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Gene: KLF16 |
Gene summary for KLF16 |
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Gene information | Species | Human | Gene symbol | KLF16 | Gene ID | 83855 |
Gene name | Kruppel like factor 16 | |
Gene Alias | BTEB4 | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q9BXK1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83855 | KLF16 | HCC1_Meng | Human | Liver | HCC | 1.34e-08 | 1.26e-02 | 0.0246 |
83855 | KLF16 | HCC2_Meng | Human | Liver | HCC | 1.30e-12 | 1.19e-01 | 0.0107 |
83855 | KLF16 | HCC2 | Human | Liver | HCC | 1.72e-06 | 7.90e-01 | 0.5341 |
83855 | KLF16 | S014 | Human | Liver | HCC | 1.60e-04 | 2.19e-01 | 0.2254 |
83855 | KLF16 | S015 | Human | Liver | HCC | 1.86e-09 | 3.60e-01 | 0.2375 |
83855 | KLF16 | S016 | Human | Liver | HCC | 2.04e-12 | 3.06e-01 | 0.2243 |
83855 | KLF16 | S027 | Human | Liver | HCC | 2.49e-06 | 6.04e-01 | 0.2446 |
83855 | KLF16 | S028 | Human | Liver | HCC | 3.39e-18 | 4.88e-01 | 0.2503 |
83855 | KLF16 | S029 | Human | Liver | HCC | 3.22e-16 | 5.06e-01 | 0.2581 |
83855 | KLF16 | C04 | Human | Oral cavity | OSCC | 1.35e-08 | 5.92e-01 | 0.2633 |
83855 | KLF16 | C21 | Human | Oral cavity | OSCC | 1.57e-05 | 1.56e-01 | 0.2678 |
83855 | KLF16 | C30 | Human | Oral cavity | OSCC | 1.19e-21 | 8.16e-01 | 0.3055 |
83855 | KLF16 | C38 | Human | Oral cavity | OSCC | 1.75e-03 | 4.52e-01 | 0.172 |
83855 | KLF16 | C46 | Human | Oral cavity | OSCC | 4.33e-02 | 8.38e-02 | 0.1673 |
83855 | KLF16 | C51 | Human | Oral cavity | OSCC | 4.18e-06 | 4.55e-01 | 0.2674 |
83855 | KLF16 | C57 | Human | Oral cavity | OSCC | 2.06e-04 | 2.37e-01 | 0.1679 |
83855 | KLF16 | C08 | Human | Oral cavity | OSCC | 5.87e-04 | 1.44e-01 | 0.1919 |
83855 | KLF16 | LN46 | Human | Oral cavity | OSCC | 4.44e-02 | 1.73e-01 | 0.1666 |
83855 | KLF16 | SYSMH1 | Human | Oral cavity | OSCC | 1.99e-06 | 1.99e-01 | 0.1127 |
83855 | KLF16 | SYSMH2 | Human | Oral cavity | OSCC | 1.79e-16 | 3.98e-01 | 0.2326 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Stomach | WIM | ![]() |
Stomach | SIM | ![]() |
Liver | NAFLD | ![]() |
Liver | Cirrhotic | ![]() |
Liver | HCC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
KLF16 | CD8TCM | Endometrium | ADJ | ELOVL6,CCDC77,NCEH1, etc. | 1.74e-01 | ![]() |
KLF16 | TFH | Lung | MIAC | KLRC2,AP005482.1,IFITM1, etc. | 1.67e-01 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KLF16 | SNV | Missense_Mutation | novel | c.326N>T | p.Ser109Phe | p.S109F | Q9BXK1 | protein_coding | deleterious(0.05) | benign(0.007) | TCGA-C5-A7XC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
KLF16 | SNV | Missense_Mutation | rs775035830 | c.748G>A | p.Ala250Thr | p.A250T | Q9BXK1 | protein_coding | deleterious_low_confidence(0) | benign(0.034) | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD |
KLF16 | SNV | Missense_Mutation | c.629N>T | p.Pro210Leu | p.P210L | Q9BXK1 | protein_coding | deleterious(0.01) | probably_damaging(0.914) | TCGA-CK-5912-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
KLF16 | SNV | Missense_Mutation | novel | c.509N>A | p.Arg170His | p.R170H | Q9BXK1 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-A5-A2K3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
KLF16 | SNV | Missense_Mutation | novel | c.533A>G | p.His178Arg | p.H178R | Q9BXK1 | protein_coding | deleterious(0) | possibly_damaging(0.874) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KLF16 | SNV | Missense_Mutation | c.616N>A | p.Ala206Thr | p.A206T | Q9BXK1 | protein_coding | deleterious(0.05) | possibly_damaging(0.832) | TCGA-B5-A11H-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Hormone Therapy | megace | SD | |
KLF16 | SNV | Missense_Mutation | c.719N>T | p.Ala240Val | p.A240V | Q9BXK1 | protein_coding | deleterious(0.02) | benign(0.003) | TCGA-D1-A167-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KLF16 | SNV | Missense_Mutation | novel | c.502N>C | p.Phe168Leu | p.F168L | Q9BXK1 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-EY-A1GT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unspecific | Carboplatin | SD |
KLF16 | SNV | Missense_Mutation | novel | c.442C>A | p.Leu148Met | p.L148M | Q9BXK1 | protein_coding | deleterious(0.05) | benign(0.157) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KLF16 | SNV | Missense_Mutation | novel | c.565N>C | p.Cys189Arg | p.C189R | Q9BXK1 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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