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Gene: RBM28 |
Gene summary for RBM28 |
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Gene information | Species | Human | Gene symbol | RBM28 | Gene ID | 55131 |
Gene name | RNA binding motif protein 28 | |
Gene Alias | ANES | |
Cytomap | 7q32.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9NW13 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55131 | RBM28 | LZE4T | Human | Esophagus | ESCC | 1.65e-13 | 2.97e-01 | 0.0811 |
55131 | RBM28 | LZE20T | Human | Esophagus | ESCC | 1.31e-02 | 1.62e-01 | 0.0662 |
55131 | RBM28 | LZE22T | Human | Esophagus | ESCC | 3.07e-02 | 2.79e-01 | 0.068 |
55131 | RBM28 | LZE24T | Human | Esophagus | ESCC | 1.67e-09 | 3.35e-01 | 0.0596 |
55131 | RBM28 | P1T-E | Human | Esophagus | ESCC | 7.73e-10 | 3.75e-01 | 0.0875 |
55131 | RBM28 | P2T-E | Human | Esophagus | ESCC | 4.77e-11 | 2.60e-01 | 0.1177 |
55131 | RBM28 | P4T-E | Human | Esophagus | ESCC | 2.79e-21 | 5.97e-01 | 0.1323 |
55131 | RBM28 | P5T-E | Human | Esophagus | ESCC | 1.18e-18 | 4.41e-01 | 0.1327 |
55131 | RBM28 | P8T-E | Human | Esophagus | ESCC | 6.43e-17 | 3.16e-01 | 0.0889 |
55131 | RBM28 | P9T-E | Human | Esophagus | ESCC | 6.45e-15 | 3.40e-01 | 0.1131 |
55131 | RBM28 | P10T-E | Human | Esophagus | ESCC | 6.40e-34 | 5.88e-01 | 0.116 |
55131 | RBM28 | P11T-E | Human | Esophagus | ESCC | 6.94e-08 | 2.66e-01 | 0.1426 |
55131 | RBM28 | P12T-E | Human | Esophagus | ESCC | 8.44e-27 | 5.29e-01 | 0.1122 |
55131 | RBM28 | P15T-E | Human | Esophagus | ESCC | 2.97e-34 | 7.63e-01 | 0.1149 |
55131 | RBM28 | P16T-E | Human | Esophagus | ESCC | 9.20e-18 | 2.43e-01 | 0.1153 |
55131 | RBM28 | P17T-E | Human | Esophagus | ESCC | 4.87e-08 | 3.31e-01 | 0.1278 |
55131 | RBM28 | P19T-E | Human | Esophagus | ESCC | 8.34e-07 | 6.88e-01 | 0.1662 |
55131 | RBM28 | P20T-E | Human | Esophagus | ESCC | 1.95e-05 | 1.09e-01 | 0.1124 |
55131 | RBM28 | P21T-E | Human | Esophagus | ESCC | 4.90e-38 | 6.97e-01 | 0.1617 |
55131 | RBM28 | P22T-E | Human | Esophagus | ESCC | 5.23e-11 | 1.81e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Stomach | WIM | ![]() |
Stomach | SIM | ![]() |
Liver | NAFLD | ![]() |
Liver | Cirrhotic | ![]() |
Liver | HCC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
GO:000838022 | Liver | HCC | RNA splicing | 313/7958 | 434/18723 | 1.36e-36 | 1.73e-33 | 313 |
GO:000838020 | Oral cavity | OSCC | RNA splicing | 308/7305 | 434/18723 | 2.43e-42 | 7.70e-39 | 308 |
GO:0008380112 | Skin | cSCC | RNA splicing | 263/4864 | 434/18723 | 2.45e-53 | 5.13e-50 | 263 |
GO:0008380113 | Thyroid | PTC | RNA splicing | 273/5968 | 434/18723 | 4.44e-41 | 1.40e-37 | 273 |
GO:000838034 | Thyroid | ATC | RNA splicing | 270/6293 | 434/18723 | 7.50e-35 | 1.19e-31 | 270 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RBM28 | SNV | Missense_Mutation | c.41N>G | p.Ser14Trp | p.S14W | Q9NW13 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A8-A094-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RBM28 | SNV | Missense_Mutation | novel | c.2236N>G | p.Lys746Glu | p.K746E | Q9NW13 | protein_coding | tolerated(0.1) | benign(0.138) | TCGA-AC-A3W6-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
RBM28 | SNV | Missense_Mutation | c.754G>A | p.Glu252Lys | p.E252K | Q9NW13 | protein_coding | tolerated(0.21) | benign(0.018) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD | |
RBM28 | SNV | Missense_Mutation | c.776N>T | p.Ser259Leu | p.S259L | Q9NW13 | protein_coding | tolerated(0.1) | benign(0.001) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RBM28 | SNV | Missense_Mutation | rs145208220 | c.1355C>T | p.Thr452Met | p.T452M | Q9NW13 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-E9-A1RI-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | tamoxiphen | SD |
RBM28 | SNV | Missense_Mutation | novel | c.2252N>A | p.Ala751Glu | p.A751E | Q9NW13 | protein_coding | tolerated(0.8) | benign(0) | TCGA-UU-A93S-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
RBM28 | insertion | Frame_Shift_Ins | novel | c.1346_1347insC | p.Ala450CysfsTer13 | p.A450Cfs*13 | Q9NW13 | protein_coding | TCGA-A8-A09X-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
RBM28 | insertion | Nonsense_Mutation | novel | c.1345_1346insTCTTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGT | p.Arg449LeufsTer8 | p.R449Lfs*8 | Q9NW13 | protein_coding | TCGA-A8-A09X-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
RBM28 | insertion | Frame_Shift_Ins | novel | c.1688_1689insCCTCCACCTTCTGGGTTCAAGTGATTCTCTTGCC | p.Pro564LeufsTer34 | p.P564Lfs*34 | Q9NW13 | protein_coding | TCGA-BH-A0EB-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
RBM28 | SNV | Missense_Mutation | novel | c.650C>T | p.Ser217Leu | p.S217L | Q9NW13 | protein_coding | tolerated(0.67) | benign(0) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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