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Gene: MRPL14 |
Gene summary for MRPL14 |
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Gene information | Species | Human | Gene symbol | MRPL14 | Gene ID | 64928 |
Gene name | mitochondrial ribosomal protein L14 | |
Gene Alias | L14mt | |
Cytomap | 6p21.1 | |
Gene Type | protein-coding | GO ID | GO:0006412 | UniProtAcc | A0A024RD78 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64928 | MRPL14 | GSM4909281 | Human | Breast | IDC | 1.64e-40 | 7.62e-01 | 0.21 |
64928 | MRPL14 | GSM4909282 | Human | Breast | IDC | 1.30e-08 | 4.47e-01 | -0.0288 |
64928 | MRPL14 | GSM4909285 | Human | Breast | IDC | 2.23e-11 | 4.46e-01 | 0.21 |
64928 | MRPL14 | GSM4909286 | Human | Breast | IDC | 1.39e-02 | 6.78e-02 | 0.1081 |
64928 | MRPL14 | GSM4909288 | Human | Breast | IDC | 8.08e-07 | 7.48e-02 | 0.0988 |
64928 | MRPL14 | GSM4909289 | Human | Breast | IDC | 1.74e-02 | 3.71e-01 | 0.1064 |
64928 | MRPL14 | GSM4909290 | Human | Breast | IDC | 1.06e-02 | 2.80e-01 | 0.2096 |
64928 | MRPL14 | GSM4909291 | Human | Breast | IDC | 1.54e-05 | 3.39e-01 | 0.1753 |
64928 | MRPL14 | GSM4909293 | Human | Breast | IDC | 1.34e-02 | 1.32e-01 | 0.1581 |
64928 | MRPL14 | GSM4909294 | Human | Breast | IDC | 1.32e-03 | -4.80e-04 | 0.2022 |
64928 | MRPL14 | GSM4909296 | Human | Breast | IDC | 3.03e-09 | 9.55e-02 | 0.1524 |
64928 | MRPL14 | GSM4909297 | Human | Breast | IDC | 6.81e-19 | -1.81e-01 | 0.1517 |
64928 | MRPL14 | GSM4909301 | Human | Breast | IDC | 1.17e-03 | 2.58e-01 | 0.1577 |
64928 | MRPL14 | GSM4909302 | Human | Breast | IDC | 5.64e-03 | -1.84e-01 | 0.1545 |
64928 | MRPL14 | GSM4909307 | Human | Breast | IDC | 5.25e-09 | 4.38e-01 | 0.1569 |
64928 | MRPL14 | GSM4909308 | Human | Breast | IDC | 1.75e-15 | 4.70e-01 | 0.158 |
64928 | MRPL14 | GSM4909309 | Human | Breast | IDC | 1.80e-04 | 9.40e-02 | 0.0483 |
64928 | MRPL14 | GSM4909311 | Human | Breast | IDC | 5.68e-37 | -1.23e-01 | 0.1534 |
64928 | MRPL14 | GSM4909312 | Human | Breast | IDC | 5.24e-16 | 1.80e-01 | 0.1552 |
64928 | MRPL14 | GSM4909313 | Human | Breast | IDC | 1.02e-06 | -1.09e-01 | 0.0391 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Stomach | WIM | ![]() |
Stomach | SIM | ![]() |
Liver | NAFLD | ![]() |
Liver | Cirrhotic | ![]() |
Liver | HCC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0301018 | Breast | Precancer | Ribosome | 80/684 | 167/8465 | 7.33e-44 | 2.32e-41 | 1.77e-41 | 80 |
hsa0301019 | Breast | Precancer | Ribosome | 80/684 | 167/8465 | 7.33e-44 | 2.32e-41 | 1.77e-41 | 80 |
hsa0301024 | Breast | IDC | Ribosome | 83/867 | 167/8465 | 6.07e-39 | 9.87e-37 | 7.38e-37 | 83 |
hsa0301034 | Breast | IDC | Ribosome | 83/867 | 167/8465 | 6.07e-39 | 9.87e-37 | 7.38e-37 | 83 |
hsa0301044 | Breast | DCIS | Ribosome | 82/846 | 167/8465 | 8.69e-39 | 1.40e-36 | 1.03e-36 | 82 |
hsa0301054 | Breast | DCIS | Ribosome | 82/846 | 167/8465 | 8.69e-39 | 1.40e-36 | 1.03e-36 | 82 |
hsa0301026 | Endometrium | AEH | Ribosome | 89/1197 | 167/8465 | 1.88e-33 | 6.09e-31 | 4.46e-31 | 89 |
hsa03010112 | Endometrium | AEH | Ribosome | 89/1197 | 167/8465 | 1.88e-33 | 6.09e-31 | 4.46e-31 | 89 |
hsa0301027 | Endometrium | EEC | Ribosome | 89/1237 | 167/8465 | 2.55e-32 | 8.39e-30 | 6.26e-30 | 89 |
hsa0301036 | Endometrium | EEC | Ribosome | 89/1237 | 167/8465 | 2.55e-32 | 8.39e-30 | 6.26e-30 | 89 |
hsa03010211 | Esophagus | ESCC | Ribosome | 129/4205 | 167/8465 | 1.43e-13 | 3.43e-12 | 1.75e-12 | 129 |
hsa03010310 | Esophagus | ESCC | Ribosome | 129/4205 | 167/8465 | 1.43e-13 | 3.43e-12 | 1.75e-12 | 129 |
hsa0301022 | Liver | Cirrhotic | Ribosome | 127/2530 | 167/8465 | 2.12e-35 | 7.06e-33 | 4.35e-33 | 127 |
hsa0301032 | Liver | Cirrhotic | Ribosome | 127/2530 | 167/8465 | 2.12e-35 | 7.06e-33 | 4.35e-33 | 127 |
hsa0301042 | Liver | HCC | Ribosome | 128/4020 | 167/8465 | 7.32e-15 | 2.23e-13 | 1.24e-13 | 128 |
hsa0301052 | Liver | HCC | Ribosome | 128/4020 | 167/8465 | 7.32e-15 | 2.23e-13 | 1.24e-13 | 128 |
hsa0301030 | Oral cavity | OSCC | Ribosome | 128/3704 | 167/8465 | 2.42e-18 | 1.62e-16 | 8.25e-17 | 128 |
hsa03010114 | Oral cavity | OSCC | Ribosome | 128/3704 | 167/8465 | 2.42e-18 | 1.62e-16 | 8.25e-17 | 128 |
hsa03010210 | Oral cavity | LP | Ribosome | 127/2418 | 167/8465 | 1.22e-37 | 4.05e-35 | 2.61e-35 | 127 |
hsa0301038 | Oral cavity | LP | Ribosome | 127/2418 | 167/8465 | 1.22e-37 | 4.05e-35 | 2.61e-35 | 127 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MRPL14 | SNV | Missense_Mutation | c.216G>C | p.Gln72His | p.Q72H | Q6P1L8 | protein_coding | deleterious(0) | benign(0.183) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
MRPL14 | insertion | Nonsense_Mutation | novel | c.206_207insCCCTTCACACTGGGTAACAGTGTAGTATCCTGTGAGAGAATAAATG | p.Gly70ProfsTer8 | p.G70Pfs*8 | Q6P1L8 | protein_coding | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
MRPL14 | SNV | Missense_Mutation | rs531985422 | c.116N>A | p.Arg39Gln | p.R39Q | Q6P1L8 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
MRPL14 | SNV | Missense_Mutation | rs751402548 | c.383G>A | p.Arg128His | p.R128H | Q6P1L8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AJ-A2QO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MRPL14 | SNV | Missense_Mutation | novel | c.343N>A | p.Val115Met | p.V115M | Q6P1L8 | protein_coding | tolerated(0.07) | benign(0.127) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
MRPL14 | SNV | Missense_Mutation | novel | c.205G>A | p.Val69Met | p.V69M | Q6P1L8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MRPL14 | SNV | Missense_Mutation | novel | c.232N>G | p.Lys78Glu | p.K78E | Q6P1L8 | protein_coding | tolerated(0.07) | benign(0.028) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MRPL14 | SNV | Missense_Mutation | novel | c.181N>C | p.Tyr61His | p.Y61H | Q6P1L8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
MRPL14 | SNV | Missense_Mutation | novel | c.33N>A | p.Phe11Leu | p.F11L | Q6P1L8 | protein_coding | tolerated_low_confidence(1) | benign(0) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MRPL14 | SNV | Missense_Mutation | novel | c.49N>A | p.Val17Met | p.V17M | Q6P1L8 | protein_coding | tolerated(0.17) | benign(0) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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