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Gene: SPATA5 |
Gene summary for SPATA5 |
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Gene information | Species | Human | Gene symbol | SPATA5 | Gene ID | 166378 |
Gene name | spermatogenesis associated 5 | |
Gene Alias | AFG2 | |
Cytomap | 4q28.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q8NB90 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
166378 | SPATA5 | CCI_1 | Human | Cervix | CC | 4.42e-07 | 7.10e-01 | 0.528 |
166378 | SPATA5 | CCI_2 | Human | Cervix | CC | 8.95e-10 | 6.63e-01 | 0.5249 |
166378 | SPATA5 | CCI_3 | Human | Cervix | CC | 4.49e-16 | 8.11e-01 | 0.516 |
166378 | SPATA5 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.36e-13 | -5.35e-01 | 0.0155 |
166378 | SPATA5 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.17e-03 | -5.25e-01 | -0.1207 |
166378 | SPATA5 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.26e-02 | -4.62e-01 | -0.1526 |
166378 | SPATA5 | HTA11_696_2000001011 | Human | Colorectum | AD | 9.37e-10 | -4.25e-01 | -0.1464 |
166378 | SPATA5 | HTA11_866_2000001011 | Human | Colorectum | AD | 7.59e-04 | -3.71e-01 | -0.1001 |
166378 | SPATA5 | HTA11_866_3004761011 | Human | Colorectum | AD | 9.48e-09 | -4.71e-01 | 0.096 |
166378 | SPATA5 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.09e-06 | -3.49e-01 | 0.0674 |
166378 | SPATA5 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.96e-09 | -4.22e-01 | 0.294 |
166378 | SPATA5 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.30e-03 | -3.58e-01 | 0.3859 |
166378 | SPATA5 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 8.08e-06 | -6.29e-01 | 0.2585 |
166378 | SPATA5 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.07e-17 | -5.19e-01 | 0.3005 |
166378 | SPATA5 | A001-C-207 | Human | Colorectum | FAP | 3.64e-03 | -2.71e-01 | 0.1278 |
166378 | SPATA5 | A015-C-203 | Human | Colorectum | FAP | 9.57e-24 | -4.78e-01 | -0.1294 |
166378 | SPATA5 | A015-C-204 | Human | Colorectum | FAP | 3.57e-08 | -4.26e-01 | -0.0228 |
166378 | SPATA5 | A014-C-040 | Human | Colorectum | FAP | 5.52e-03 | -3.60e-01 | -0.1184 |
166378 | SPATA5 | A002-C-201 | Human | Colorectum | FAP | 5.18e-13 | -4.39e-01 | 0.0324 |
166378 | SPATA5 | A001-C-119 | Human | Colorectum | FAP | 1.09e-08 | -5.16e-01 | -0.1557 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Stomach | WIM | ![]() |
Stomach | SIM | ![]() |
Liver | NAFLD | ![]() |
Liver | Cirrhotic | ![]() |
Liver | HCC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SPATA5 | SNV | Missense_Mutation | novel | c.1733N>A | p.Arg578Lys | p.R578K | Q8NB90 | protein_coding | tolerated(0.06) | benign(0.298) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
SPATA5 | SNV | Missense_Mutation | novel | c.992G>T | p.Arg331Ile | p.R331I | Q8NB90 | protein_coding | deleterious(0.01) | possibly_damaging(0.472) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SPATA5 | SNV | Missense_Mutation | c.430N>G | p.Met144Val | p.M144V | Q8NB90 | protein_coding | tolerated(1) | benign(0) | TCGA-AN-A0FZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
SPATA5 | SNV | Missense_Mutation | c.1576N>T | p.Ala526Ser | p.A526S | Q8NB90 | protein_coding | tolerated(0.17) | benign(0.236) | TCGA-BH-A0DE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SPATA5 | SNV | Missense_Mutation | novel | c.1435A>G | p.Thr479Ala | p.T479A | Q8NB90 | protein_coding | tolerated(0.1) | benign(0.172) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SPATA5 | SNV | Missense_Mutation | novel | c.53C>T | p.Ser18Leu | p.S18L | Q8NB90 | protein_coding | tolerated_low_confidence(0.06) | benign(0.103) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
SPATA5 | SNV | Missense_Mutation | novel | c.400N>G | p.Leu134Val | p.L134V | Q8NB90 | protein_coding | tolerated(0.6) | benign(0.003) | TCGA-EA-A3Y4-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
SPATA5 | SNV | Missense_Mutation | c.1597N>T | p.Leu533Phe | p.L533F | Q8NB90 | protein_coding | deleterious(0.02) | benign(0.402) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
SPATA5 | deletion | In_Frame_Del | novel | c.573_581delNNNNNNNNN | p.Leu193_Val195del | p.L193_V195del | Q8NB90 | protein_coding | TCGA-VS-A9UY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | ||
SPATA5 | SNV | Missense_Mutation | c.1041N>T | p.Gln347His | p.Q347H | Q8NB90 | protein_coding | tolerated(0.09) | benign(0.289) | TCGA-A6-2675-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
166378 | SPATA5 | NA | paclitaxel | PACLITAXEL | 24444404 |
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