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Gene: PVRL1 |
Gene summary for PVRL1 |
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Gene information | Species | Human | Gene symbol | PVRL1 | Gene ID | 5818 |
Gene name | nectin cell adhesion molecule 1 | |
Gene Alias | CD111 | |
Cytomap | 11q23.3 | |
Gene Type | protein-coding | GO ID | GO:0000041 | UniProtAcc | Q15223 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5818 | PVRL1 | P1T-E | Human | Esophagus | ESCC | 5.75e-15 | 5.41e-01 | 0.0875 |
5818 | PVRL1 | P2T-E | Human | Esophagus | ESCC | 8.08e-19 | 2.64e-01 | 0.1177 |
5818 | PVRL1 | P4T-E | Human | Esophagus | ESCC | 1.99e-47 | 1.07e+00 | 0.1323 |
5818 | PVRL1 | P5T-E | Human | Esophagus | ESCC | 5.95e-29 | 5.47e-01 | 0.1327 |
5818 | PVRL1 | P8T-E | Human | Esophagus | ESCC | 4.30e-10 | 1.86e-01 | 0.0889 |
5818 | PVRL1 | P9T-E | Human | Esophagus | ESCC | 4.49e-33 | 7.29e-01 | 0.1131 |
5818 | PVRL1 | P10T-E | Human | Esophagus | ESCC | 4.18e-52 | 8.49e-01 | 0.116 |
5818 | PVRL1 | P11T-E | Human | Esophagus | ESCC | 2.94e-14 | 6.19e-01 | 0.1426 |
5818 | PVRL1 | P12T-E | Human | Esophagus | ESCC | 2.28e-35 | 6.20e-01 | 0.1122 |
5818 | PVRL1 | P15T-E | Human | Esophagus | ESCC | 6.38e-34 | 6.46e-01 | 0.1149 |
5818 | PVRL1 | P16T-E | Human | Esophagus | ESCC | 4.12e-11 | 2.53e-01 | 0.1153 |
5818 | PVRL1 | P17T-E | Human | Esophagus | ESCC | 1.29e-08 | 3.29e-01 | 0.1278 |
5818 | PVRL1 | P19T-E | Human | Esophagus | ESCC | 6.53e-04 | 3.45e-01 | 0.1662 |
5818 | PVRL1 | P20T-E | Human | Esophagus | ESCC | 1.16e-15 | 3.30e-01 | 0.1124 |
5818 | PVRL1 | P21T-E | Human | Esophagus | ESCC | 2.49e-44 | 8.75e-01 | 0.1617 |
5818 | PVRL1 | P22T-E | Human | Esophagus | ESCC | 4.19e-25 | 4.00e-01 | 0.1236 |
5818 | PVRL1 | P23T-E | Human | Esophagus | ESCC | 6.38e-25 | 4.97e-01 | 0.108 |
5818 | PVRL1 | P24T-E | Human | Esophagus | ESCC | 2.06e-08 | 2.08e-01 | 0.1287 |
5818 | PVRL1 | P26T-E | Human | Esophagus | ESCC | 8.96e-45 | 7.30e-01 | 0.1276 |
5818 | PVRL1 | P27T-E | Human | Esophagus | ESCC | 1.02e-31 | 5.09e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Stomach | WIM | ![]() |
Stomach | SIM | ![]() |
Liver | NAFLD | ![]() |
Liver | Cirrhotic | ![]() |
Liver | HCC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0452020 | Cervix | CC | Adherens junction | 33/1267 | 93/8465 | 6.99e-07 | 7.31e-06 | 4.32e-06 | 33 |
hsa045147 | Cervix | CC | Cell adhesion molecules | 36/1267 | 157/8465 | 4.94e-03 | 1.67e-02 | 9.86e-03 | 36 |
hsa04520110 | Cervix | CC | Adherens junction | 33/1267 | 93/8465 | 6.99e-07 | 7.31e-06 | 4.32e-06 | 33 |
hsa0451412 | Cervix | CC | Cell adhesion molecules | 36/1267 | 157/8465 | 4.94e-03 | 1.67e-02 | 9.86e-03 | 36 |
hsa04520 | Colorectum | AD | Adherens junction | 50/2092 | 93/8465 | 1.52e-09 | 2.83e-08 | 1.81e-08 | 50 |
hsa045201 | Colorectum | AD | Adherens junction | 50/2092 | 93/8465 | 1.52e-09 | 2.83e-08 | 1.81e-08 | 50 |
hsa045204 | Colorectum | MSS | Adherens junction | 42/1875 | 93/8465 | 6.18e-07 | 9.01e-06 | 5.52e-06 | 42 |
hsa045205 | Colorectum | MSS | Adherens junction | 42/1875 | 93/8465 | 6.18e-07 | 9.01e-06 | 5.52e-06 | 42 |
hsa045206 | Colorectum | MSI-H | Adherens junction | 22/797 | 93/8465 | 3.71e-05 | 5.47e-04 | 4.58e-04 | 22 |
hsa045207 | Colorectum | MSI-H | Adherens junction | 22/797 | 93/8465 | 3.71e-05 | 5.47e-04 | 4.58e-04 | 22 |
hsa045208 | Colorectum | FAP | Adherens junction | 45/1404 | 93/8465 | 8.66e-13 | 2.89e-10 | 1.76e-10 | 45 |
hsa045209 | Colorectum | FAP | Adherens junction | 45/1404 | 93/8465 | 8.66e-13 | 2.89e-10 | 1.76e-10 | 45 |
hsa0452042 | Liver | HCC | Adherens junction | 68/4020 | 93/8465 | 3.99e-07 | 4.46e-06 | 2.48e-06 | 68 |
hsa0452052 | Liver | HCC | Adherens junction | 68/4020 | 93/8465 | 3.99e-07 | 4.46e-06 | 2.48e-06 | 68 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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