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Gene: HTR1D |
Gene summary for HTR1D |
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Gene information | Species | Human | Gene symbol | HTR1D | Gene ID | 3352 |
Gene name | 5-hydroxytryptamine receptor 1D | |
Gene Alias | 5-HT1D | |
Cytomap | 1p36.12 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | P28221 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3352 | HTR1D | HCC2 | Human | Liver | HCC | 5.11e-07 | 1.69e+00 | 0.5341 |
3352 | HTR1D | S014 | Human | Liver | HCC | 4.27e-19 | 5.47e-01 | 0.2254 |
3352 | HTR1D | S015 | Human | Liver | HCC | 6.87e-25 | 8.18e-01 | 0.2375 |
3352 | HTR1D | S016 | Human | Liver | HCC | 4.24e-18 | 4.99e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Stomach | WIM | ![]() |
Stomach | SIM | ![]() |
Liver | NAFLD | ![]() |
Liver | Cirrhotic | ![]() |
Liver | HCC | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HTR1D | SNV | Missense_Mutation | c.1053N>G | p.Ile351Met | p.I351M | P28221 | protein_coding | deleterious(0) | possibly_damaging(0.883) | TCGA-A2-A04W-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
HTR1D | SNV | Missense_Mutation | c.809N>G | p.Ser270Cys | p.S270C | P28221 | protein_coding | deleterious(0.01) | probably_damaging(0.94) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
HTR1D | SNV | Missense_Mutation | rs779362864 | c.629N>T | p.Ser210Leu | p.S210L | P28221 | protein_coding | tolerated(1) | benign(0.426) | TCGA-EW-A3E8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | anastrozole | SD |
HTR1D | insertion | Nonsense_Mutation | novel | c.871_872insACATCTCTTTCTCATTAGAGATCTGAAAACTCATTAGAGATG | p.Ile291delinsAsnIleSerPheSerLeuGluIleTerLysLeuIleArgAspVal | p.I291delinsNISFSLEI*KLIRDV | P28221 | protein_coding | TCGA-BH-A0B1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin | SD | ||
HTR1D | SNV | Missense_Mutation | rs779362864 | c.629N>T | p.Ser210Leu | p.S210L | P28221 | protein_coding | tolerated(1) | benign(0.426) | TCGA-DG-A2KM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
HTR1D | SNV | Missense_Mutation | rs761191232 | c.445C>T | p.Arg149Cys | p.R149C | P28221 | protein_coding | deleterious(0.03) | probably_damaging(0.969) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
HTR1D | SNV | Missense_Mutation | rs376034704 | c.800N>T | p.Ser267Leu | p.S267L | P28221 | protein_coding | tolerated(0.28) | benign(0.003) | TCGA-AA-A03F-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
HTR1D | SNV | Missense_Mutation | rs780794417 | c.464N>T | p.Ala155Val | p.A155V | P28221 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HTR1D | SNV | Missense_Mutation | rs41268111 | c.289N>A | p.Ala97Thr | p.A97T | P28221 | protein_coding | tolerated(0.18) | benign(0.15) | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HTR1D | deletion | Frame_Shift_Del | c.518delN | p.Pro173ArgfsTer18 | p.P173Rfs*18 | P28221 | protein_coding | TCGA-AA-3833-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3352 | HTR1D | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | agonist | CHEMBL2062265 | ||
3352 | HTR1D | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | ERGOTAMINE | ERGOTAMINE | ||
3352 | HTR1D | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | agonist | 135651366 | ZOLMITRIPTAN | |
3352 | HTR1D | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | Almogran | |||
3352 | HTR1D | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | agonist | CHEMBL1200601 | NARATRIPTAN HYDROCHLORIDE | |
3352 | HTR1D | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | TGBA01AD | |||
3352 | HTR1D | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | agonist | 178103687 | ALMOTRIPTAN | |
3352 | HTR1D | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | agonist | 135650081 | ||
3352 | HTR1D | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | Dihydroergotamine nasal | |||
3352 | HTR1D | DRUGGABLE GENOME, G PROTEIN COUPLED RECEPTOR | antagonist | 135652727 | YOHIMBINE |
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