 5.97e-05 | 5.47e-04 | 189 |
GO:200105722 | Liver | HCC | reactive nitrogen species metabolic process | 51/7958 | 82/18723 | 2.50e-04 | 1.86e-03 | 51 |
GO:004620922 | Liver | HCC | nitric oxide metabolic process | 50/7958 | 81/18723 | 3.72e-04 | 2.56e-03 | 50 |
GO:008016422 | Liver | HCC | regulation of nitric oxide metabolic process | 41/7958 | 64/18723 | 4.06e-04 | 2.74e-03 | 41 |
GO:200037912 | Liver | HCC | positive regulation of reactive oxygen species metabolic process | 47/7958 | 76/18723 | 5.19e-04 | 3.38e-03 | 47 |
GO:00510902 | Liver | HCC | regulation of DNA-binding transcription factor activity | 220/7958 | 440/18723 | 8.04e-04 | 4.82e-03 | 220 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TLR6 | SNV | Missense_Mutation | novel | c.2030N>T | p.Asn677Ile | p.N677I | Q9Y2C9 | protein_coding | deleterious(0) | probably_damaging(0.949) | TCGA-AC-A8OR-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TLR6 | SNV | Missense_Mutation | rs374402826 | c.2143N>A | p.Glu715Lys | p.E715K | Q9Y2C9 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TLR6 | insertion | Nonsense_Mutation | novel | c.2140_2141insGTAAAGGGATATATGGACTTAATCATAAGCTGTTGAGGTGAAAG | p.Tyr714CysfsTer14 | p.Y714Cfs*14 | Q9Y2C9 | protein_coding | | | TCGA-A2-A0EO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
TLR6 | insertion | Nonsense_Mutation | novel | c.234_235insTGAATGCTCAAGTCCCTTATGTAAAATGGCATACTTCCAAC | p.Thr79Ter | p.T79* | Q9Y2C9 | protein_coding | | | TCGA-A2-A0EO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
TLR6 | insertion | In_Frame_Ins | novel | c.1824_1825insGGTGAGGTT | p.Tyr608_Leu609insGlyGluVal | p.Y608_L609insGEV | Q9Y2C9 | protein_coding | | | TCGA-AN-A049-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TLR6 | insertion | Nonsense_Mutation | novel | c.932_933insGTATCAAGTGAAGTGTTAGAGGGCTGGCCTGATTCTTATAAGTGTG | p.His311GlnfsTer7 | p.H311Qfs*7 | Q9Y2C9 | protein_coding | | | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
TLR6 | SNV | Missense_Mutation | novel | c.656C>T | p.Thr219Ile | p.T219I | Q9Y2C9 | protein_coding | deleterious(0.03) | benign(0.127) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TLR6 | SNV | Missense_Mutation | rs374402826 | c.2143G>A | p.Glu715Lys | p.E715K | Q9Y2C9 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD |
TLR6 | SNV | Missense_Mutation | novel | c.2025N>T | p.Glu675Asp | p.E675D | Q9Y2C9 | protein_coding | deleterious(0) | possibly_damaging(0.693) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TLR6 | SNV | Missense_Mutation | | c.784N>G | p.Thr262Ala | p.T262A | Q9Y2C9 | protein_coding | tolerated(0.54) | benign(0.031) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |