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Gene: OGFRL1 |
Gene summary for OGFRL1 |
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Gene information | Species | Human | Gene symbol | OGFRL1 | Gene ID | 79627 |
Gene name | opioid growth factor receptor like 1 | |
Gene Alias | dJ331H24.1 | |
Cytomap | 6q13 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q5TC84 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79627 | OGFRL1 | LZE21T | Human | Esophagus | ESCC | 2.70e-02 | 2.83e-02 | 0.0655 |
79627 | OGFRL1 | P2T-E | Human | Esophagus | ESCC | 6.06e-12 | 1.31e-02 | 0.1177 |
79627 | OGFRL1 | P4T-E | Human | Esophagus | ESCC | 3.73e-14 | 1.67e-01 | 0.1323 |
79627 | OGFRL1 | P5T-E | Human | Esophagus | ESCC | 2.40e-11 | 1.37e-02 | 0.1327 |
79627 | OGFRL1 | P8T-E | Human | Esophagus | ESCC | 2.04e-13 | 3.63e-02 | 0.0889 |
79627 | OGFRL1 | P9T-E | Human | Esophagus | ESCC | 5.31e-07 | 6.42e-03 | 0.1131 |
79627 | OGFRL1 | P10T-E | Human | Esophagus | ESCC | 1.17e-02 | -8.70e-02 | 0.116 |
79627 | OGFRL1 | P12T-E | Human | Esophagus | ESCC | 2.29e-06 | -6.32e-02 | 0.1122 |
79627 | OGFRL1 | P15T-E | Human | Esophagus | ESCC | 1.11e-07 | 1.24e-01 | 0.1149 |
79627 | OGFRL1 | P16T-E | Human | Esophagus | ESCC | 1.06e-12 | 3.21e-01 | 0.1153 |
79627 | OGFRL1 | P20T-E | Human | Esophagus | ESCC | 4.91e-02 | 5.40e-02 | 0.1124 |
79627 | OGFRL1 | P21T-E | Human | Esophagus | ESCC | 3.94e-02 | -5.33e-02 | 0.1617 |
79627 | OGFRL1 | P22T-E | Human | Esophagus | ESCC | 2.18e-09 | 1.97e-02 | 0.1236 |
79627 | OGFRL1 | P23T-E | Human | Esophagus | ESCC | 1.18e-06 | 4.72e-02 | 0.108 |
79627 | OGFRL1 | P24T-E | Human | Esophagus | ESCC | 5.45e-04 | -6.25e-02 | 0.1287 |
79627 | OGFRL1 | P26T-E | Human | Esophagus | ESCC | 1.82e-16 | 2.62e-01 | 0.1276 |
79627 | OGFRL1 | P27T-E | Human | Esophagus | ESCC | 2.68e-06 | 4.47e-02 | 0.1055 |
79627 | OGFRL1 | P28T-E | Human | Esophagus | ESCC | 1.07e-14 | 4.17e-01 | 0.1149 |
79627 | OGFRL1 | P30T-E | Human | Esophagus | ESCC | 1.36e-11 | 5.26e-01 | 0.137 |
79627 | OGFRL1 | P31T-E | Human | Esophagus | ESCC | 2.09e-10 | 5.94e-02 | 0.1251 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Stomach | WIM | ![]() |
Stomach | SIM | ![]() |
Liver | NAFLD | ![]() |
Liver | Cirrhotic | ![]() |
Liver | HCC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
OGFRL1 | SNV | Missense_Mutation | novel | c.845N>G | p.Tyr282Cys | p.Y282C | Q5TC84 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AC-A62X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
OGFRL1 | SNV | Missense_Mutation | c.893N>A | p.Arg298Gln | p.R298Q | Q5TC84 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-BH-A1EV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
OGFRL1 | SNV | Missense_Mutation | novel | c.769C>T | p.Pro257Ser | p.P257S | Q5TC84 | protein_coding | deleterious(0) | probably_damaging(0.935) | TCGA-EA-A5ZE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
OGFRL1 | SNV | Missense_Mutation | rs370124520 | c.338N>A | p.Arg113Gln | p.R113Q | Q5TC84 | protein_coding | tolerated(0.07) | possibly_damaging(0.723) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
OGFRL1 | SNV | Missense_Mutation | c.924N>T | p.Glu308Asp | p.E308D | Q5TC84 | protein_coding | tolerated(0.8) | benign(0.03) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
OGFRL1 | SNV | Missense_Mutation | novel | c.317N>G | p.Tyr106Cys | p.Y106C | Q5TC84 | protein_coding | deleterious(0) | probably_damaging(0.956) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
OGFRL1 | SNV | Missense_Mutation | c.308N>A | p.Arg103Gln | p.R103Q | Q5TC84 | protein_coding | deleterious(0.02) | possibly_damaging(0.773) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
OGFRL1 | SNV | Missense_Mutation | c.649N>T | p.Ala217Ser | p.A217S | Q5TC84 | protein_coding | tolerated(0.09) | benign(0.149) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
OGFRL1 | SNV | Missense_Mutation | c.811N>T | p.Thr271Ser | p.T271S | Q5TC84 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
OGFRL1 | SNV | Missense_Mutation | c.415N>A | p.Glu139Lys | p.E139K | Q5TC84 | protein_coding | deleterious(0.01) | probably_damaging(0.963) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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