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Gene: LONRF1 |
Gene summary for LONRF1 |
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Gene information | Species | Human | Gene symbol | LONRF1 | Gene ID | 91694 |
Gene name | LON peptidase N-terminal domain and ring finger 1 | |
Gene Alias | RNF191 | |
Cytomap | 8p23.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q17RB8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
91694 | LONRF1 | LZE24T | Human | Esophagus | ESCC | 3.54e-04 | 9.09e-03 | 0.0596 |
91694 | LONRF1 | P1T-E | Human | Esophagus | ESCC | 2.09e-02 | 5.59e-02 | 0.0875 |
91694 | LONRF1 | P2T-E | Human | Esophagus | ESCC | 6.63e-28 | 5.63e-01 | 0.1177 |
91694 | LONRF1 | P4T-E | Human | Esophagus | ESCC | 7.26e-12 | 2.79e-01 | 0.1323 |
91694 | LONRF1 | P5T-E | Human | Esophagus | ESCC | 1.26e-06 | -6.08e-02 | 0.1327 |
91694 | LONRF1 | P8T-E | Human | Esophagus | ESCC | 5.06e-11 | -1.27e-03 | 0.0889 |
91694 | LONRF1 | P9T-E | Human | Esophagus | ESCC | 9.73e-12 | 1.61e-01 | 0.1131 |
91694 | LONRF1 | P10T-E | Human | Esophagus | ESCC | 7.20e-16 | 2.36e-01 | 0.116 |
91694 | LONRF1 | P12T-E | Human | Esophagus | ESCC | 5.44e-05 | -4.84e-02 | 0.1122 |
91694 | LONRF1 | P15T-E | Human | Esophagus | ESCC | 2.34e-05 | -3.66e-02 | 0.1149 |
91694 | LONRF1 | P16T-E | Human | Esophagus | ESCC | 5.27e-11 | 1.11e-01 | 0.1153 |
91694 | LONRF1 | P20T-E | Human | Esophagus | ESCC | 1.55e-09 | 5.46e-02 | 0.1124 |
91694 | LONRF1 | P21T-E | Human | Esophagus | ESCC | 2.17e-08 | -5.45e-02 | 0.1617 |
91694 | LONRF1 | P22T-E | Human | Esophagus | ESCC | 4.18e-14 | 6.22e-02 | 0.1236 |
91694 | LONRF1 | P23T-E | Human | Esophagus | ESCC | 3.66e-05 | 8.77e-02 | 0.108 |
91694 | LONRF1 | P24T-E | Human | Esophagus | ESCC | 5.20e-14 | 5.10e-03 | 0.1287 |
91694 | LONRF1 | P26T-E | Human | Esophagus | ESCC | 5.65e-05 | 9.55e-03 | 0.1276 |
91694 | LONRF1 | P27T-E | Human | Esophagus | ESCC | 1.75e-06 | 1.58e-02 | 0.1055 |
91694 | LONRF1 | P28T-E | Human | Esophagus | ESCC | 1.51e-28 | 6.36e-01 | 0.1149 |
91694 | LONRF1 | P30T-E | Human | Esophagus | ESCC | 2.26e-24 | 7.31e-01 | 0.137 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Stomach | WIM | ![]() |
Stomach | SIM | ![]() |
Liver | NAFLD | ![]() |
Liver | Cirrhotic | ![]() |
Liver | HCC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LONRF1 | SNV | Missense_Mutation | c.865C>A | p.Leu289Ile | p.L289I | Q17RB8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A2-A25A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cytoxan | SD | |
LONRF1 | SNV | Missense_Mutation | rs758592289 | c.901C>T | p.Leu301Phe | p.L301F | Q17RB8 | protein_coding | tolerated(0.18) | benign(0.066) | TCGA-A8-A09G-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
LONRF1 | SNV | Missense_Mutation | c.1358N>T | p.Thr453Ile | p.T453I | Q17RB8 | protein_coding | tolerated(0.12) | benign(0) | TCGA-B6-A0IJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
LONRF1 | SNV | Missense_Mutation | c.1834N>A | p.Asp612Asn | p.D612N | Q17RB8 | protein_coding | deleterious(0.03) | possibly_damaging(0.627) | TCGA-BH-A0W7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | |
LONRF1 | SNV | Missense_Mutation | novel | c.1564N>C | p.Glu522Gln | p.E522Q | Q17RB8 | protein_coding | tolerated(0.22) | possibly_damaging(0.463) | TCGA-C8-A1HM-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | CR |
LONRF1 | insertion | Frame_Shift_Ins | novel | c.2045_2046insAGTGGCTATAATTCTTAGG | p.Leu683ValfsTer9 | p.L683Vfs*9 | Q17RB8 | protein_coding | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
LONRF1 | deletion | Frame_Shift_Del | novel | c.1785delT | p.Arg596GlufsTer55 | p.R596Efs*55 | Q17RB8 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
LONRF1 | SNV | Missense_Mutation | novel | c.1948N>A | p.Leu650Ile | p.L650I | Q17RB8 | protein_coding | tolerated(0.26) | probably_damaging(0.951) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
LONRF1 | SNV | Missense_Mutation | c.1449N>C | p.Met483Ile | p.M483I | Q17RB8 | protein_coding | deleterious(0.04) | benign(0.444) | TCGA-EK-A2IP-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
LONRF1 | SNV | Missense_Mutation | c.1431N>A | p.Phe477Leu | p.F477L | Q17RB8 | protein_coding | tolerated(0.64) | benign(0.139) | TCGA-IR-A3LI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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