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Gene: PIP4P2 |
Gene summary for PIP4P2 |
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Gene information | Species | Human | Gene symbol | PIP4P2 | Gene ID | 55529 |
Gene name | phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 | |
Gene Alias | TMEM55A | |
Cytomap | 8q21.3 | |
Gene Type | protein-coding | GO ID | GO:0006629 | UniProtAcc | Q8N4L2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55529 | PIP4P2 | S014 | Human | Liver | HCC | 5.56e-27 | 9.86e-01 | 0.2254 |
55529 | PIP4P2 | S015 | Human | Liver | HCC | 1.50e-27 | 9.35e-01 | 0.2375 |
55529 | PIP4P2 | S016 | Human | Liver | HCC | 1.77e-35 | 1.00e+00 | 0.2243 |
55529 | PIP4P2 | S027 | Human | Liver | HCC | 8.01e-14 | 1.04e+00 | 0.2446 |
55529 | PIP4P2 | S028 | Human | Liver | HCC | 1.51e-28 | 1.19e+00 | 0.2503 |
55529 | PIP4P2 | S029 | Human | Liver | HCC | 6.58e-35 | 1.48e+00 | 0.2581 |
55529 | PIP4P2 | PTC05 | Human | Thyroid | PTC | 2.31e-02 | 1.52e-01 | 0.2065 |
55529 | PIP4P2 | PTC06 | Human | Thyroid | PTC | 3.49e-02 | 1.09e-01 | 0.2057 |
55529 | PIP4P2 | PTC07 | Human | Thyroid | PTC | 5.43e-04 | 1.25e-01 | 0.2044 |
55529 | PIP4P2 | ATC12 | Human | Thyroid | ATC | 5.96e-08 | 1.90e-01 | 0.34 |
55529 | PIP4P2 | ATC13 | Human | Thyroid | ATC | 7.27e-33 | 6.61e-01 | 0.34 |
55529 | PIP4P2 | ATC1 | Human | Thyroid | ATC | 8.56e-03 | 1.56e-01 | 0.2878 |
55529 | PIP4P2 | ATC2 | Human | Thyroid | ATC | 2.49e-06 | 3.68e-01 | 0.34 |
55529 | PIP4P2 | ATC4 | Human | Thyroid | ATC | 4.82e-12 | 2.72e-01 | 0.34 |
55529 | PIP4P2 | ATC5 | Human | Thyroid | ATC | 9.31e-45 | 7.20e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Stomach | WIM | ![]() |
Stomach | SIM | ![]() |
Liver | NAFLD | ![]() |
Liver | Cirrhotic | ![]() |
Liver | HCC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00066444 | Liver | HCC | phospholipid metabolic process | 214/7958 | 383/18723 | 7.25e-08 | 1.48e-06 | 214 |
GO:001631121 | Liver | HCC | dephosphorylation | 230/7958 | 417/18723 | 1.00e-07 | 1.96e-06 | 230 |
GO:004648611 | Liver | HCC | glycerolipid metabolic process | 215/7958 | 392/18723 | 4.54e-07 | 7.49e-06 | 215 |
GO:003025821 | Liver | HCC | lipid modification | 123/7958 | 212/18723 | 3.50e-06 | 4.58e-05 | 123 |
GO:00066504 | Liver | HCC | glycerophospholipid metabolic process | 168/7958 | 306/18723 | 7.27e-06 | 8.62e-05 | 168 |
GO:001631116 | Thyroid | PTC | dephosphorylation | 174/5968 | 417/18723 | 1.20e-05 | 1.31e-04 | 174 |
GO:00510518 | Thyroid | PTC | negative regulation of transport | 176/5968 | 470/18723 | 5.44e-03 | 2.49e-02 | 176 |
GO:0050765 | Thyroid | PTC | negative regulation of phagocytosis | 13/5968 | 23/18723 | 1.25e-02 | 4.88e-02 | 13 |
GO:001631117 | Thyroid | ATC | dephosphorylation | 179/6293 | 417/18723 | 3.88e-05 | 3.15e-04 | 179 |
GO:005105114 | Thyroid | ATC | negative regulation of transport | 183/6293 | 470/18723 | 8.12e-03 | 3.13e-02 | 183 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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