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Gene: PYROXD1 |
Gene summary for PYROXD1 |
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Gene information | Species | Human | Gene symbol | PYROXD1 | Gene ID | 79912 |
Gene name | pyridine nucleotide-disulphide oxidoreductase domain 1 | |
Gene Alias | MFM8 | |
Cytomap | 12p12.1 | |
Gene Type | protein-coding | GO ID | GO:0006950 | UniProtAcc | Q8WU10 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79912 | PYROXD1 | LZE24T | Human | Esophagus | ESCC | 7.19e-07 | 2.12e-01 | 0.0596 |
79912 | PYROXD1 | P1T-E | Human | Esophagus | ESCC | 2.48e-05 | 2.73e-01 | 0.0875 |
79912 | PYROXD1 | P2T-E | Human | Esophagus | ESCC | 1.17e-18 | 3.60e-01 | 0.1177 |
79912 | PYROXD1 | P4T-E | Human | Esophagus | ESCC | 1.69e-11 | 3.06e-01 | 0.1323 |
79912 | PYROXD1 | P5T-E | Human | Esophagus | ESCC | 1.28e-05 | 1.54e-01 | 0.1327 |
79912 | PYROXD1 | P8T-E | Human | Esophagus | ESCC | 6.00e-10 | 1.69e-01 | 0.0889 |
79912 | PYROXD1 | P9T-E | Human | Esophagus | ESCC | 1.34e-05 | 1.16e-01 | 0.1131 |
79912 | PYROXD1 | P10T-E | Human | Esophagus | ESCC | 5.62e-12 | 2.64e-01 | 0.116 |
79912 | PYROXD1 | P12T-E | Human | Esophagus | ESCC | 4.71e-16 | 4.03e-01 | 0.1122 |
79912 | PYROXD1 | P15T-E | Human | Esophagus | ESCC | 1.93e-04 | 8.86e-02 | 0.1149 |
79912 | PYROXD1 | P16T-E | Human | Esophagus | ESCC | 3.37e-38 | 6.81e-01 | 0.1153 |
79912 | PYROXD1 | P20T-E | Human | Esophagus | ESCC | 6.60e-10 | 3.34e-01 | 0.1124 |
79912 | PYROXD1 | P21T-E | Human | Esophagus | ESCC | 1.01e-12 | 2.66e-01 | 0.1617 |
79912 | PYROXD1 | P22T-E | Human | Esophagus | ESCC | 2.73e-11 | 2.55e-01 | 0.1236 |
79912 | PYROXD1 | P23T-E | Human | Esophagus | ESCC | 3.36e-08 | 3.16e-01 | 0.108 |
79912 | PYROXD1 | P24T-E | Human | Esophagus | ESCC | 6.01e-07 | 2.27e-01 | 0.1287 |
79912 | PYROXD1 | P26T-E | Human | Esophagus | ESCC | 9.90e-10 | 2.07e-01 | 0.1276 |
79912 | PYROXD1 | P27T-E | Human | Esophagus | ESCC | 5.55e-18 | 3.18e-01 | 0.1055 |
79912 | PYROXD1 | P28T-E | Human | Esophagus | ESCC | 4.07e-05 | 8.79e-02 | 0.1149 |
79912 | PYROXD1 | P31T-E | Human | Esophagus | ESCC | 1.05e-03 | 1.13e-01 | 0.1251 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Stomach | WIM | ![]() |
Stomach | SIM | ![]() |
Liver | NAFLD | ![]() |
Liver | Cirrhotic | ![]() |
Liver | HCC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006979111 | Esophagus | ESCC | response to oxidative stress | 303/8552 | 446/18723 | 7.15e-22 | 1.30e-19 | 303 |
GO:0062197111 | Esophagus | ESCC | cellular response to chemical stress | 234/8552 | 337/18723 | 5.37e-19 | 5.97e-17 | 234 |
GO:0034599111 | Esophagus | ESCC | cellular response to oxidative stress | 197/8552 | 288/18723 | 3.76e-15 | 2.15e-13 | 197 |
GO:000697920 | Oral cavity | OSCC | response to oxidative stress | 273/7305 | 446/18723 | 8.35e-22 | 1.65e-19 | 273 |
GO:006219720 | Oral cavity | OSCC | cellular response to chemical stress | 204/7305 | 337/18723 | 6.89e-16 | 5.19e-14 | 204 |
GO:003459920 | Oral cavity | OSCC | cellular response to oxidative stress | 173/7305 | 288/18723 | 2.90e-13 | 1.43e-11 | 173 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PYROXD1 | SNV | Missense_Mutation | c.1459N>C | p.Asp487His | p.D487H | Q8WU10 | protein_coding | deleterious(0.02) | possibly_damaging(0.572) | TCGA-A2-A04P-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxol | PD | |
PYROXD1 | SNV | Missense_Mutation | c.1004G>C | p.Gly335Ala | p.G335A | Q8WU10 | protein_coding | tolerated(0.77) | benign(0.07) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
PYROXD1 | SNV | Missense_Mutation | rs568225764 | c.1178N>T | p.Ala393Val | p.A393V | Q8WU10 | protein_coding | tolerated(0.26) | benign(0.003) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PYROXD1 | SNV | Missense_Mutation | c.1368G>A | p.Met456Ile | p.M456I | Q8WU10 | protein_coding | deleterious(0.03) | benign(0.042) | TCGA-C5-A1MK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD | |
PYROXD1 | SNV | Missense_Mutation | c.1259T>C | p.Val420Ala | p.V420A | Q8WU10 | protein_coding | deleterious(0) | benign(0.285) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
PYROXD1 | SNV | Missense_Mutation | rs757948948 | c.1238N>C | p.Lys413Thr | p.K413T | Q8WU10 | protein_coding | tolerated(0.15) | benign(0.061) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
PYROXD1 | SNV | Missense_Mutation | c.446N>T | p.Arg149Ile | p.R149I | Q8WU10 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
PYROXD1 | SNV | Missense_Mutation | c.1111C>A | p.Gln371Lys | p.Q371K | Q8WU10 | protein_coding | deleterious(0.03) | benign(0.017) | TCGA-AG-3592-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PYROXD1 | SNV | Missense_Mutation | c.820N>G | p.Ile274Val | p.I274V | Q8WU10 | protein_coding | tolerated(0.29) | benign(0.034) | TCGA-AG-A016-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | SD | |
PYROXD1 | SNV | Missense_Mutation | novel | c.11N>G | p.Ala4Gly | p.A4G | Q8WU10 | protein_coding | tolerated_low_confidence(0.12) | benign(0.001) | TCGA-CI-6621-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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