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Gene: RNF169 |
Gene summary for RNF169 |
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Gene information | Species | Human | Gene symbol | RNF169 | Gene ID | 254225 |
Gene name | ring finger protein 169 | |
Gene Alias | RNF169 | |
Cytomap | 11q13.4 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8NCN4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
254225 | RNF169 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.60e-15 | -5.07e-01 | 0.0155 |
254225 | RNF169 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.13e-06 | -4.76e-01 | -0.1808 |
254225 | RNF169 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.45e-06 | -4.46e-01 | -0.1088 |
254225 | RNF169 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.84e-02 | -2.84e-01 | -0.1954 |
254225 | RNF169 | HTA11_3361_2000001011 | Human | Colorectum | AD | 6.34e-07 | -5.21e-01 | -0.1207 |
254225 | RNF169 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.13e-05 | -4.01e-01 | -0.1464 |
254225 | RNF169 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.92e-04 | -3.75e-01 | -0.1001 |
254225 | RNF169 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.36e-04 | -3.76e-01 | -0.059 |
254225 | RNF169 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.24e-11 | -4.89e-01 | 0.096 |
254225 | RNF169 | HTA11_10711_2000001011 | Human | Colorectum | AD | 7.19e-06 | -4.59e-01 | 0.0338 |
254225 | RNF169 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.10e-10 | -4.61e-01 | 0.0674 |
254225 | RNF169 | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.66e-07 | -5.42e-01 | 0.0588 |
254225 | RNF169 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.27e-14 | -4.97e-01 | 0.294 |
254225 | RNF169 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.26e-03 | -4.26e-01 | 0.281 |
254225 | RNF169 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.50e-06 | -4.01e-01 | 0.3859 |
254225 | RNF169 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 8.20e-05 | -5.19e-01 | 0.2585 |
254225 | RNF169 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.43e-20 | -5.39e-01 | 0.3005 |
254225 | RNF169 | A001-C-207 | Human | Colorectum | FAP | 3.01e-07 | -3.02e-01 | 0.1278 |
254225 | RNF169 | A015-C-203 | Human | Colorectum | FAP | 4.13e-20 | -3.37e-01 | -0.1294 |
254225 | RNF169 | A015-C-204 | Human | Colorectum | FAP | 2.50e-05 | -2.60e-01 | -0.0228 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Stomach | WIM | ![]() |
Stomach | SIM | ![]() |
Liver | NAFLD | ![]() |
Liver | Cirrhotic | ![]() |
Liver | HCC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0051052 | Colorectum | AD | regulation of DNA metabolic process | 116/3918 | 359/18723 | 2.47e-07 | 1.00e-05 | 116 |
GO:2001020 | Colorectum | AD | regulation of response to DNA damage stimulus | 71/3918 | 219/18723 | 4.38e-05 | 7.65e-04 | 71 |
GO:0006282 | Colorectum | AD | regulation of DNA repair | 42/3918 | 130/18723 | 1.57e-03 | 1.32e-02 | 42 |
GO:00510521 | Colorectum | SER | regulation of DNA metabolic process | 83/2897 | 359/18723 | 8.03e-05 | 1.77e-03 | 83 |
GO:20010201 | Colorectum | SER | regulation of response to DNA damage stimulus | 49/2897 | 219/18723 | 4.24e-03 | 3.45e-02 | 49 |
GO:00510522 | Colorectum | MSS | regulation of DNA metabolic process | 108/3467 | 359/18723 | 5.86e-08 | 3.10e-06 | 108 |
GO:20010202 | Colorectum | MSS | regulation of response to DNA damage stimulus | 64/3467 | 219/18723 | 7.20e-05 | 1.21e-03 | 64 |
GO:00062821 | Colorectum | MSS | regulation of DNA repair | 38/3467 | 130/18723 | 1.93e-03 | 1.67e-02 | 38 |
GO:0006302 | Colorectum | MSS | double-strand break repair | 64/3467 | 251/18723 | 3.58e-03 | 2.65e-02 | 64 |
GO:00510524 | Colorectum | FAP | regulation of DNA metabolic process | 84/2622 | 359/18723 | 9.80e-07 | 4.38e-05 | 84 |
GO:20010204 | Colorectum | FAP | regulation of response to DNA damage stimulus | 51/2622 | 219/18723 | 1.40e-04 | 2.21e-03 | 51 |
GO:00062822 | Colorectum | FAP | regulation of DNA repair | 32/2622 | 130/18723 | 8.53e-04 | 8.79e-03 | 32 |
GO:00510525 | Colorectum | CRC | regulation of DNA metabolic process | 70/2078 | 359/18723 | 1.75e-06 | 8.92e-05 | 70 |
GO:20010205 | Colorectum | CRC | regulation of response to DNA damage stimulus | 45/2078 | 219/18723 | 3.13e-05 | 8.09e-04 | 45 |
GO:00062823 | Colorectum | CRC | regulation of DNA repair | 30/2078 | 130/18723 | 7.15e-05 | 1.52e-03 | 30 |
GO:005105215 | Esophagus | ESCC | regulation of DNA metabolic process | 232/8552 | 359/18723 | 2.40e-13 | 1.13e-11 | 232 |
GO:2001020110 | Esophagus | ESCC | regulation of response to DNA damage stimulus | 145/8552 | 219/18723 | 5.97e-10 | 1.50e-08 | 145 |
GO:00063024 | Esophagus | ESCC | double-strand break repair | 152/8552 | 251/18723 | 1.33e-06 | 1.62e-05 | 152 |
GO:00062826 | Esophagus | ESCC | regulation of DNA repair | 82/8552 | 130/18723 | 4.65e-05 | 3.66e-04 | 82 |
GO:200102112 | Esophagus | ESCC | negative regulation of response to DNA damage stimulus | 54/8552 | 81/18723 | 1.09e-04 | 7.64e-04 | 54 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RNF169 | SNV | Missense_Mutation | c.965C>G | p.Ser322Cys | p.S322C | Q8NCN4 | protein_coding | deleterious(0.01) | probably_damaging(0.956) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
RNF169 | SNV | Missense_Mutation | c.513N>G | p.Phe171Leu | p.F171L | Q8NCN4 | protein_coding | tolerated(0.07) | probably_damaging(0.956) | TCGA-E2-A10C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
RNF169 | SNV | Missense_Mutation | novel | c.2116N>A | p.Gly706Arg | p.G706R | Q8NCN4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
RNF169 | SNV | Missense_Mutation | rs779305012 | c.1238A>G | p.Asn413Ser | p.N413S | Q8NCN4 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AA-3680-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | folinic | PD |
RNF169 | SNV | Missense_Mutation | rs201694897 | c.2033N>A | p.Arg678His | p.R678H | Q8NCN4 | protein_coding | deleterious(0.04) | benign(0.048) | TCGA-AA-3821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RNF169 | SNV | Missense_Mutation | rs777393692 | c.790N>T | p.Arg264Cys | p.R264C | Q8NCN4 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AA-3869-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | PD |
RNF169 | SNV | Missense_Mutation | c.1569N>T | p.Glu523Asp | p.E523D | Q8NCN4 | protein_coding | tolerated(0.08) | benign(0.169) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
RNF169 | SNV | Missense_Mutation | c.1016N>T | p.Ser339Leu | p.S339L | Q8NCN4 | protein_coding | deleterious(0.03) | probably_damaging(0.994) | TCGA-AA-A01V-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
RNF169 | SNV | Missense_Mutation | rs375919416 | c.902C>T | p.Ala301Val | p.A301V | Q8NCN4 | protein_coding | tolerated(0.53) | benign(0.001) | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD |
RNF169 | SNV | Missense_Mutation | c.1129N>A | p.Glu377Lys | p.E377K | Q8NCN4 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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