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Gene: MIR122HG |
Gene summary for MIR122HG |
Gene summary. |
Gene information | Species | Human | Gene symbol | MIR122HG | Gene ID | 112441433 |
Gene name | MIR122 host gene | |
Gene Alias | MIR122HG | |
Cytomap | 18q21.31 | |
Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
112441433 | MIR122HG | NAFLD1 | Human | Liver | NAFLD | 3.58e-13 | 1.24e+00 | -0.04 |
112441433 | MIR122HG | S41 | Human | Liver | Cirrhotic | 2.09e-04 | 6.49e-01 | -0.0343 |
112441433 | MIR122HG | S43 | Human | Liver | Cirrhotic | 4.91e-06 | -1.93e-01 | -0.0187 |
112441433 | MIR122HG | HCC1_Meng | Human | Liver | HCC | 2.32e-08 | -2.44e-01 | 0.0246 |
112441433 | MIR122HG | HCC2_Meng | Human | Liver | HCC | 5.02e-08 | -2.44e-01 | 0.0107 |
112441433 | MIR122HG | cirrhotic1 | Human | Liver | Cirrhotic | 5.02e-08 | -2.44e-01 | 0.0202 |
112441433 | MIR122HG | cirrhotic2 | Human | Liver | Cirrhotic | 1.08e-07 | -2.44e-01 | 0.0201 |
112441433 | MIR122HG | cirrhotic3 | Human | Liver | Cirrhotic | 2.78e-03 | -2.44e-01 | 0.0215 |
112441433 | MIR122HG | Pt13.a | Human | Liver | HCC | 1.08e-07 | -2.44e-01 | 0.021 |
112441433 | MIR122HG | Pt13.b | Human | Liver | HCC | 1.85e-02 | -2.44e-01 | 0.0251 |
112441433 | MIR122HG | Pt14.d | Human | Liver | HCC | 2.32e-08 | -2.44e-01 | 0.0143 |
112441433 | MIR122HG | S028 | Human | Liver | HCC | 2.58e-06 | 6.52e-01 | 0.2503 |
112441433 | MIR122HG | S029 | Human | Liver | HCC | 1.87e-08 | 7.00e-01 | 0.2581 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Liver | HCC: Hepatocellular carcinoma | |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Stomach | WIM | |
Stomach | SIM | |
Liver | NAFLD | |
Liver | Cirrhotic | |
Liver | HCC |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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