GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:20012338 | Lung | IAC | regulation of apoptotic signaling pathway | 82/2061 | 356/18723 | 4.85e-11 | 1.44e-08 | 82 |
GO:00160556 | Lung | IAC | Wnt signaling pathway | 95/2061 | 444/18723 | 1.13e-10 | 2.80e-08 | 95 |
GO:01987386 | Lung | IAC | cell-cell signaling by wnt | 95/2061 | 446/18723 | 1.46e-10 | 3.48e-08 | 95 |
GO:00301116 | Lung | IAC | regulation of Wnt signaling pathway | 74/2061 | 328/18723 | 1.14e-09 | 2.05e-07 | 74 |
GO:00447723 | Lung | IAC | mitotic cell cycle phase transition | 85/2061 | 424/18723 | 2.69e-08 | 3.20e-06 | 85 |
GO:20012348 | Lung | IAC | negative regulation of apoptotic signaling pathway | 52/2061 | 224/18723 | 1.25e-07 | 1.11e-05 | 52 |
GO:00362947 | Lung | IAC | cellular response to decreased oxygen levels | 41/2061 | 161/18723 | 1.92e-07 | 1.59e-05 | 41 |
GO:00714537 | Lung | IAC | cellular response to oxygen levels | 43/2061 | 177/18723 | 4.03e-07 | 2.82e-05 | 43 |
GO:00316478 | Lung | IAC | regulation of protein stability | 62/2061 | 298/18723 | 5.37e-07 | 3.32e-05 | 62 |
GO:00714564 | Lung | IAC | cellular response to hypoxia | 38/2061 | 151/18723 | 7.33e-07 | 4.14e-05 | 38 |
GO:20012368 | Lung | IAC | regulation of extrinsic apoptotic signaling pathway | 38/2061 | 151/18723 | 7.33e-07 | 4.14e-05 | 38 |
GO:00362938 | Lung | IAC | response to decreased oxygen levels | 64/2061 | 322/18723 | 1.87e-06 | 8.87e-05 | 64 |
GO:00609646 | Lung | IAC | regulation of gene silencing by miRNA | 18/2061 | 49/18723 | 2.10e-06 | 9.45e-05 | 18 |
GO:00616147 | Lung | IAC | pri-miRNA transcription by RNA polymerase II | 19/2061 | 55/18723 | 3.20e-06 | 1.38e-04 | 19 |
GO:00016668 | Lung | IAC | response to hypoxia | 61/2061 | 307/18723 | 3.26e-06 | 1.39e-04 | 61 |
GO:00971918 | Lung | IAC | extrinsic apoptotic signaling pathway | 47/2061 | 219/18723 | 5.11e-06 | 2.03e-04 | 47 |
GO:00351965 | Lung | IAC | production of miRNAs involved in gene silencing by miRNA | 18/2061 | 52/18723 | 5.60e-06 | 2.13e-04 | 18 |
GO:00601475 | Lung | IAC | regulation of posttranscriptional gene silencing | 18/2061 | 52/18723 | 5.60e-06 | 2.13e-04 | 18 |
GO:00000823 | Lung | IAC | G1/S transition of mitotic cell cycle | 46/2061 | 214/18723 | 6.13e-06 | 2.29e-04 | 46 |
GO:00709978 | Lung | IAC | neuron death | 68/2061 | 361/18723 | 6.32e-06 | 2.32e-04 | 68 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TERT | SNV | Missense_Mutation | | c.2929N>C | p.Val977Leu | p.V977L | O14746 | protein_coding | tolerated(0.05) | possibly_damaging(0.863) | TCGA-A8-A08F-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR |
TERT | SNV | Missense_Mutation | | c.2633N>A | p.Thr878Asn | p.T878N | O14746 | protein_coding | tolerated(0.21) | benign(0.178) | TCGA-D8-A3Z6-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphane | SD |
TERT | SNV | Missense_Mutation | rs374968697 | c.3103N>A | p.Val1035Ile | p.V1035I | O14746 | protein_coding | tolerated(1) | benign(0.028) | TCGA-WT-AB41-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
TERT | insertion | Frame_Shift_Ins | novel | c.1704_1705insA | p.Gln569ThrfsTer60 | p.Q569Tfs*60 | O14746 | protein_coding | | | TCGA-AN-A049-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TERT | insertion | Frame_Shift_Ins | novel | c.1702_1703insGTCCCGCCCAGGCTGACTGTGGAGGGCT | p.Phe568CysfsTer70 | p.F568Cfs*70 | O14746 | protein_coding | | | TCGA-AN-A049-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TERT | deletion | Frame_Shift_Del | novel | c.2465delN | p.Gly822AlafsTer52 | p.G822Afs*52 | O14746 | protein_coding | | | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
TERT | SNV | Missense_Mutation | novel | c.1562G>A | p.Arg521His | p.R521H | O14746 | protein_coding | tolerated(0.07) | benign(0.284) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TERT | SNV | Missense_Mutation | novel | c.1880N>A | p.Pro627His | p.P627H | O14746 | protein_coding | deleterious(0.03) | possibly_damaging(0.808) | TCGA-C5-A7CK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
TERT | SNV | Missense_Mutation | novel | c.1466N>A | p.Arg489Lys | p.R489K | O14746 | protein_coding | tolerated(1) | benign(0.039) | TCGA-EK-A2PI-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
TERT | SNV | Missense_Mutation | novel | c.1553N>T | p.Ala518Val | p.A518V | O14746 | protein_coding | tolerated(0.28) | benign(0.046) | TCGA-MA-AA3Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7015 | TERT | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, ENZYME, RNA DIRECTED DNA POLYMERASE, DRUG RESISTANCE | | KML-001 | | |
7015 | TERT | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, ENZYME, RNA DIRECTED DNA POLYMERASE, DRUG RESISTANCE | | TeloB-Vax | | |
7015 | TERT | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, ENZYME, RNA DIRECTED DNA POLYMERASE, DRUG RESISTANCE | | Dendritic cell vaccine | | |
7015 | TERT | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, ENZYME, RNA DIRECTED DNA POLYMERASE, DRUG RESISTANCE | | NSC-728558 | CHEMBL457246 | 19167892 |
7015 | TERT | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, ENZYME, RNA DIRECTED DNA POLYMERASE, DRUG RESISTANCE | | UO126 | | 28215740 |
7015 | TERT | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, ENZYME, RNA DIRECTED DNA POLYMERASE, DRUG RESISTANCE | | Imetelstat | IMETELSTAT | |
7015 | TERT | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, ENZYME, RNA DIRECTED DNA POLYMERASE, DRUG RESISTANCE | | RALOXIFENE | RALOXIFENE | 15590986 |
7015 | TERT | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, ENZYME, RNA DIRECTED DNA POLYMERASE, DRUG RESISTANCE | | OBP-301 | | |
7015 | TERT | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, ENZYME, RNA DIRECTED DNA POLYMERASE, DRUG RESISTANCE | | GRNVAC1 | | |
7015 | TERT | DRUGGABLE GENOME, CLINICALLY ACTIONABLE, ENZYME, RNA DIRECTED DNA POLYMERASE, DRUG RESISTANCE | | Berberine | BERBERINE | |