Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/NUBPL_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/NUBPL_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/NUBPL_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/NUBPL_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/NUBPL_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010257 | Colorectum | AD | NADH dehydrogenase complex assembly | 34/3918 | 57/18723 | 2.15e-10 | 1.89e-08 | 34 |
GO:0032981 | Colorectum | AD | mitochondrial respiratory chain complex I assembly | 34/3918 | 57/18723 | 2.15e-10 | 1.89e-08 | 34 |
GO:0033108 | Colorectum | AD | mitochondrial respiratory chain complex assembly | 46/3918 | 93/18723 | 8.95e-10 | 6.91e-08 | 46 |
GO:0006790 | Colorectum | AD | sulfur compound metabolic process | 101/3918 | 339/18723 | 6.46e-05 | 1.07e-03 | 101 |
GO:0070584 | Colorectum | AD | mitochondrion morphogenesis | 12/3918 | 21/18723 | 3.02e-04 | 3.62e-03 | 12 |
GO:00102572 | Colorectum | MSS | NADH dehydrogenase complex assembly | 33/3467 | 57/18723 | 4.07e-11 | 4.86e-09 | 33 |
GO:00329812 | Colorectum | MSS | mitochondrial respiratory chain complex I assembly | 33/3467 | 57/18723 | 4.07e-11 | 4.86e-09 | 33 |
GO:00331082 | Colorectum | MSS | mitochondrial respiratory chain complex assembly | 44/3467 | 93/18723 | 2.17e-10 | 2.09e-08 | 44 |
GO:00705842 | Colorectum | MSS | mitochondrion morphogenesis | 12/3467 | 21/18723 | 8.83e-05 | 1.41e-03 | 12 |
GO:00067902 | Colorectum | MSS | sulfur compound metabolic process | 85/3467 | 339/18723 | 1.52e-03 | 1.39e-02 | 85 |
GO:00705843 | Colorectum | FAP | mitochondrion morphogenesis | 9/2622 | 21/18723 | 1.22e-03 | 1.14e-02 | 9 |
GO:00705844 | Colorectum | CRC | mitochondrion morphogenesis | 8/2078 | 21/18723 | 1.22e-03 | 1.38e-02 | 8 |
GO:0033108110 | Esophagus | ESCC | mitochondrial respiratory chain complex assembly | 83/8552 | 93/18723 | 9.56e-19 | 1.05e-16 | 83 |
GO:0010257110 | Esophagus | ESCC | NADH dehydrogenase complex assembly | 50/8552 | 57/18723 | 3.78e-11 | 1.24e-09 | 50 |
GO:0032981110 | Esophagus | ESCC | mitochondrial respiratory chain complex I assembly | 50/8552 | 57/18723 | 3.78e-11 | 1.24e-09 | 50 |
GO:00067906 | Esophagus | ESCC | sulfur compound metabolic process | 201/8552 | 339/18723 | 2.64e-07 | 3.94e-06 | 201 |
GO:00705848 | Esophagus | ESCC | mitochondrion morphogenesis | 18/8552 | 21/18723 | 1.81e-04 | 1.16e-03 | 18 |
GO:001622611 | Esophagus | ESCC | iron-sulfur cluster assembly | 21/8552 | 26/18723 | 2.69e-04 | 1.63e-03 | 21 |
GO:003116311 | Esophagus | ESCC | metallo-sulfur cluster assembly | 21/8552 | 26/18723 | 2.69e-04 | 1.63e-03 | 21 |
GO:00067904 | Liver | NAFLD | sulfur compound metabolic process | 58/1882 | 339/18723 | 3.79e-05 | 9.38e-04 | 58 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NUBPL | insertion | In_Frame_Ins | novel | c.676_677insACCATGTTA | p.Arg226delinsHisHisValSer | p.R226delinsHHVS | Q8TB37 | protein_coding | | | TCGA-A7-A0CJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
NUBPL | insertion | In_Frame_Ins | novel | c.678_679insCAGGCTGGTCTTGAACTCCTGACCCCA | p.Arg226_Arg227insGlnAlaGlyLeuGluLeuLeuThrPro | p.R226_R227insQAGLELLTP | Q8TB37 | protein_coding | | | TCGA-A7-A0CJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
NUBPL | SNV | Missense_Mutation | rs781341998 | c.488C>T | p.Ser163Leu | p.S163L | Q8TB37 | protein_coding | deleterious(0) | benign(0.232) | TCGA-C5-A1BL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
NUBPL | SNV | Missense_Mutation | | c.316N>A | p.Val106Met | p.V106M | Q8TB37 | protein_coding | deleterious(0) | possibly_damaging(0.549) | TCGA-C5-A7UC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
NUBPL | SNV | Missense_Mutation | novel | c.717N>C | p.Met239Ile | p.M239I | Q8TB37 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
NUBPL | SNV | Missense_Mutation | | c.613N>A | p.Val205Met | p.V205M | Q8TB37 | protein_coding | deleterious(0.01) | probably_damaging(0.973) | TCGA-LP-A4AV-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
NUBPL | SNV | Missense_Mutation | | c.805N>C | p.Glu269Gln | p.E269Q | Q8TB37 | protein_coding | tolerated(0.15) | benign(0.003) | TCGA-Q1-A5R2-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PR |
NUBPL | SNV | Missense_Mutation | novel | c.680G>C | p.Arg227Thr | p.R227T | Q8TB37 | protein_coding | deleterious(0) | benign(0.003) | TCGA-UC-A7PI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
NUBPL | SNV | Missense_Mutation | rs749762773 | c.640N>A | p.Ala214Thr | p.A214T | Q8TB37 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-A6-2680-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NUBPL | SNV | Missense_Mutation | rs776389264 | c.281C>T | p.Ala94Val | p.A94V | Q8TB37 | protein_coding | tolerated(0.06) | benign(0.391) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |