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Gene: MARVELD1 |
Gene summary for MARVELD1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | MARVELD1 | Gene ID | 83742 |
Gene name | MARVEL domain containing 1 | |
Gene Alias | GB14 | |
Cytomap | 10q24.2 | |
Gene Type | protein-coding | GO ID | GO:0007049 | UniProtAcc | Q9BSK0 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83742 | MARVELD1 | LZE24T | Human | Esophagus | ESCC | 4.47e-03 | 1.21e-01 | 0.0596 |
83742 | MARVELD1 | P2T-E | Human | Esophagus | ESCC | 5.77e-12 | 2.39e-01 | 0.1177 |
83742 | MARVELD1 | P4T-E | Human | Esophagus | ESCC | 8.33e-21 | 3.93e-01 | 0.1323 |
83742 | MARVELD1 | P5T-E | Human | Esophagus | ESCC | 8.32e-03 | 8.31e-02 | 0.1327 |
83742 | MARVELD1 | P8T-E | Human | Esophagus | ESCC | 1.29e-04 | 5.71e-02 | 0.0889 |
83742 | MARVELD1 | P9T-E | Human | Esophagus | ESCC | 1.41e-03 | 4.44e-02 | 0.1131 |
83742 | MARVELD1 | P10T-E | Human | Esophagus | ESCC | 8.25e-11 | 6.59e-02 | 0.116 |
83742 | MARVELD1 | P11T-E | Human | Esophagus | ESCC | 1.69e-09 | 6.43e-01 | 0.1426 |
83742 | MARVELD1 | P12T-E | Human | Esophagus | ESCC | 2.76e-12 | 2.21e-01 | 0.1122 |
83742 | MARVELD1 | P15T-E | Human | Esophagus | ESCC | 2.71e-05 | 1.42e-01 | 0.1149 |
83742 | MARVELD1 | P16T-E | Human | Esophagus | ESCC | 1.53e-14 | 2.59e-01 | 0.1153 |
83742 | MARVELD1 | P19T-E | Human | Esophagus | ESCC | 1.87e-02 | 1.12e-01 | 0.1662 |
83742 | MARVELD1 | P20T-E | Human | Esophagus | ESCC | 7.05e-06 | 2.91e-02 | 0.1124 |
83742 | MARVELD1 | P21T-E | Human | Esophagus | ESCC | 7.64e-12 | 2.21e-01 | 0.1617 |
83742 | MARVELD1 | P22T-E | Human | Esophagus | ESCC | 1.64e-15 | 1.33e-01 | 0.1236 |
83742 | MARVELD1 | P23T-E | Human | Esophagus | ESCC | 1.81e-09 | 3.66e-02 | 0.108 |
83742 | MARVELD1 | P24T-E | Human | Esophagus | ESCC | 7.86e-06 | 8.07e-02 | 0.1287 |
83742 | MARVELD1 | P26T-E | Human | Esophagus | ESCC | 5.32e-12 | 1.41e-01 | 0.1276 |
83742 | MARVELD1 | P27T-E | Human | Esophagus | ESCC | 2.50e-09 | 1.23e-01 | 0.1055 |
83742 | MARVELD1 | P28T-E | Human | Esophagus | ESCC | 6.62e-13 | 2.60e-01 | 0.1149 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Stomach | WIM | |
Stomach | SIM | |
Liver | NAFLD | |
Liver | Cirrhotic | |
Liver | HCC |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00425524 | Esophagus | ESCC | myelination | 85/8552 | 134/18723 | 2.51e-05 | 2.13e-04 | 85 |
GO:00072724 | Esophagus | ESCC | ensheathment of neurons | 86/8552 | 136/18723 | 2.68e-05 | 2.24e-04 | 86 |
GO:00083664 | Esophagus | ESCC | axon ensheathment | 86/8552 | 136/18723 | 2.68e-05 | 2.24e-04 | 86 |
GO:00072723 | Oral cavity | OSCC | ensheathment of neurons | 72/7305 | 136/18723 | 6.59e-04 | 3.70e-03 | 72 |
GO:00083663 | Oral cavity | OSCC | axon ensheathment | 72/7305 | 136/18723 | 6.59e-04 | 3.70e-03 | 72 |
GO:00425523 | Oral cavity | OSCC | myelination | 71/7305 | 134/18723 | 6.93e-04 | 3.86e-03 | 71 |
GO:004255221 | Skin | cSCC | myelination | 51/4864 | 134/18723 | 1.37e-03 | 8.70e-03 | 51 |
GO:000727221 | Skin | cSCC | ensheathment of neurons | 51/4864 | 136/18723 | 1.99e-03 | 1.19e-02 | 51 |
GO:000836621 | Skin | cSCC | axon ensheathment | 51/4864 | 136/18723 | 1.99e-03 | 1.19e-02 | 51 |
GO:00425526 | Thyroid | ATC | myelination | 62/6293 | 134/18723 | 1.54e-03 | 7.84e-03 | 62 |
GO:00072726 | Thyroid | ATC | ensheathment of neurons | 62/6293 | 136/18723 | 2.39e-03 | 1.11e-02 | 62 |
GO:00083666 | Thyroid | ATC | axon ensheathment | 62/6293 | 136/18723 | 2.39e-03 | 1.11e-02 | 62 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MARVELD1 | SNV | Missense_Mutation | novel | c.223N>T | p.Leu75Phe | p.L75F | Q9BSK0 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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