![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: R3HDM1 |
Gene summary for R3HDM1 |
![]() |
Gene information | Species | Human | Gene symbol | R3HDM1 | Gene ID | 23518 |
Gene name | R3H domain containing 1 | |
Gene Alias | R3HDM | |
Cytomap | 2q21.3 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q15032 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23518 | R3HDM1 | CCI_1 | Human | Cervix | CC | 5.26e-05 | 7.99e-01 | 0.528 |
23518 | R3HDM1 | CCI_2 | Human | Cervix | CC | 2.05e-07 | 9.88e-01 | 0.5249 |
23518 | R3HDM1 | CCI_3 | Human | Cervix | CC | 2.03e-12 | 8.49e-01 | 0.516 |
23518 | R3HDM1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.21e-08 | -2.90e-01 | 0.0155 |
23518 | R3HDM1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 2.77e-02 | -6.75e-01 | -0.1462 |
23518 | R3HDM1 | F007 | Human | Colorectum | FAP | 1.38e-03 | -3.64e-01 | 0.1176 |
23518 | R3HDM1 | A001-C-207 | Human | Colorectum | FAP | 1.56e-06 | -3.75e-01 | 0.1278 |
23518 | R3HDM1 | A015-C-203 | Human | Colorectum | FAP | 5.43e-38 | -6.11e-01 | -0.1294 |
23518 | R3HDM1 | A015-C-204 | Human | Colorectum | FAP | 8.94e-08 | -3.48e-01 | -0.0228 |
23518 | R3HDM1 | A014-C-040 | Human | Colorectum | FAP | 4.44e-06 | -5.33e-01 | -0.1184 |
23518 | R3HDM1 | A002-C-201 | Human | Colorectum | FAP | 1.27e-16 | -4.45e-01 | 0.0324 |
23518 | R3HDM1 | A001-C-119 | Human | Colorectum | FAP | 1.39e-11 | -5.31e-01 | -0.1557 |
23518 | R3HDM1 | A001-C-108 | Human | Colorectum | FAP | 5.43e-20 | -4.46e-01 | -0.0272 |
23518 | R3HDM1 | A002-C-205 | Human | Colorectum | FAP | 4.29e-23 | -4.46e-01 | -0.1236 |
23518 | R3HDM1 | A014-C-108 | Human | Colorectum | FAP | 1.82e-02 | -3.50e-01 | -0.124 |
23518 | R3HDM1 | A001-C-104 | Human | Colorectum | FAP | 4.58e-09 | -3.71e-01 | 0.0184 |
23518 | R3HDM1 | A015-C-005 | Human | Colorectum | FAP | 1.76e-07 | -3.36e-01 | -0.0336 |
23518 | R3HDM1 | A015-C-006 | Human | Colorectum | FAP | 3.20e-16 | -5.46e-01 | -0.0994 |
23518 | R3HDM1 | A015-C-106 | Human | Colorectum | FAP | 9.51e-19 | -3.87e-01 | -0.0511 |
23518 | R3HDM1 | A002-C-114 | Human | Colorectum | FAP | 3.65e-22 | -5.63e-01 | -0.1561 |
Page: 1 2 3 4 5 6 7 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Stomach | WIM | ![]() |
Stomach | SIM | ![]() |
Liver | NAFLD | ![]() |
Liver | Cirrhotic | ![]() |
Liver | HCC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
R3HDM1 | SNV | Missense_Mutation | c.522G>T | p.Leu174Phe | p.L174F | Q15032 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A2-A0YT-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | arimidex | SD | |
R3HDM1 | SNV | Missense_Mutation | c.503N>T | p.Arg168Ile | p.R168I | Q15032 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
R3HDM1 | SNV | Missense_Mutation | c.11N>T | p.Ser4Phe | p.S4F | Q15032 | protein_coding | deleterious(0) | possibly_damaging(0.603) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
R3HDM1 | insertion | Frame_Shift_Ins | novel | c.1461_1462insGAGCCAATGCTTTTATGTAGTAACTGCATGTTATGCAATGT | p.Asn488GlufsTer23 | p.N488Efs*23 | Q15032 | protein_coding | TCGA-A2-A0CP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
R3HDM1 | SNV | Missense_Mutation | rs778568401 | c.757C>T | p.Arg253Cys | p.R253C | Q15032 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
R3HDM1 | SNV | Missense_Mutation | c.1256G>A | p.Gly419Asp | p.G419D | Q15032 | protein_coding | deleterious(0.04) | probably_damaging(0.942) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
R3HDM1 | SNV | Missense_Mutation | c.577N>T | p.Pro193Ser | p.P193S | Q15032 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
R3HDM1 | SNV | Missense_Mutation | rs755222892 | c.239N>A | p.Arg80Gln | p.R80Q | Q15032 | protein_coding | deleterious(0) | benign(0.005) | TCGA-3L-AA1B-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
R3HDM1 | SNV | Missense_Mutation | rs747738172 | c.1318N>A | p.Ala440Thr | p.A440T | Q15032 | protein_coding | tolerated(0.6) | benign(0) | TCGA-A6-A565-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unspecific | 5FU | PD |
R3HDM1 | SNV | Missense_Mutation | c.409N>G | p.Leu137Val | p.L137V | Q15032 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR |
Page: 1 2 3 4 5 6 7 8 9 10 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |