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Gene: RPPH1 |
Gene summary for RPPH1 |
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Gene information | Species | Human | Gene symbol | RPPH1 | Gene ID | 85495 |
Gene name | ribonuclease P RNA component H1 | |
Gene Alias | H1RNA | |
Cytomap | 14q11.2 | |
Gene Type | ncRNA | GO ID | GO:0006139 | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
85495 | RPPH1 | P1T-E | Human | Esophagus | ESCC | 3.68e-13 | 7.49e-01 | 0.0875 |
85495 | RPPH1 | P4T-E | Human | Esophagus | ESCC | 1.77e-02 | 6.82e-02 | 0.1323 |
85495 | RPPH1 | P5T-E | Human | Esophagus | ESCC | 3.00e-10 | 2.82e-01 | 0.1327 |
85495 | RPPH1 | P8T-E | Human | Esophagus | ESCC | 8.12e-06 | 2.27e-01 | 0.0889 |
85495 | RPPH1 | P9T-E | Human | Esophagus | ESCC | 4.72e-26 | 6.48e-01 | 0.1131 |
85495 | RPPH1 | P10T-E | Human | Esophagus | ESCC | 8.23e-32 | 6.26e-01 | 0.116 |
85495 | RPPH1 | P12T-E | Human | Esophagus | ESCC | 3.31e-19 | 4.44e-01 | 0.1122 |
85495 | RPPH1 | P15T-E | Human | Esophagus | ESCC | 4.45e-14 | 4.31e-01 | 0.1149 |
85495 | RPPH1 | P16T-E | Human | Esophagus | ESCC | 2.65e-07 | 6.24e-02 | 0.1153 |
85495 | RPPH1 | P20T-E | Human | Esophagus | ESCC | 8.92e-03 | 6.86e-02 | 0.1124 |
85495 | RPPH1 | P22T-E | Human | Esophagus | ESCC | 1.09e-05 | 1.39e-01 | 0.1236 |
85495 | RPPH1 | P26T-E | Human | Esophagus | ESCC | 3.41e-02 | 1.10e-01 | 0.1276 |
85495 | RPPH1 | P27T-E | Human | Esophagus | ESCC | 1.45e-11 | 4.13e-01 | 0.1055 |
85495 | RPPH1 | P28T-E | Human | Esophagus | ESCC | 1.89e-13 | 2.12e-01 | 0.1149 |
85495 | RPPH1 | P37T-E | Human | Esophagus | ESCC | 7.22e-04 | 1.73e-01 | 0.1371 |
85495 | RPPH1 | P42T-E | Human | Esophagus | ESCC | 5.64e-05 | 1.17e-01 | 0.1175 |
85495 | RPPH1 | P47T-E | Human | Esophagus | ESCC | 9.34e-04 | 6.33e-02 | 0.1067 |
85495 | RPPH1 | P48T-E | Human | Esophagus | ESCC | 7.25e-11 | 3.69e-01 | 0.0959 |
85495 | RPPH1 | P49T-E | Human | Esophagus | ESCC | 2.37e-02 | 5.19e-01 | 0.1768 |
85495 | RPPH1 | P52T-E | Human | Esophagus | ESCC | 1.70e-06 | 2.18e-01 | 0.1555 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Stomach | WIM | ![]() |
Stomach | SIM | ![]() |
Liver | NAFLD | ![]() |
Liver | Cirrhotic | ![]() |
Liver | HCC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:00905013 | Esophagus | ESCC | RNA phosphodiester bond hydrolysis | 110/8552 | 152/18723 | 1.95e-11 | 6.81e-10 | 110 |
GO:00080333 | Esophagus | ESCC | tRNA processing | 92/8552 | 127/18723 | 7.83e-10 | 1.93e-08 | 92 |
GO:00063992 | Esophagus | ESCC | tRNA metabolic process | 122/8552 | 179/18723 | 9.03e-10 | 2.19e-08 | 122 |
GO:00903053 | Esophagus | ESCC | nucleic acid phosphodiester bond hydrolysis | 163/8552 | 261/18723 | 3.07e-08 | 5.73e-07 | 163 |
GO:00905023 | Esophagus | ESCC | RNA phosphodiester bond hydrolysis, endonucleolytic | 55/8552 | 82/18723 | 7.34e-05 | 5.51e-04 | 55 |
GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
GO:00905011 | Liver | HCC | RNA phosphodiester bond hydrolysis | 101/7958 | 152/18723 | 1.99e-09 | 5.63e-08 | 101 |
GO:0008033 | Liver | HCC | tRNA processing | 87/7958 | 127/18723 | 2.66e-09 | 7.23e-08 | 87 |
GO:0090305 | Liver | HCC | nucleic acid phosphodiester bond hydrolysis | 152/7958 | 261/18723 | 1.90e-07 | 3.46e-06 | 152 |
GO:0006399 | Liver | HCC | tRNA metabolic process | 108/7958 | 179/18723 | 1.07e-06 | 1.59e-05 | 108 |
GO:0090502 | Liver | HCC | RNA phosphodiester bond hydrolysis, endonucleolytic | 52/7958 | 82/18723 | 1.06e-04 | 9.08e-04 | 52 |
GO:003447013 | Prostate | Tumor | ncRNA processing | 94/3246 | 395/18723 | 6.02e-04 | 4.31e-03 | 94 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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