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Gene: SNHG3 |
Gene summary for SNHG3 |
Gene summary. |
Gene information | Species | Human | Gene symbol | SNHG3 | Gene ID | 8420 |
Gene name | small nucleolar RNA host gene 3 | |
Gene Alias | NCRNA00014 | |
Cytomap | 1p35.3 | |
Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8420 | SNHG3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.63e-18 | 3.81e-01 | 0.0155 |
8420 | SNHG3 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.14e-15 | 4.98e-01 | -0.1808 |
8420 | SNHG3 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.30e-28 | 7.79e-01 | -0.0811 |
8420 | SNHG3 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.48e-07 | 2.34e-01 | -0.1088 |
8420 | SNHG3 | HTA11_347_2000001011 | Human | Colorectum | AD | 8.14e-12 | 2.40e-01 | -0.1954 |
8420 | SNHG3 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.57e-07 | 3.30e-01 | -0.1207 |
8420 | SNHG3 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.16e-09 | 4.19e-01 | -0.1526 |
8420 | SNHG3 | HTA11_696_2000001011 | Human | Colorectum | AD | 6.20e-20 | 3.71e-01 | -0.1464 |
8420 | SNHG3 | HTA11_866_2000001011 | Human | Colorectum | AD | 9.36e-06 | 1.48e-01 | -0.1001 |
8420 | SNHG3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.12e-18 | 6.16e-01 | -0.059 |
8420 | SNHG3 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.44e-03 | 1.99e-01 | -0.0842 |
8420 | SNHG3 | HTA11_7862_2000001011 | Human | Colorectum | AD | 5.15e-10 | 4.52e-01 | -0.0179 |
8420 | SNHG3 | HTA11_866_3004761011 | Human | Colorectum | AD | 9.64e-19 | 4.25e-01 | 0.096 |
8420 | SNHG3 | HTA11_4255_2000001011 | Human | Colorectum | SER | 1.20e-12 | 8.17e-01 | 0.0446 |
8420 | SNHG3 | HTA11_7663_2000001011 | Human | Colorectum | SER | 7.58e-09 | 5.21e-01 | 0.0131 |
8420 | SNHG3 | HTA11_10623_2000001011 | Human | Colorectum | AD | 1.79e-09 | 4.37e-01 | -0.0177 |
8420 | SNHG3 | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.64e-05 | 4.43e-01 | 0.0171 |
8420 | SNHG3 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.37e-08 | 3.54e-01 | 0.0338 |
8420 | SNHG3 | HTA11_7696_3000711011 | Human | Colorectum | AD | 5.18e-24 | 4.86e-01 | 0.0674 |
8420 | SNHG3 | HTA11_6818_2000001011 | Human | Colorectum | AD | 1.38e-07 | 2.91e-01 | 0.0112 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Stomach | WIM | |
Stomach | SIM | |
Liver | NAFLD | |
Liver | Cirrhotic | |
Liver | HCC |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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