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Gene: LINC01003 |
Gene summary for LINC01003 |
Gene summary. |
Gene information | Species | Human | Gene symbol | LINC01003 | Gene ID | 100128822 |
Gene name | long intergenic non-protein coding RNA 1003 | |
Gene Alias | LINC01003 | |
Cytomap | 7q36.1 | |
Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
100128822 | LINC01003 | LZE24T | Human | Esophagus | ESCC | 1.70e-04 | 1.44e-01 | 0.0596 |
100128822 | LINC01003 | P1T-E | Human | Esophagus | ESCC | 2.81e-05 | 3.46e-01 | 0.0875 |
100128822 | LINC01003 | P2T-E | Human | Esophagus | ESCC | 5.14e-12 | 1.70e-01 | 0.1177 |
100128822 | LINC01003 | P4T-E | Human | Esophagus | ESCC | 5.62e-10 | 3.32e-01 | 0.1323 |
100128822 | LINC01003 | P5T-E | Human | Esophagus | ESCC | 1.03e-17 | 3.18e-01 | 0.1327 |
100128822 | LINC01003 | P8T-E | Human | Esophagus | ESCC | 4.84e-05 | 1.25e-01 | 0.0889 |
100128822 | LINC01003 | P9T-E | Human | Esophagus | ESCC | 6.60e-06 | 1.23e-01 | 0.1131 |
100128822 | LINC01003 | P10T-E | Human | Esophagus | ESCC | 1.66e-08 | 1.72e-01 | 0.116 |
100128822 | LINC01003 | P12T-E | Human | Esophagus | ESCC | 4.75e-06 | 1.47e-01 | 0.1122 |
100128822 | LINC01003 | P15T-E | Human | Esophagus | ESCC | 2.22e-05 | 1.21e-01 | 0.1149 |
100128822 | LINC01003 | P16T-E | Human | Esophagus | ESCC | 1.26e-03 | 6.24e-02 | 0.1153 |
100128822 | LINC01003 | P20T-E | Human | Esophagus | ESCC | 4.64e-02 | 8.86e-02 | 0.1124 |
100128822 | LINC01003 | P21T-E | Human | Esophagus | ESCC | 2.88e-05 | 1.14e-01 | 0.1617 |
100128822 | LINC01003 | P22T-E | Human | Esophagus | ESCC | 3.03e-02 | 8.29e-02 | 0.1236 |
100128822 | LINC01003 | P23T-E | Human | Esophagus | ESCC | 2.28e-13 | 3.50e-01 | 0.108 |
100128822 | LINC01003 | P24T-E | Human | Esophagus | ESCC | 2.07e-06 | 1.27e-01 | 0.1287 |
100128822 | LINC01003 | P26T-E | Human | Esophagus | ESCC | 1.21e-16 | 3.18e-01 | 0.1276 |
100128822 | LINC01003 | P27T-E | Human | Esophagus | ESCC | 1.80e-03 | 1.06e-01 | 0.1055 |
100128822 | LINC01003 | P28T-E | Human | Esophagus | ESCC | 1.99e-10 | 2.26e-01 | 0.1149 |
100128822 | LINC01003 | P30T-E | Human | Esophagus | ESCC | 4.97e-10 | 2.87e-01 | 0.137 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Esophagus | ESCC: Esophageal squamous cell carcinoma | |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Stomach | WIM | |
Stomach | SIM | |
Liver | NAFLD | |
Liver | Cirrhotic | |
Liver | HCC |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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