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Gene: SMAGP |
Gene summary for SMAGP |
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Gene information | Species | Human | Gene symbol | SMAGP | Gene ID | 57228 |
Gene name | small cell adhesion glycoprotein | |
Gene Alias | hSMAGP | |
Cytomap | 12q13.13 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q0VAQ4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57228 | SMAGP | A015-C-203 | Human | Colorectum | FAP | 7.42e-15 | -2.16e-01 | -0.1294 |
57228 | SMAGP | A015-C-204 | Human | Colorectum | FAP | 2.75e-03 | -2.18e-01 | -0.0228 |
57228 | SMAGP | A002-C-201 | Human | Colorectum | FAP | 9.78e-04 | -1.51e-01 | 0.0324 |
57228 | SMAGP | A002-C-203 | Human | Colorectum | FAP | 4.08e-02 | -1.20e-01 | 0.2786 |
57228 | SMAGP | A001-C-119 | Human | Colorectum | FAP | 2.15e-02 | -2.57e-01 | -0.1557 |
57228 | SMAGP | A001-C-108 | Human | Colorectum | FAP | 1.36e-10 | -2.25e-01 | -0.0272 |
57228 | SMAGP | A002-C-205 | Human | Colorectum | FAP | 2.73e-12 | -3.55e-01 | -0.1236 |
57228 | SMAGP | A001-C-104 | Human | Colorectum | FAP | 1.26e-05 | -2.24e-01 | 0.0184 |
57228 | SMAGP | A015-C-006 | Human | Colorectum | FAP | 3.14e-07 | -2.07e-01 | -0.0994 |
57228 | SMAGP | A015-C-106 | Human | Colorectum | FAP | 3.65e-08 | -1.94e-01 | -0.0511 |
57228 | SMAGP | A002-C-114 | Human | Colorectum | FAP | 1.15e-07 | -1.54e-01 | -0.1561 |
57228 | SMAGP | A015-C-104 | Human | Colorectum | FAP | 2.67e-16 | -2.83e-01 | -0.1899 |
57228 | SMAGP | A001-C-014 | Human | Colorectum | FAP | 1.12e-08 | -3.05e-01 | 0.0135 |
57228 | SMAGP | A002-C-016 | Human | Colorectum | FAP | 1.12e-09 | -2.25e-01 | 0.0521 |
57228 | SMAGP | A015-C-002 | Human | Colorectum | FAP | 1.96e-05 | -3.72e-01 | -0.0763 |
57228 | SMAGP | A001-C-203 | Human | Colorectum | FAP | 1.06e-08 | -2.24e-01 | -0.0481 |
57228 | SMAGP | A002-C-116 | Human | Colorectum | FAP | 9.36e-17 | -2.83e-01 | -0.0452 |
57228 | SMAGP | A014-C-008 | Human | Colorectum | FAP | 9.83e-06 | -2.64e-01 | -0.191 |
57228 | SMAGP | A018-E-020 | Human | Colorectum | FAP | 1.94e-09 | -2.35e-01 | -0.2034 |
57228 | SMAGP | F034 | Human | Colorectum | FAP | 1.09e-11 | -2.01e-01 | -0.0665 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Stomach | WIM | ![]() |
Stomach | SIM | ![]() |
Liver | NAFLD | ![]() |
Liver | Cirrhotic | ![]() |
Liver | HCC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SMAGP | SNV | Missense_Mutation | c.277N>C | p.Glu93Gln | p.E93Q | Q0VAQ4 | protein_coding | tolerated(0.06) | probably_damaging(0.91) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
SMAGP | SNV | Missense_Mutation | novel | c.71N>T | p.Glu24Val | p.E24V | Q0VAQ4 | protein_coding | tolerated(0.12) | benign(0.136) | TCGA-AP-A1DO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SMAGP | SNV | Missense_Mutation | novel | c.202N>G | p.Thr68Ala | p.T68A | Q0VAQ4 | protein_coding | deleterious(0) | possibly_damaging(0.636) | TCGA-BG-A221-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SMAGP | SNV | Missense_Mutation | novel | c.98N>A | p.Ser33Asn | p.S33N | Q0VAQ4 | protein_coding | tolerated(0.82) | benign(0.026) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SMAGP | SNV | Missense_Mutation | novel | c.4N>G | p.Thr2Ala | p.T2A | Q0VAQ4 | protein_coding | tolerated_low_confidence(0.16) | benign(0.001) | TCGA-4R-AA8I-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SMAGP | SNV | Missense_Mutation | novel | c.223N>A | p.Glu75Lys | p.E75K | Q0VAQ4 | protein_coding | deleterious(0.01) | benign(0.298) | TCGA-78-8640-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SMAGP | SNV | Missense_Mutation | novel | c.22N>G | p.Pro8Ala | p.P8A | Q0VAQ4 | protein_coding | deleterious(0.05) | benign(0.003) | TCGA-85-A4CL-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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