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Gene: SMDT1 |
Gene summary for SMDT1 |
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Gene information | Species | Human | Gene symbol | SMDT1 | Gene ID | 91689 |
Gene name | single-pass membrane protein with aspartate rich tail 1 | |
Gene Alias | C22orf32 | |
Cytomap | 22q13.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9H4I9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
91689 | SMDT1 | GSM4909282 | Human | Breast | IDC | 1.37e-05 | -3.24e-01 | -0.0288 |
91689 | SMDT1 | GSM4909285 | Human | Breast | IDC | 3.45e-23 | -5.36e-01 | 0.21 |
91689 | SMDT1 | GSM4909286 | Human | Breast | IDC | 1.67e-03 | 8.29e-02 | 0.1081 |
91689 | SMDT1 | GSM4909287 | Human | Breast | IDC | 2.18e-10 | -4.95e-01 | 0.2057 |
91689 | SMDT1 | GSM4909288 | Human | Breast | IDC | 5.50e-03 | -3.82e-01 | 0.0988 |
91689 | SMDT1 | GSM4909293 | Human | Breast | IDC | 3.23e-06 | -2.31e-01 | 0.1581 |
91689 | SMDT1 | GSM4909294 | Human | Breast | IDC | 3.41e-08 | -1.99e-01 | 0.2022 |
91689 | SMDT1 | GSM4909296 | Human | Breast | IDC | 3.70e-14 | -7.89e-02 | 0.1524 |
91689 | SMDT1 | GSM4909297 | Human | Breast | IDC | 8.37e-26 | -1.34e-01 | 0.1517 |
91689 | SMDT1 | GSM4909311 | Human | Breast | IDC | 1.76e-50 | -3.88e-01 | 0.1534 |
91689 | SMDT1 | GSM4909312 | Human | Breast | IDC | 2.40e-22 | -3.37e-01 | 0.1552 |
91689 | SMDT1 | GSM4909313 | Human | Breast | IDC | 1.72e-04 | 1.16e-01 | 0.0391 |
91689 | SMDT1 | GSM4909315 | Human | Breast | IDC | 4.51e-07 | -3.35e-01 | 0.21 |
91689 | SMDT1 | GSM4909319 | Human | Breast | IDC | 4.71e-72 | -2.31e-01 | 0.1563 |
91689 | SMDT1 | GSM4909320 | Human | Breast | IDC | 1.39e-04 | -2.39e-01 | 0.1575 |
91689 | SMDT1 | GSM4909321 | Human | Breast | IDC | 1.30e-26 | -3.26e-01 | 0.1559 |
91689 | SMDT1 | brca2 | Human | Breast | Precancer | 3.21e-03 | -9.12e-02 | -0.024 |
91689 | SMDT1 | brca3 | Human | Breast | Precancer | 8.09e-06 | -2.31e-01 | -0.0263 |
91689 | SMDT1 | M2 | Human | Breast | IDC | 4.25e-02 | -2.23e-01 | 0.21 |
91689 | SMDT1 | NCCBC14 | Human | Breast | DCIS | 1.39e-12 | -3.27e-01 | 0.2021 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Stomach | WIM | ![]() |
Stomach | SIM | ![]() |
Liver | NAFLD | ![]() |
Liver | Cirrhotic | ![]() |
Liver | HCC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00068398 | Breast | Precancer | mitochondrial transport | 45/1080 | 254/18723 | 1.37e-11 | 1.88e-09 | 45 |
GO:19905427 | Breast | Precancer | mitochondrial transmembrane transport | 22/1080 | 102/18723 | 6.38e-08 | 3.80e-06 | 22 |
GO:0072503 | Breast | Precancer | cellular divalent inorganic cation homeostasis | 42/1080 | 486/18723 | 5.91e-03 | 4.21e-02 | 42 |
GO:000683913 | Breast | IDC | mitochondrial transport | 51/1434 | 254/18723 | 1.54e-10 | 1.83e-08 | 51 |
GO:199054214 | Breast | IDC | mitochondrial transmembrane transport | 25/1434 | 102/18723 | 1.39e-07 | 7.74e-06 | 25 |
GO:000683923 | Breast | DCIS | mitochondrial transport | 51/1390 | 254/18723 | 5.04e-11 | 6.79e-09 | 51 |
GO:199054222 | Breast | DCIS | mitochondrial transmembrane transport | 25/1390 | 102/18723 | 7.63e-08 | 4.45e-06 | 25 |
GO:00068399 | Cervix | CC | mitochondrial transport | 60/2311 | 254/18723 | 4.21e-07 | 1.67e-05 | 60 |
GO:19905428 | Cervix | CC | mitochondrial transmembrane transport | 26/2311 | 102/18723 | 2.10e-04 | 2.39e-03 | 26 |
GO:000683914 | Cervix | HSIL_HPV | mitochondrial transport | 22/737 | 254/18723 | 4.72e-04 | 6.90e-03 | 22 |
GO:199054215 | Cervix | HSIL_HPV | mitochondrial transmembrane transport | 12/737 | 102/18723 | 6.67e-04 | 9.08e-03 | 12 |
GO:0006839 | Colorectum | AD | mitochondrial transport | 102/3918 | 254/18723 | 1.87e-12 | 3.08e-10 | 102 |
GO:1990542 | Colorectum | AD | mitochondrial transmembrane transport | 47/3918 | 102/18723 | 1.09e-08 | 6.52e-07 | 47 |
GO:0051560 | Colorectum | AD | mitochondrial calcium ion homeostasis | 13/3918 | 26/18723 | 9.41e-04 | 8.92e-03 | 13 |
GO:0036444 | Colorectum | AD | calcium import into the mitochondrion | 8/3918 | 14/18723 | 3.23e-03 | 2.38e-02 | 8 |
GO:0006851 | Colorectum | AD | mitochondrial calcium ion transmembrane transport | 10/3918 | 20/18723 | 3.67e-03 | 2.60e-02 | 10 |
GO:00068391 | Colorectum | SER | mitochondrial transport | 87/2897 | 254/18723 | 7.91e-14 | 3.03e-11 | 87 |
GO:19905421 | Colorectum | SER | mitochondrial transmembrane transport | 42/2897 | 102/18723 | 3.65e-10 | 4.77e-08 | 42 |
GO:00068511 | Colorectum | SER | mitochondrial calcium ion transmembrane transport | 10/2897 | 20/18723 | 3.20e-04 | 5.15e-03 | 10 |
GO:00364441 | Colorectum | SER | calcium import into the mitochondrion | 8/2897 | 14/18723 | 4.06e-04 | 6.07e-03 | 8 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SMDT1 | insertion | Frame_Shift_Ins | novel | c.319_320insGCCCTCCTAGT | p.Asp107GlyfsTer63 | p.D107Gfs*63 | Q9H4I9 | protein_coding | TCGA-B6-A0RE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
SMDT1 | insertion | Nonsense_Mutation | novel | c.321_322insTGGTGCACCCGATTGCCTGTAGGGATTTAAAG | p.Ter108TrpfsTer10 | p.*108Wfs*10 | Q9H4I9 | protein_coding | TCGA-B6-A0RE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
SMDT1 | SNV | Missense_Mutation | novel | c.137N>T | p.Arg46Met | p.R46M | Q9H4I9 | protein_coding | deleterious(0.02) | probably_damaging(0.983) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SMDT1 | SNV | Missense_Mutation | rs139230313 | c.206G>A | p.Arg69His | p.R69H | Q9H4I9 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SMDT1 | SNV | Missense_Mutation | novel | c.292N>G | p.Phe98Val | p.F98V | Q9H4I9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-66-2785-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SMDT1 | SNV | Missense_Mutation | novel | c.188N>C | p.Met63Thr | p.M63T | Q9H4I9 | protein_coding | tolerated(0.85) | benign(0.047) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SMDT1 | SNV | Missense_Mutation | novel | c.34N>T | p.Ala12Ser | p.A12S | Q9H4I9 | protein_coding | tolerated(0.28) | benign(0.036) | TCGA-CG-5723-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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