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Gene: KIN |
Gene summary for KIN |
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Gene information | Species | Human | Gene symbol | KIN | Gene ID | 22944 |
Gene name | Kin17 DNA and RNA binding protein | |
Gene Alias | BTCD | |
Cytomap | 10p14 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | O60870 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
22944 | KIN | LZE2T | Human | Esophagus | ESCC | 4.04e-02 | 2.31e-01 | 0.082 |
22944 | KIN | LZE4T | Human | Esophagus | ESCC | 1.69e-11 | 2.67e-01 | 0.0811 |
22944 | KIN | LZE5T | Human | Esophagus | ESCC | 6.85e-03 | 1.45e-01 | 0.0514 |
22944 | KIN | LZE7T | Human | Esophagus | ESCC | 7.41e-05 | 1.54e-01 | 0.0667 |
22944 | KIN | LZE8T | Human | Esophagus | ESCC | 6.47e-07 | 1.45e-01 | 0.067 |
22944 | KIN | LZE22T | Human | Esophagus | ESCC | 2.32e-04 | 3.38e-01 | 0.068 |
22944 | KIN | LZE24T | Human | Esophagus | ESCC | 1.20e-16 | 3.55e-01 | 0.0596 |
22944 | KIN | LZE6T | Human | Esophagus | ESCC | 2.99e-04 | 1.27e-01 | 0.0845 |
22944 | KIN | P1T-E | Human | Esophagus | ESCC | 1.59e-13 | 4.63e-01 | 0.0875 |
22944 | KIN | P2T-E | Human | Esophagus | ESCC | 4.30e-23 | 3.55e-01 | 0.1177 |
22944 | KIN | P4T-E | Human | Esophagus | ESCC | 3.52e-32 | 5.81e-01 | 0.1323 |
22944 | KIN | P5T-E | Human | Esophagus | ESCC | 4.72e-13 | 3.15e-01 | 0.1327 |
22944 | KIN | P8T-E | Human | Esophagus | ESCC | 1.52e-21 | 4.03e-01 | 0.0889 |
22944 | KIN | P9T-E | Human | Esophagus | ESCC | 1.93e-07 | 1.69e-01 | 0.1131 |
22944 | KIN | P10T-E | Human | Esophagus | ESCC | 2.88e-17 | 2.48e-01 | 0.116 |
22944 | KIN | P11T-E | Human | Esophagus | ESCC | 5.29e-08 | 1.74e-01 | 0.1426 |
22944 | KIN | P12T-E | Human | Esophagus | ESCC | 1.11e-40 | 6.70e-01 | 0.1122 |
22944 | KIN | P15T-E | Human | Esophagus | ESCC | 3.79e-17 | 2.99e-01 | 0.1149 |
22944 | KIN | P16T-E | Human | Esophagus | ESCC | 3.31e-22 | 4.43e-01 | 0.1153 |
22944 | KIN | P17T-E | Human | Esophagus | ESCC | 4.53e-08 | 2.81e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Stomach | WIM | ![]() |
Stomach | SIM | ![]() |
Liver | NAFLD | ![]() |
Liver | Cirrhotic | ![]() |
Liver | HCC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00062604 | Esophagus | ESCC | DNA replication | 181/8552 | 260/18723 | 3.55e-15 | 2.05e-13 | 181 |
GO:00063101 | Esophagus | ESCC | DNA recombination | 168/8552 | 305/18723 | 5.58e-04 | 3.05e-03 | 168 |
GO:00062601 | Liver | HCC | DNA replication | 146/7958 | 260/18723 | 5.68e-06 | 7.02e-05 | 146 |
GO:00062603 | Oral cavity | OSCC | DNA replication | 159/7305 | 260/18723 | 3.25e-13 | 1.59e-11 | 159 |
GO:0006310 | Oral cavity | OSCC | DNA recombination | 147/7305 | 305/18723 | 6.33e-04 | 3.56e-03 | 147 |
GO:000626011 | Oral cavity | LP | DNA replication | 97/4623 | 260/18723 | 3.67e-06 | 7.75e-05 | 97 |
GO:00062606 | Thyroid | PTC | DNA replication | 114/5968 | 260/18723 | 3.09e-05 | 2.95e-04 | 114 |
GO:000626013 | Thyroid | ATC | DNA replication | 124/6293 | 260/18723 | 1.58e-06 | 1.93e-05 | 124 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIN | SNV | Missense_Mutation | c.146C>G | p.Ser49Cys | p.S49C | O60870 | protein_coding | deleterious(0) | possibly_damaging(0.707) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
KIN | SNV | Missense_Mutation | c.895N>T | p.His299Tyr | p.H299Y | O60870 | protein_coding | tolerated(1) | benign(0) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR | |
KIN | SNV | Missense_Mutation | novel | c.775T>A | p.Ser259Thr | p.S259T | O60870 | protein_coding | tolerated(0.1) | probably_damaging(0.971) | TCGA-C5-A8YT-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
KIN | insertion | Frame_Shift_Ins | novel | c.874_875insCGCTGAGT | p.Lys292ThrfsTer20 | p.K292Tfs*20 | O60870 | protein_coding | TCGA-DS-A1OA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | ||
KIN | SNV | Missense_Mutation | c.1025N>T | p.Arg342Ile | p.R342I | O60870 | protein_coding | tolerated(0.19) | benign(0.095) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
KIN | SNV | Missense_Mutation | rs543372718 | c.247N>T | p.Arg83Cys | p.R83C | O60870 | protein_coding | tolerated(0.06) | benign(0.024) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
KIN | SNV | Missense_Mutation | novel | c.145N>C | p.Ser49Pro | p.S49P | O60870 | protein_coding | deleterious(0.02) | benign(0.003) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KIN | SNV | Missense_Mutation | c.1025G>T | p.Arg342Ile | p.R342I | O60870 | protein_coding | tolerated(0.19) | benign(0.095) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
KIN | SNV | Missense_Mutation | novel | c.441A>C | p.Glu147Asp | p.E147D | O60870 | protein_coding | tolerated(0.06) | probably_damaging(0.949) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
KIN | deletion | Frame_Shift_Del | c.1095_1096delNN | p.Ala367TyrfsTer5 | p.A367Yfs*5 | O60870 | protein_coding | TCGA-AF-6655-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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