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Gene: PVALB |
Gene summary for PVALB |
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Gene information | Species | Human | Gene symbol | PVALB | Gene ID | 5816 |
Gene name | parvalbumin | |
Gene Alias | D22S749 | |
Cytomap | 22q12.3 | |
Gene Type | protein-coding | GO ID | GO:0007275 | UniProtAcc | A0A024R1K9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5816 | PVALB | GSM4909297 | Human | Breast | IDC | 1.70e-06 | 4.16e-01 | 0.1517 |
5816 | PVALB | GSM4909306 | Human | Breast | IDC | 9.51e-42 | 8.84e-01 | 0.1564 |
5816 | PVALB | GSM4909319 | Human | Breast | IDC | 7.81e-24 | 1.06e+00 | 0.1563 |
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Tissue | Expression Dynamics | Abbreviation |
Breast | ![]() | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ | ||
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Stomach | WIM | ![]() |
Stomach | SIM | ![]() |
Liver | NAFLD | ![]() |
Liver | Cirrhotic | ![]() |
Liver | HCC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PVALB | SNV | Missense_Mutation | c.280N>A | p.Gly94Arg | p.G94R | P20472 | protein_coding | deleterious(0.01) | probably_damaging(0.995) | TCGA-A8-A0A9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD | |
PVALB | insertion | Frame_Shift_Ins | novel | c.86dupA | p.Phe30ValfsTer14 | p.F30Vfs*14 | P20472 | protein_coding | TCGA-AC-A8OP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
PVALB | SNV | Missense_Mutation | c.76N>A | p.Asp26Asn | p.D26N | P20472 | protein_coding | tolerated(0.95) | benign(0.086) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
PVALB | SNV | Missense_Mutation | novel | c.256N>A | p.Leu86Met | p.L86M | P20472 | protein_coding | tolerated(0.06) | possibly_damaging(0.559) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PVALB | SNV | Missense_Mutation | novel | c.309C>A | p.Phe103Leu | p.F103L | P20472 | protein_coding | deleterious(0) | possibly_damaging(0.801) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PVALB | SNV | Missense_Mutation | c.166N>G | p.Ser56Gly | p.S56G | P20472 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PVALB | SNV | Missense_Mutation | novel | c.229N>T | p.Asp77Tyr | p.D77Y | P20472 | protein_coding | deleterious(0.03) | probably_damaging(0.954) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
PVALB | SNV | Missense_Mutation | c.154N>C | p.Asp52His | p.D52H | P20472 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-55-7994-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | CR | |
PVALB | SNV | Missense_Mutation | c.296N>T | p.Gly99Val | p.G99V | P20472 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-78-7158-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD | |
PVALB | SNV | Missense_Mutation | c.253N>T | p.Met85Leu | p.M85L | P20472 | protein_coding | deleterious(0.02) | benign(0.005) | TCGA-MP-A5C7-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5816 | PVALB | NA | SALINE | SODIUM CHLORIDE | 9133585 |
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