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Gene: MANEA |
Gene summary for MANEA |
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Gene information | Species | Human | Gene symbol | MANEA | Gene ID | 79694 |
Gene name | mannosidase endo-alpha | |
Gene Alias | ENDO | |
Cytomap | 6q16.1 | |
Gene Type | protein-coding | GO ID | GO:0000139 | UniProtAcc | Q5SRI9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79694 | MANEA | HCC1_Meng | Human | Liver | HCC | 2.81e-47 | 1.25e-01 | 0.0246 |
79694 | MANEA | HCC2_Meng | Human | Liver | HCC | 9.16e-11 | 1.11e-01 | 0.0107 |
79694 | MANEA | HCC1 | Human | Liver | HCC | 2.77e-06 | 2.78e+00 | 0.5336 |
79694 | MANEA | HCC2 | Human | Liver | HCC | 2.29e-06 | 2.01e+00 | 0.5341 |
79694 | MANEA | S014 | Human | Liver | HCC | 2.91e-15 | 4.84e-01 | 0.2254 |
79694 | MANEA | S015 | Human | Liver | HCC | 6.29e-14 | 6.27e-01 | 0.2375 |
79694 | MANEA | S016 | Human | Liver | HCC | 6.57e-27 | 7.00e-01 | 0.2243 |
79694 | MANEA | S027 | Human | Liver | HCC | 7.08e-05 | 5.27e-01 | 0.2446 |
79694 | MANEA | S028 | Human | Liver | HCC | 1.98e-14 | 4.66e-01 | 0.2503 |
79694 | MANEA | S029 | Human | Liver | HCC | 1.72e-14 | 5.16e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease | ||
Prostate | ![]() | BPH: Benign Prostatic Hyperplasia |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Stomach | WIM | ![]() |
Stomach | SIM | ![]() |
Liver | NAFLD | ![]() |
Liver | Cirrhotic | ![]() |
Liver | HCC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MANEA | SNV | Missense_Mutation | rs772610838 | c.1165N>A | p.Ala389Thr | p.A389T | Q5SRI9 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-A8-A076-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
MANEA | SNV | Missense_Mutation | c.782C>T | p.Ala261Val | p.A261V | Q5SRI9 | protein_coding | tolerated(0.54) | benign(0) | TCGA-AR-A24Z-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
MANEA | SNV | Missense_Mutation | novel | c.452N>T | p.Gly151Val | p.G151V | Q5SRI9 | protein_coding | deleterious(0) | probably_damaging(0.963) | TCGA-S3-AA10-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | CR |
MANEA | insertion | Nonsense_Mutation | novel | c.541_542insAATAG | p.Ile181LysfsTer2 | p.I181Kfs*2 | Q5SRI9 | protein_coding | TCGA-A8-A097-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
MANEA | insertion | Nonsense_Mutation | novel | c.541_542insAATAG | p.Ile181LysfsTer2 | p.I181Kfs*2 | Q5SRI9 | protein_coding | TCGA-AQ-A04H-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD | ||
MANEA | SNV | Missense_Mutation | c.208N>A | p.Glu70Lys | p.E70K | Q5SRI9 | protein_coding | tolerated(0.77) | benign(0.048) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR | |
MANEA | SNV | Missense_Mutation | novel | c.742N>T | p.His248Tyr | p.H248Y | Q5SRI9 | protein_coding | deleterious(0.02) | probably_damaging(0.998) | TCGA-MY-A913-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MANEA | SNV | Missense_Mutation | c.79N>C | p.Lys27Gln | p.K27Q | Q5SRI9 | protein_coding | deleterious(0.01) | probably_damaging(0.986) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MANEA | SNV | Missense_Mutation | novel | c.54N>G | p.Phe18Leu | p.F18L | Q5SRI9 | protein_coding | tolerated(0.38) | benign(0) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MANEA | SNV | Missense_Mutation | novel | c.528N>A | p.Met176Ile | p.M176I | Q5SRI9 | protein_coding | tolerated(0.92) | benign(0.001) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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