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Gene: HYKK |
Gene summary for HYKK |
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Gene information | Species | Human | Gene symbol | HYKK | Gene ID | 123688 |
Gene name | hydroxylysine kinase | |
Gene Alias | AGPHD1 | |
Cytomap | 15q25.1 | |
Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | A2RU49 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
123688 | HYKK | C21 | Human | Oral cavity | OSCC | 6.76e-03 | 1.88e-01 | 0.2678 |
123688 | HYKK | C43 | Human | Oral cavity | OSCC | 2.19e-04 | 6.62e-02 | 0.1704 |
123688 | HYKK | C46 | Human | Oral cavity | OSCC | 2.39e-04 | 1.59e-01 | 0.1673 |
123688 | HYKK | C08 | Human | Oral cavity | OSCC | 6.04e-04 | 1.08e-01 | 0.1919 |
123688 | HYKK | LP16 | Human | Oral cavity | LP | 8.45e-04 | 5.70e-01 | 0.1055 |
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Tissue | Expression Dynamics | Abbreviation |
Oral Cavity | ![]() | EOLP: Erosive Oral lichen planus |
LP: leukoplakia | ||
NEOLP: Non-erosive oral lichen planus | ||
OSCC: Oral squamous cell carcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Stomach | WIM | ![]() |
Stomach | SIM | ![]() |
Liver | NAFLD | ![]() |
Liver | Cirrhotic | ![]() |
Liver | HCC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00442826 | Oral cavity | OSCC | small molecule catabolic process | 174/7305 | 376/18723 | 2.25e-03 | 1.00e-02 | 174 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HYKK | SNV | Missense_Mutation | rs377660640 | c.154N>A | p.Val52Ile | p.V52I | A2RU49 | protein_coding | tolerated(0.5) | benign(0) | TCGA-VS-A9UL-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD |
HYKK | SNV | Missense_Mutation | c.530A>G | p.Asn177Ser | p.N177S | A2RU49 | protein_coding | tolerated(0.45) | benign(0.124) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HYKK | SNV | Missense_Mutation | novel | c.674N>A | p.Gly225Glu | p.G225E | A2RU49 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HYKK | SNV | Missense_Mutation | c.958G>A | p.Ala320Thr | p.A320T | A2RU49 | protein_coding | deleterious(0) | benign(0.206) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HYKK | SNV | Missense_Mutation | c.772N>C | p.Ser258Arg | p.S258R | A2RU49 | protein_coding | deleterious(0.04) | benign(0.356) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HYKK | SNV | Missense_Mutation | novel | c.555N>T | p.Glu185Asp | p.E185D | A2RU49 | protein_coding | tolerated(0.24) | benign(0.05) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
HYKK | SNV | Missense_Mutation | rs774476762 | c.403N>A | p.Ala135Thr | p.A135T | A2RU49 | protein_coding | deleterious(0.01) | possibly_damaging(0.833) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HYKK | SNV | Missense_Mutation | novel | c.761N>C | p.Phe254Ser | p.F254S | A2RU49 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HYKK | SNV | Missense_Mutation | rs569690132 | c.71C>T | p.Ala24Val | p.A24V | A2RU49 | protein_coding | tolerated(0.09) | benign(0.102) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HYKK | SNV | Missense_Mutation | novel | c.613N>A | p.His205Asn | p.H205N | A2RU49 | protein_coding | tolerated(0.13) | benign(0) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
123688 | HYKK | KINASE | varenicline | VARENICLINE |
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